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Dana P Tannenbaum

Publications and source records attributed to Dana P Tannenbaum.

2 recordsLinked to original sources
PubMed2004

Identifying early glaucoma with optical coherence tomography.

PURPOSE: To evaluate performance of optical coherence tomography (OCT) for detection of early glaucoma. DESIGN: Observational case-control study. METHODS SETTING: University-based tertiary care center. STUDY POPULATION: One eye from 50 normals, 42 glaucoma suspects, and 59 early glaucoma patients meeting the following criteria: visual field (VF) mean deviation > or =-6.00 dB, age > or =40 years, spherical refractive error < or =5 diopters, astigmatism < or =3 diopters, and visual acuity > or =20/30. OBSERVATION PROCEDURE: Early glaucoma by VF (EGVF) was described as repeatable abnormal achromatic VFs based on predefined criteria. Glaucoma suspects (GS) were defined as presence of glaucomatous disk appearance with normal achromatic VFs. OUTCOME MEASURES: Average nerve fiber layer thickness (NFLT) and NFLT in each of four quadrants and 12 clock-hour sectors. Receiver operating characteristic curves and sensitivity and specificity were used to assess the performance of OCT. RESULTS: Average NFLT was 128.4 +/- 15.4, 102.0 +/- 25.4, and 86.5 +/- 31.5 microm in normal, GS, and EGVF eyes, respectively. Normal eyes were different from both glaucoma groups (P <.001); NFLT in the superior quadrant and at the 11 o'clock position had the highest area under the receiver operating characteristic curve (.840 and.933) in the GS and EGVF groups (P =.03). The sensitivity of the OCT for detection of glaucoma was 71% and 85% for the GS and EGVF groups with specificity fixed at 90%. CONCLUSION: The OCT discriminates well between eyes with early perimetric glaucoma and normal eyes. However, its performance is less adequate in eyes with suspicious disk and normal VFs.

Adult↗
PubMed2004

Variable corneal compensation improves discrimination between normal and glaucomatous eyes with the scanning laser polarimeter.

PURPOSE: The presently available scanning laser polarimeter (SLP) has a fixed corneal compensator (FCC) that neutralizes corneal birefringence only in eyes with birefringence that matches the population mode. A prototype variable corneal compensator (VCC) provides neutralization of individual corneal birefringence based on individual macular retardation patterns. The aim of this study was to evaluate the relative ability of the SLP with the FCC and with the VCC to discriminate between normal and glaucomatous eyes. DESIGN: Prospective, nonrandomized, comparative case series. PARTICIPANTS: Algorithm-generating set consisting of 56 normal eyes and 55 glaucomatous eyes and an independent data set consisting of 83 normal eyes and 56 glaucomatous eyes. TESTING: Sixteen retardation measurements were obtained with the SLP with the FCC and the VCC from all subjects. MAIN OUTCOME MEASURES: Dependency of parameters on age, gender, ethnic origin, and eye side was sought. Logistic regression was used to evaluate how well the various parameters could detect glaucoma. Discriminant functions were generated, and the area under the receiver operating characteristic (ROC) curve was determined. RESULTS: Discrimination between normal and glaucomatous eyes on the basis of single parameters was significantly better with the VCC than with the FCC for 6 retardation parameters: nasal average (P = 0.0003), superior maximum (P = 0.0003), ellipse average (P = 0.002), average thickness (P = 0.003), superior average (P = 0.010), and inferior average (P = 0.010). Discriminant analysis identified the optimal combination of parameters for the FCC and for the VCC. When the discriminant functions were applied to the independent data set, areas under the ROC curve were 0.84 for the FCC and 0.90 for the VCC (P<0.021). When the discriminant functions were applied to a subset of patients with early visual field loss, areas under the ROC curve were 0.82 for the FCC and 0.90 for the VCC (P<0.016). CONCLUSION: Individual correction for corneal birefringence with the VCC significantly improved the ability of the SLP to distinguish between normal and glaucomatous eyes and enabled detection of patients with early glaucoma.

Adult↗