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Daniel Günther

Publications and source records attributed to Daniel Günther.

2 recordsLinked to original sources

Femoral strain changes after total hip arthroplasty--patient-specific finite element analyses 12 years after operation.

Periprosthetic stress-shielding after total hip arthroplasty (THA) is a well-known phenomenon. Many authors have used the finite element (FE) method to show the effects of THA on animal or human femora. In most cases they have performed cadaver experiments. The current project is a FE analysis based on a retrospective computerized tomography (CT) in vivo data set of 11 patients 12 years after THA. In order to control the analysis, a computationally created stem was implanted at the femur model of the not operated contralateral side. In comparison to the not operated side, there was a significant reduction of the strain energy density (SED) values in all regions of interest (ROI) with the greatest effect near the distal tip of the stem. Only zone 1 showed no clear trend which may be due to load application at the greater trochanter causing local strain peaks. The median SED values changed by -31.65% (ROI 1), -25.64% (ROI 2), -30.82% (ROI 3), -12.35% (ROI 4), -40.10% (ROI 5), -30.37% (ROI 6) and -43.38% (ROI 7). As far as we are aware, the current combination of in vivo CT density data with FE strain analyses after THA is based on the largest number of patients and the longest follow-up period. This combination enables analysis and prediction of the influence of implantation upon bone and can be compared with of remodelling theories. The assessment of mechanical strain data during a follow-up trial could be a new approach for analyzing different hip stems in clinical biomechanics.

Adult↗

Validation data for periprosthetic bone remodelling theories.

Periprosthetic adaptive bone remodelling after total hip arthroplasty (THA) has been frequently simulated in computer models, combining bone remodelling theory with finite element analysis. Unfortunately, there still subsist a lack of clinical data, which are necessary for validation of these simulation results. Therefore, the objective of the current project is to collect prospective volumetric bone density data with a clinical computerized tomography study in seven patients after THA. A retrospective study 12 years after implantation in 11 patients was added. A data set of about 100000 bone voxels for each femur was collected. In all prospective cases, the predominant change is seen during the first year. The average density reduction in the horizontal slices was between 50 and 150 Hounsfield units (HU) (approx. 10%; p<0.001) after 2 years. Loss of density is particularly strong distal of the minor trochanter and decreases from proximal to distal. For the 12 years retrospective study, the contralateral femur provided the control. Similar trends comparable to the prospective 2-year follow-up CT density values were seen in most cases with density reductions of up to 400 HU (30%). However, in one of these cases there was no difference between the operated and the control density. As far as we are aware, this is the first collection of fully prospective 3D validation data in vivo for periprosthetic adaptive bone remodelling theories. The data are also unique as they are suitable for direct patient-specific 3D finite element meshing and individual weight-related loading.

Absorptiometry, Photon↗