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Biomedical subjects

Daniel Malicier

Publications and source records attributed to Daniel Malicier.

5 recordsLinked to original sources

Fatal mephenesin intoxication.

This report describes a death related to the abuse of and intoxication by mephenesin. To the best of our knowledge, this is the first report case of lethal intoxication involving solely mephenesin and reporting mephenesin blood concentrations. The victim was a 48-year-old woman found unconscious at home. Resuscitation was unsuccessful. Toxicological analysis was performed on a blood sample collected during resuscitation. The results being negative, the body was exhumed for an autopsy, which revealed bronchial inhalation syndrome. Analysis in a second laboratory has revealed the presence of mephenesin in samples collected during autopsy. No other drug/toxin was found, and alcohol was negative. Reanalysis of the peripheral blood collected during resuscitation found a mephenesin concentration of 15.81 microg/mL (15-fold greater that the maximum concentration that would result from a single intake of a 500 mg formulation). The pathologist has concluded on a bronchial inhalation syndrome consecutive to a mephenesin overdose as the cause of death. The manner of this death is discussed in the light of the toxicological hair analysis and the medical past of the victim.

Bronchial Diseases↗

[Compensation for medical accidents resulting from the delivery of health care].

The law of March 4, 2002 created procedure of a friendly, contradictory compensation and rapid in supplement of the already existing procedures. This device financed primarily by the social security allows the integral repair of the no faulty medical accidents that the medical act was carried out at the hospital or within a liberal framework of care. However, certain conditions are required so that the request is admissible: the realization of the medical act must be posterior to the 4/9/2001 and the undergone damage must be serious. This friendly procedure also allows the integral repair of the damage by the insurer of the third after opinion of the CRCI (Commission régionale de conciliation et d'indemnisation des accidents médicaux) which recognized the faulty character of the undergone damage.

Accidents↗

[Medicolegal responsibility].

It was from 1835 onwards that jurisprudence considered that the doctor was responsible for his acts and that he must answer to what he does. Yet it took the Mercier act of 20/5/1936 that specified that between the doctor and his client exists a true contract comprising, for the doctor, an undertaking if not obviously to cure the patient, then at least to not give non-specific care but conscientious and attentive care and, except in exceptional circumstances, to conform to the body of evidence of science. This contract is based on a relationship of confidence, and even an involuntary violation of this contractual obligation is sanctioned. A victim of a medical accident has recourse to several types of legal processes, be it a request for civil or administrative indemnity reparations (depending on the whether the damages were incurred in the private sector or in a hospital), or a criminal pursuit if the first objective is to punish the doctor. Two important laws have brought innovations with regards to medical accidents. The law of the 10th of July 2000 has allowed a de-penalisation, whereas the law of 4/3/2002 has allowed more equitable compensation of the therapeutic risk, thus preserving free choice for the victim to seek medical help in the private or the public sector.

France↗

[Death certificate and diagnosis of violent death].

Many crimes go by unpunished, be it due to the disappearance of the cadaver, or a skillful cover-up on the part of the perpetrator. Thus, the crime can be masked as an accident, a suicide, or even a natural death. In France, the writing of the death certificate confers to the doctor, an important role in their unravelling. This role rests solely on a systematic approach consisting of alerting all violent deaths, sudden deaths and suspicious deaths to the coroner's office. The coroner decides whether to hold a medico-legal autopsy according to the various facts carried to his attention.

Autopsy↗