Biomedical subjects
Publications and source records attributed to Daniel Holmes.
Ir-catalyzed borylation of 2-substituted indoles selectively yields 7-borylated products in good yields. N-Protection, required for previous functionalizations of 2-substituted indoles, is unnecessary.
[reaction: see text] A one-pot protocol for converting 1,3- and 1,4-substituted aryl halides to arylamine boronate esters is described. This is achieved by sequential Ir-catalyzed aromatic borylation at the least hindered C-H bond of the aryl halide and subsequent Pd-catalyzed C-N coupling at the halide position of the crude arylboronic ester.
Dodecaynes 1a-d have been prepared via a convergent strategy that employs Sonogashira couplings as the carbon-carbon bond-forming tool. Due to the steric bulk of the DMTS groups, 1c adopts a nonplanar conformation, the dynamics of which have been probed by VT-NMR. The cobalt-catalyzed isomerization of 1a,b produced the new conjugated phenylenes 2a,b and 3a,b, respectively. [structure: see text]
We report a new mutation, Asn185Asp, in exon 6 of the ferroportin gene (FPN1) in 15 members of three successive generations of a Canadian family of Scandinavian origin with autosomal dominant hemochromatosis. Hyperferritinemia with low transferrin saturation was noted in younger family members, seven of whom were aged 20 years or less at the time of diagnosis. In those individuals first diagnosed with hemochromatosis in later life, marked hyperferritinemia was accompanied by high transferrin saturation. In contrast to the phenotype of high ferritin with low saturation first reported for ferroportin disease, this family demonstrates a phenotype of iron indices that varies with age.
The first cases of hindered rotation around the triple bond in simple diphenylacetylenes were observed, including that in chiral 2,2'-bis(trimethylsilyl)-6,6'-bis(dimethylthexylsilyl)diphenylacetylene.
Cardiovascular disease (CVD) is currently one of the major contributors to the global burden of disease. Combination treatments to promote a maximal reduction of the ratio between total cholesterol and high-density lipoprotein are currently the most effective way of preventing CVD. In this review, we assess the role of plant sterols and statins in CVD prevention. Statins have been used by millions of patients at high to moderate risk of CVD, while plant sterols are potentially available to whole populations in food products. The benefits and risks of each compound, as well as the combination, are discussed.
An efficient one-pot C-H activation/borylation/oxidation protocol for the preparation of phenols is described. This method is particularly attractive for the generation of meta-substituted phenols bearing ortho-/para-directing groups, as such substrates are difficult to access by other phenol syntheses.
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The syntheses of the title compounds were accomplished by cobalt-catalyzed alkyne cyclotrimerizations using two strategies; the properties of the bent phenylene frame reflect the combined effects of benzocyclobutadienofusion of the component [3]phenylene substructures.
Arylboron compounds have intriguing properties and are important building blocks for chemical synthesis. A family of Ir catalysts now enables the direct synthesis of arylboron compounds from aromatic hydrocarbons and boranes under "solventless" conditions. The Ir catalysts are highly selective for C-H activation and do not interfere with subsequent in situ transformations, including Pd-mediated cross-couplings with aryl halides. By virtue of their favorable activities and exceptional selectivities, these Ir catalysts impart the synthetic versatility of arylboron reagents to C-H bonds in aromatic and heteroaromatic hydrocarbons.