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Biomedical subjects

Daniel I Galper

Publications and source records attributed to Daniel I Galper.

7 recordsLinked to original sources
PubMed2006

TREAD: TReatment with Exercise Augmentation for Depression: study rationale and design.

BACKGROUND: Despite recent advancements in the pharmacological treatment of major depressive disorder (MDD), over half of patients who receive treatment with antidepressant medication do not achieve full remission of symptoms. There is evidence that exercise can reduce depressive symptomatology when used as a treatment for MDD. However, no randomized controlled trials have evaluated exercise as an augmentation strategy for patients with carefully diagnosed MDD who remain symptomatic following an adequate acute phase trial of antidepressant therapy. PURPOSE: TReatment with Exercise Augmentation for Depression (TREAD) is an NIMH-funded, randomized, controlled trial designed to assess the relative efficacy of two doses of aerobic exercise to augment selective serotonin reuptake inhibitor (SSRI) treatment of MDD. METHODS: The TREAD study includes 12 weeks of acute phase treatment with a 12-week post-treatment follow-up. In addition to looking at change in depressive symptoms as a primary outcome, it also includes comprehensive assessment of psychosocial function and treatment adherence. RESULTS: This paper reviews the rationale and design of TREAD and illustrates how we address several key issues in contemporary patient-oriented research on MDD: 1) the use of augmentation strategies in the treatment of depressive disorders in general, 2) the use of non-pharmacological strategies in the treatment of depressive disorders, 3) the considerations of designing a well-controlled trial using two active treatment groups, and 4) the implementation of an adherence program for the use of exercise as a treatment strategy. CONCLUSIONS: The TREAD study is uniquely designed to overcome sources of potential bias and threats to internal and external validity that have limited prior research on the mental health effects of exercise. The study is facilitated by the development of a multidisciplinary research team that includes experts in both depression treatment and exercise physiology, as well as other related fields.

Adolescent↗
PubMed2006

Inverse association between physical inactivity and mental health in men and women.

PURPOSE: The Aerobics Center Longitudinal Study (ACLS) provides the opportunity to evaluate associations between measures of physical activity and mental health in a large and well-characterized population of men and women. METHODS: Participants were 5451 men and 1277 women (20-88 yr) who completed a maximal fitness treadmill test and self-report measures of habitual physical activity, depressive symptoms (Center for Epidemiological Studies Scale for Depression; CES-D) and emotional well-being (General Well-Being Schedule; GWB). To evaluate the dose-response gradient of the association, we classified the sample, separately for men and women, into three levels of relative cardiorespiratory (CR) fitness (low, moderate, high) on the maximal treadmill test, and four levels on a physical activity index of weekly walking, jogging, and running. RESULTS: In both men and women, there was a significant inverse graded dose-response relationship between maximal CR fitness and the CES-D score (P < 0.0001), and a significant positive graded dose-response relationship between CR fitness and the GWB score (P < 0.0001). We also observed dose-response associations between the level of physical activity and both CES-D and GWB scores (P < 0.0001) that peaked at 11-19 miles per week. CONCLUSION: Among men and women in the ACLS, relative increases in maximal CR fitness and habitual physical activity are cross-sectionally associated with lower depressive symptomatology and greater emotional well-being. Prospective epidemiological studies and controlled clinical trials are needed to identify the minimal and optimal levels of physical activity and CR fitness associated with various mental health benefits in different segments of the general population.

Adult↗
PubMed2003

Thermal biofeedback and lower extremity blood flow in adults with diabetes: is neuropathy a limiting factor?

Thermal biofeedback may be a useful adjunctive technique for enhancing cutaneous blood flow in patients with lower-extremity vascular complications of diabetes. However, autonomic, sensory, and/or motor neuropathies may impair vasomotion and limit the ability to alter blood flow and achieve significant foot warming with thermal biofeedback. We examined nerve function associated with four common types of diabetic neuropathy (sympathetic-autonomic, vagal-autonomic, sensory, and motor), hypothesizing that both sympathetic-autonomic and sensory neuropathies would limit the acquisition of biofeedback-mediated foot warming. Twenty-four participants with diabetes mellitus (19 with type II and 5 with type I) received a nerve conduction study and neurological evaluation of the upper and lower extremities. Hand temperature, foot temperature, and electrodermal gradient at the toes were monitored across six thermal biofeedback sessions. Participants were able to significantly raise p < .01) foot temperatures across sessions, an average of 2.2 degrees F. Consistent with our hypotheses, 41% of the variance in foot warming was explained by lower-extremity sympathetic-autonomic and sensory nerve function tests. This study demonstrated that a general diabetic population, including patients with mild-to-moderate neuropathy, can increase skin perfusion with thermal biofeedback. As hypothesized, lower-extremity sympathetic-autonomic and sensory neuropathies interfered with foot warming.

Adolescent↗
PubMed2003

Effects of adjunctive Swedish massage and vibration therapy on short-term postoperative outcomes: a randomized, controlled trial.

OBJECTIVE: To examine the effects of adjunctive postoperative massage and vibration therapy on short-term postsurgical pain, negative affect, and physiologic stress reactivity. DESIGN: Prospective, randomized controlled trial. The treatment groups were: (1) usual postoperative care (UC); (2) UC plus massage therapy; or (3) UC plus vibration therapy. SETTING: The University of Virginia Hospital Surgical Units, Gynecology-Oncology Clinic, and General Clinical Research Center. SUBJECTS: One hundred and five (N = 105) women who underwent an abdominal laparotomy for removal of suspected cancerous lesions. INTERVENTIONS: All patients received UC with analgesic medication. Additionally, the massage group received standardized 45-minute sessions of gentle Swedish massage on the 3 consecutive evenings after surgery and the vibration group received 20-minute sessions of inaudible vibration therapy (physiotones) on the 3 consecutive evenings after surgery, as well as additional sessions as desired. OUTCOME MEASURES: Sensory pain, affective pain, anxiety, distress, analgesic use, systolic blood pressure, 24-hour urine free cortisol, number of postoperative complications, and days of hospitalization. RESULTS: On the day of surgery, massage was more effective than UC for affective (p = 0.0244) and sensory pain (p = 0.0428), and better than vibration for affective pain (p = 0.0015). On postoperative day 2, massage was more effective than UC for distress (p = 0.0085), and better than vibration for sensory pain (p = 0.0085). Vibration was also more effective than UC for sensory pain (p = 0.0090) and distress (p = .0090). However, after controlling for multiple comparisons and multiple outcomes, no significant differences were found. CONCLUSIONS: Gentle Swedish massage applied postoperatively may have minor effects on short-term sensory pain, affective pain, and distress among women undergoing an abdominal laparotomy for removal of suspected malignant tissues.

Abdomen↗
PubMedDate not supplied

Conversational assessment of hypnotic ability to promote hypnotic responsiveness.

In this article, hypnotic responsiveness is conceptualized as the byproduct of hypnotic ability, which is largely unalterable, plus hypnotic participation, which is highly subject to manipulation in the therapeutic context. This framework constitutes the basis of a model for the conversational assessment of hypnotic ability and hypnotic participation, as well as the subsequent tailoring of therapeutic interventions based on that assessment. Specific clinical steps for implementing activities implied by the model are explained and then demonstrated by way of a case example.

Adolescent↗
PubMedDate not supplied

Current status of mind-body interventions for vascular complications of diabetes.

Impaired peripheral blood flow causes complications, disabilities, expenses, and deaths among persons with diabetes mellitus. Many individuals suffer from lower-extremity pain, reduced functional status, and impaired quality of life. Current conventional treatments include lifestyle modification, exercise, medication, and surgery. However, these approaches are often impractical or insufficient. Thermal biofeedback, however, alone or in conjunction with other mind-body techniques, improves peripheral circulation, pain, neuropathy, ulcer healing, ambulatory activity, and quality of life. It is noninvasive, inexpensive, and consistent with community-based approaches to diabetes self-management. As an adjunct to the medical management of diabetes, thermal biofeedback may help ameliorate some of the vascular complications.

Biofeedback, Psychology↗