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Biomedical subjects

Daniel M Doleys

Publications and source records attributed to Daniel M Doleys.

11 recordsLinked to original sources
PubMed2003

Clinical characteristics of chronic back pain as a function of gender and oral opioid use.

STUDY DESIGN: A cross-sectional analysis of data derived from patients with chronic spinal pain undergoing evaluation at a multidisciplinary pain treatment center was conducted. OBJECTIVE: To determine whether pain severity, psychological status, and physical disability differed as a function of gender and opioid use, and whether the clinical correlates of opioid use differed in women and men with chronic back pain. SUMMARY OF BACKGROUND DATA: Gender differences in the experience of pain have been widely reported. For example, in the general population, several chronic pain conditions are more prevalent among women than among men, and many experimental studies demonstrate lower pain thresholds and tolerances among women. In addition, recent evidence from studies of experimental and acute clinical pain suggests that responses to analgesic medications may differ in women and men. METHODS: The sample consisted of 240 patients (35% women) with low back, upper back, or neck pain undergoing evaluation for treatment at a multidisciplinary pain center. The patients were classified as opioid or nonopioid users on the basis of self-report and medical record review. All the patients completed a battery of clinical assessments, including measures of pain severity, psychological adjustment, self-reported disability, functional tasks, and pain tolerance. Analyses were conducted to examine clinical variables as a function of gender and opioid use. RESULTS: The results indicated that opioid use was associated with greater self-reported disability and poorer function in both women and men. However, the association of opioid use with affective distress differed between women and men. The women using opioids showed lower affective distress, whereas the opioid-using men reported greater affective distress. Opioid use was not associated with pain severity, although the women reported greater pain than men. CONCLUSIONS: These findings indicate that both opioid use and gender are significant predictors of clinical status of patients with chronic spinal pain. More interesting, these two variables interact because opioid use was associated with increased affective distress among the men, but the reverse was true for the women. In addition, the women reported greater pain severity, which is consistent with some previous findings. Potential explanations for these findings are presented, and the practical implications are discussed.

Administration, Oral↗
PubMed2003

Pain tolerance as a predictor of outcome following multidisciplinary treatment for chronic pain: differential effects as a function of sex.

Sex-related differences in the experience of clinical and experimental pain have been widely reported. Females are at elevated risk for developing several chronic pain conditions and women demonstrate greater sensitivity to noxious stimulation in the laboratory. However, relationships between responses to experimental noxious stimuli and the experience of clinical pain have not been well characterized. One previous study of healthy adults indicated that pain threshold and tolerance were associated with clinical pain among women but not men (i.e. females with lower pain threshold and tolerance reported more clinical pain). In the present investigation, relationships between pain tolerance and outcomes of treatment for chronic pain were evaluated in a sex-dependent manner. Ischemic pain tolerance was assessed prior to treatment in 171 chronic pain patients completing a pain management program. Outcomes were measured as changes in pain severity, affect, and pain-related disability. Over the course of treatment, women demonstrated greater improvement in pain-related disability while men showed more reduction in pain. Ischemic pain tolerance was related to outcome in a sex-specific fashion. Women with higher pain tolerances showed greater improvement in pain, more reduction in pain-related interference, and more increases in activity level than women with lower pain tolerances. In contrast, pain tolerance was not associated with positive treatment outcomes among men. These results indicate that experimental pain responses may be most clinically relevant for women, and that sex differences may exist in the determinants of pain-treatment outcomes.

Adult↗
PubMed2003

Psychological aspects of interventional therapy.

This discussion is not, nor could it hope to be, an exhaustive examination of all of the various interventional therapies. Instead, it is intended to highlight the potential contribution of psychosocial factors. These factors may vary to some degree or another depending on the specific procedure, but clearly play a role whenever the desired outcome involves a reduction in subjective pain, alteration in the adaptiveness with which the patient responds to the experience of pain, and quality of life. Many notables, including Dr. Michael Cousins, have echoed the importance of incorporating interventional therapies into an interdisciplinary approach. Yet, there seems to be a preponderance of "block shops". Even when used for diagnostic or prognostic purposes, the impact of psychosocial variables and the potential relevance of a meaningful behavioral or psychologic evaluation cannot be overstated. It is easy to understand how the reader might conclude that immersing oneself in the minutiae of all these variables could lead to a feeling of intellectual paralysis when it comes to evaluating the data and arriving at a conclusion or diagnosis. However, ignoring these psychosocial variables and their complex interaction does not constitute a solution. This is particularly true in considering discography where, depending on the criteria applied, the percent of "false positives" can vary from 0% to as much as 40%. The implication for the performing of "unnecessary" spine surgery is obvious. The thoughtful practitioner will be mindful of the role of psychosocial variables in so far as they are thought to be relevant in a particular case. The overall contribution of psychosocial variables to the application of interventional therapies for the diagnosis and treatment of pain can be overlooked and ignored, but not denied. A certain percentage of patients will respond in a predictable, desirable or positive fashion purely on a statistical basis. Historically, and there seems to be no reason to believe this will change in the immediate future, the degree to which the psychosocial variables are considered is left up to the interventionalist. Some are content to perform a directed procedure or therapy concerned only, and sometimes to a less than sufficient degree, with the technical adequacy of the procedure. Others will appreciate the role of human factors including those of the practitioner and patient alike, and strive not only for a statistically derived outcome but the best possible outcome for a given patient. Psychosocial factors can sometimes take on the character of "nuisance variables". However, it is hard not to wonder how much care each would want to have given to these factors if one were on the other end of the needle.

Disease Management↗
PubMed2003

Psychologic evaluation for patients undergoing neuroaugmentative procedures.

Neuroaugmentative and neuromodulation therapy continues to expand. New applications are being found for existing technology, such as the use of SCS therapy in the treatment of head pain. The potential impact of existing therapies is enhanced by new discoveries as exemplified by the availability and demonstrated efficacy of different pharmacologic agents and combinations of agents in intrathecal therapy [39]. Increased attention is being paid to cortical stimulation, including motor cortex stimulation and deep brain stimulation. We must, however, not let our fascination for gadgets betray sound sense. The role of psychosocial factors in the outcome of more "objective" and measurable problems, such as spasticity and tremor versus pain, remains an open area of investigation. Although psychologic issues may not be as prevalent in the amelioration of such problems, they may influence the patient's overall level of satisfaction with the therapy and improvement in quality of life.

Electric Stimulation Therapy↗
PubMed1986

The effect of two sites of high frequency vibration on cutaneous pain threshold.

The purpose of this study was to evaluate the effect of two sites of high frequency vibration on experimentally produced pain thresholds. Subjects were assigned to one of two experimental groups. Vibration was applied proximal to the site of pain threshold measurement in one group and distal to the measurement site in the other group. The cutaneous pain threshold was measured at the ulnar aspect of the wrist in both groups prior to, during, and following 5 min of vibration. Subjects were 30 right-handed, Caucasian males with a negative history of upper extremity dysfunction. A repeated measures analysis of variance (ANOVA) was used to analyze the data. There was a significant interaction between vibration site and time of pain threshold measurement. Post hoc analysis of that interaction indicated that a significant difference between experimental groups occurred only during vibration; the distal group values were significantly higher than the proximal group values (P less than 0.03). For the distal group, pain threshold values were significantly higher during vibration than pre vibration and post vibration (P less than 0.05). In the proximal group, there was no significant difference in pain threshold values across the 3 time periods. The results of this study indicate that vibration applied distal to the site of pain can provide temporary analgesia.

Adolescent↗
PubMed1986

Exercise quotas, anticipatory concern and self-efficacy expectancies in chronic pain: a preliminary report.

Reduced activity levels are a frequently encountered problem among chronic pain patients which has been shown to be responsive to exercise quota systems. This study extends the knowledge of exercise quota systems by examining their effects on beliefs relevant to exercise avoidance. Results indicate that exercise quota systems produce systematic increases in both exercise levels and expectancies of capability while reducing worry and concern about exercising. These data highlight the importance of avoidance learning in chronic pain and suggest that the effectiveness of exercise quota systems is related to a deconditioning process based on exposure rather than the process of applying reinforcement to quota achievement.

Adult↗
PubMed1986

The role of self-efficacy expectancies in the prediction of pain tolerance.

The association of self-efficacy expectancies with pain tolerance on the cold pressor test was examined during treatment conditions of setting quotas alone and in conjunction with monetary reinforcement and placebos in 64 college volunteers. It was found that quota setting was an effective means of increasing cold pressor pain tolerance. The addition of monetary reinforcement of quota achievement did not enhance performance, while the addition of a placebo decreased the effectiveness of quota setting. Self-efficacy expectancies were significantly correlated with pain tolerance times and were better predictors of tolerance than pain ratings. Self-efficacy expectancies and pain tolerance times at treatment were both found to predict 1 week follow-up performance.

Humans↗
PubMedDate not supplied

Spousal responses are differentially associated with clinical variables in women and men with chronic pain.

OBJECTIVES: Spousal responses have been related to clinical variables in patients with chronic pain. For example, solicitous responses from spouses have been associated with greater levels of pain and disability among patients with chronic pain. However, few investigators have determined whether spousal solicitousness produces different effects in women versus men with chronic pain. The present study examined pain reports, medication use, psychosocial factors, functional measures, and pain tolerance in patients with chronic pain. METHODS: Subjects included 114 female and 213 male chronic pain patients, who described their spouses as either high or low in solicitousness on the Multidimensional Pain Inventory. Measures of pain severity, affective distress, physical function, medication use, and pain tolerance were examined in women and men with high versus low scores on spousal solicitousness. RESULTS: Among males only, high spousal solicitousness was associated with greater numerical ratings of pain and greater self-reported disability compared with patients with low solicitous spouses. Among females only, the high spousal solicitousness patients showed lower pain tolerance, greater pain-related interference, poorer performance on functional tasks (eg, timed walking, lifting, and carrying tasks), and greater use of opioid medications. In both women and men, spousal solicitousness was associated with higher scores on the MPI pain severity scale. DISCUSSION: These results extend previous findings demonstrating a relationship between spousal responses and patients' adjustment to pain; however, the pattern of these effects appears to be moderated by the sex of the patient. Implications for assessment and treatment of chronic pain are discussed.

Adult↗