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Daniel K Lee

Publications and source records attributed to Daniel K Lee.

6 recordsLinked to original sources
PubMed2006

Does the interval between prostate biopsy and radical prostatectomy affect the immediate postoperative outcome?

OBJECTIVE: To determine whether the interval between prostate biopsy and radical prostatectomy (RP) affects the immediate postoperative outcome. PATIENTS AND METHODS: The study was a retrospective chart review of 169 patients who had retropubic RP at our institution. Using a series of univariate and multivariate logistic regression analyses, we evaluated whether the interval between biopsy and RP was a significant independent predictor of operative duration, estimated blood loss, transfusion rate, nerve-sparing (yes/no), positive margin rate, length of stay, complications, and urinary continence after RP. RESULTS: The interval from biopsy to RP was 14-378 days; there were no significant differences in operative duration, estimated intraoperative blood loss, nerve-sparing rate, transfusion rate and amount, hospitalization time, positive margin rate, major postoperative complications, and continence in patients with biopsy to RP intervals above and below the median. The biopsy to RP interval was not an independent predictor of outcomes during or after RP. There were no direct or indirect correlations between biopsy to RP interval and any of the postoperative outcomes. CONCLUSION: The interval between prostate biopsy and retropubic RP appears to have no effect on immediate postoperative outcomes. We were unable to determine a specific minimum required interval beyond 2 weeks after prostate biopsy before proceeding with RP.

Aged↗
PubMed2005

p16 Is upregulated in proliferative inflammatory atrophy of the prostate.

BACKGROUND: Proliferative inflammatory atrophy (PIA) of the prostate is a common histological finding that has been postulated to be associated with prostate cancer. We examine PIA lesions for the expression of p16/CDKN2, a cyclin-dependent kinase inhibitor frequently altered in prostate cancer. METHODS: Within tissues from two independent patient populations ("Test Set" and "Validation Set") undergoing radical prostatectomy, PIA lesions were identified and subjected to immunohistochemical staining for p16. Atrophic epithelial cells and regional normal epithelium were scored for the extent of p16 staining. In the Test Set, staining was also performed for the proliferation marker Ki-67. Double label immunofluorescence was employed to co-localize staining for p16 and Ki-67. RESULTS: p16 expression was elevated in PIA in both data sets compared to normal epithelium (mean percent of cells staining positive in PIA = 11.1%-16.2%; mean percent of cells staining positive in normal = 0.6%-1.3%) (P = 0.0001). As expected from prior studies, the mean Ki-67 index was higher in PIA lesions (mean 8.2% staining positive) versus normal epithelium (mean 1.9% staining positive) (P = 0.0001), and the extent of staining for p16 correlated with Ki-67 (r = 0.7, P < 0.0001). However, co-localization immunofluorescent studies did not demonstrate staining for nuclear p16 and Ki-67 in the same cells. CONCLUSIONS: Increased p16 expression accompanies increased cell proliferation in PIA lesions of the prostate. Yet, on the individual cell level, the upregulation of p16 in PIA lesions appears to represent a non-proliferative stress response, possibly to oxidative damage.

Aged↗
PubMedDate not supplied

Carbon dioxide laser and Apligraf for a painful plantar hypertrophic scar.

We report on a patient with a large, painful hypertrophic scar on the plantar aspect of the left foot who was treated with carbon dioxide laser and a skin substitute (Apligraf) and followed up for longer than 1 year. To our knowledge, no other case reports have been published on the use of a skin substitute to gain coverage and resolution after excision of a hypertrophic scar by carbon dioxide laser.

Cicatrix, Hypertrophic↗