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Biomedical subjects

Daniel Wartenberg

Publications and source records attributed to Daniel Wartenberg.

13 recordsLinked to original sources
PubMed2006

Current practices in spatial analysis of cancer data: mapping health statistics to inform policymakers and the public.

BACKGROUND: To communicate population-based cancer statistics, cancer researchers have a long tradition of presenting data in a spatial representation, or map. Historically, health data were presented in printed atlases in which the map producer selected the content and format. The availability of geographic information systems (GIS) with comprehensive mapping and spatial analysis capability for desktop and Internet mapping has greatly expanded the number of producers and consumers of health maps, including policymakers and the public.Because health maps, particularly ones that show elevated cancer rates, historically have raised public concerns, it is essential that these maps be designed to be accurate, clear, and interpretable for the broad range of users who may view them. This article focuses on designing maps to communicate effectively. It is based on years of research into the use of health maps for communicating among public health researchers. RESULTS: The basics for designing maps that communicate effectively are similar to the basics for any mode of communication. Tasks include deciding on the purpose, knowing the audience and its characteristics, choosing a media suitable for both the purpose and the audience, and finally testing the map design to ensure that it suits the purpose with the intended audience, and communicates accurately and effectively. Special considerations for health maps include ensuring confidentiality and reflecting the uncertainty of small area statistics. Statistical maps need to be based on sound practices and principles developed by the statistical and cartographic communities. CONCLUSION: The biggest challenge is to ensure that maps of health statistics inform without misinforming. Advances in the sciences of cartography, statistics, and visualization of spatial data are constantly expanding the toolkit available to mapmakers to meet this challenge. Asking potential users to answer questions or to talk about what they see is still the best way to evaluate the effectiveness of a specific map design.

Data Interpretation, Statistical↗
PubMed2006

A retrospective occupational cohort study of end-stage renal disease in aircraft workers exposed to trichloroethylene and other hydrocarbons.

OBJECTIVE: Case-control studies suggest hydrocarbons increase end-stage renal disease (ESRD) risk. No cohort studies have been conducted. METHODS: An occupational database was matched to the U.S. Renal Data System, and the outcome of all-cause ESRD was examined using multivariable Cox regression. Sixteen individual hydrocarbons were studied, although exposures were not mutually exclusive. RESULTS: For the 1973-2000 period, there was an approximate twofold increased risk of ESRD among workers exposed to trichloroethylene, 1,1,1-trichloroethane, and JP4 gasoline compared with unexposed subjects (all P < 0.05). Relative risk was greater than unity (P > 0.05) for several other hydrocarbons. Associations attenuated (all P > 0.05) when 2001-2002 data were included in the analyses. CONCLUSIONS: Certain hydrocarbons may increase all-cause ESRD risk. Uncertainty regarding the mechanism for increased risk and the observed attenuation in risk in 2001-2002, as well as the overlap of exposures, complicates interpretation. Additional research is needed.

Aircraft↗
PubMed2006

Military deployment to the Gulf War as a risk factor for psychiatric illness among US troops.

BACKGROUND: Several studies document an excess of psychiatric symptoms among veterans of the the 1991 Gulf War. However, little is known about the prevalence of psychiatric disorders in those who were deployed to that conflict. AIMS: To compare the 12-month prevalence and associated risk factors for DSM Axis I psychiatric diagnoses between random samples of Gulf War-deployed veterans and veterans of the same era not deployed to the Persian Gulf (era veterans). METHOD: Interview data from 967 Gulf War veterans and 784 era veterans were examined to determine current health status, medical conditions, symptoms and Axis I psychiatric disorders. Logistic regression models evaluated risk factors for psychiatric disorder. RESULTS: Gulf War veterans had a significantly higher prevalence of psychiatric diagnoses, with twice the prevalence of anxiety disorders and depression. Lower rank, female gender and divorced or single marital status were significant independent predictors of psychiatric disorder. CONCLUSIONS: Deployment to the Gulf War is associated with a range of mental health outcomes more than 10 years after deployment.

Adult↗
PubMed2005

Chlorpyrifos accumulation patterns for child-accessible surfaces and objects and urinary metabolite excretion by children for 2 weeks after crack-and-crevice application.

The Children's Post-Pesticide Application Exposure Study (CPPAES) was conducted to look at the distribution of chlorpyrifos within a home environment for 2 weeks after a routine professional crack-and-crevice application and to determine the amount of the chlorpyrifos that is absorbed by a child living within the home. Ten residential homes with a 2- to 5-year-old child in each were selected for study, and the homes were treated with chlorpyrifos. Pesticide measurements were made from the indoor air, indoor surfaces, and plush toys. In addition, periodic morning urine samples were collected from each of the children throughout the 2-week period. We analyzed the urine samples for 3,5,6-trichloropyridinol, the primary urinary metabolite of chlorpyrifos, and used the results to estimate the children's absorbed dose. Average chlorpyrifos levels in the indoor air and surfaces were 26 (pretreatment)/120 (posttreatment) ng/m3 and 0.48 (pretreatment)/2.8 (posttreatment) ng/cm2, respectively, reaching peak levels between days 0 and 2; subsequently, concentrations decreased throughout the 2-week period. Chlorpyrifos in/on the plush toys ranged from 7.3 to 1,949 ng/toy postapplication, with concentrations increasing throughout the 2-week period, demonstrating a cumulative adsorption/absorption process indoors. The daily amount of chlorpyrifos estimated to be absorbed by the CPPAES children postapplication ranged from 0.04 to 4.8 microg/kg/day. During the 2 weeks after the crack-and-crevice application, there was no significant increase in the amount of chlorpyrifos absorbed by the CPPAES children.

Air Pollution, Indoor↗
PubMed2004

Spatial epidemiology: current approaches and future challenges.

Spatial epidemiology is the description and analysis of geographic variations in disease with respect to demographic, environmental, behavioral, socioeconomic, genetic, and infectious risk factors. We focus on small-area analyses, encompassing disease mapping, geographic correlation studies, disease clusters, and clustering. Advances in geographic information systems, statistical methodology, and availability of high-resolution, geographically referenced health and environmental quality data have created unprecedented new opportunities to investigate environmental and other factors in explaining local geographic variations in disease. They also present new challenges. Problems include the large random component that may predominate disease rates across small areas. Though this can be dealt with appropriately using Bayesian statistics to provide smooth estimates of disease risks, sensitivity to detect areas at high risk is limited when expected numbers of cases are small. Potential biases and confounding, particularly due to socioeconomic factors, and a detailed understanding of data quality are important. Data errors can result in large apparent disease excess in a locality. Disease cluster reports often arise nonsystematically because of media, physician, or public concern. One ready means of investigating such concerns is the replication of analyses in different areas based on routine data, as is done in the United Kingdom through the Small Area Health Statistics Unit (and increasingly in other European countries, e.g., through the European Health and Environment Information System collaboration). In the future, developments in exposure modeling and mapping, enhanced study designs, and new methods of surveillance of large health databases promise to improve our ability to understand the complex relationships of environment to health.

Bayes Theorem↗
PubMed2003

Physician cesarean delivery rates and risk-adjusted perinatal outcomes.

OBJECTIVE: To compare perinatal outcomes in obstetric practices with high and low cesarean delivery rates. METHODS: We conducted a population-based study based on 171295 singleton births in New Jersey in 1996 and 1997. Vital certificate data for each birth were linked to the corresponding hospital discharge records. Nonsubspecialist obstetricians were divided into three groups based on their cesarean delivery rates during the study period: low (less than 18%), medium (18-27%), and high (greater than 27%). Perinatal mortality, rates of birth injury, and uterine rupture were compared among the physician groups after adjustment for differences in patient risks. RESULTS: Physicians in the frequent cesarean delivery group performed more cesarean deliveries for all major indications. Perinatal mortality rates were comparable among the three physician groups. Low and very low birth weight infants delivered by the high-rate physicians did not have a lower risk of mortality. The risk of intracranial hemorrhage was significantly higher for infants delivered by low-rate physicians than for those delivered by medium-rate physicians (adjusted relative risk [RR] 1.53; 95% confidence interval [CI] 1.07, 2.19). Relative to deliveries by medium-rate physicians, deliveries by low-rate physicians were associated with a lower overall risk of uterine rupture (adjusted RR 0.56; 95% CI 0.34, 0.92). Medium- and high-rate groups had similar occurrences of birth injury and uterine rupture. CONCLUSION: Low cesarean delivery rates reduced the rate of uterine rupture and were not associated with increased perinatal mortality. The data suggest a small increase in intracranial hemorrhages in infants delivered by physicians who perform relatively few cesarean deliveries.

Adolescent↗
PubMed2003

Reported exposures, stressors, and life events among Gulf War Registry veterans.

We investigated the association of 15 exposures, 10 stressors, and 18 life events with illness symptoms reported by 978 veterans who believe they suffer from Gulf War-related illnesses. A mail survey was completed by veterans (60% response rate) from the Gulf War Health Registry. Variables most associated with high symptom group membership were reported chemical/biologic warfare (CBW), concerns with infection and faulty equipment, feelings of mistrust in the military, and disability leading to work stoppage within 2 years after the war. These data suggest that belief in CBW exposure, and the experience of war stress and serious negative life events after the war, are important concomitants of Gulf War illness. Models seeking to explain Gulf War symptoms need to incorporate a range of exposure and psychosocial factors to fully account for important influences.

Adult↗
PubMed2003

Symptom patterns among Gulf War registry veterans.

OBJECTIVES: We identify symptom patterns among veterans who believe they suffer from Gulf War-related illnesses and characterize groups of individuals with similar patterns. METHODS: A mail survey was completed by 1161 veterans drawn from the Gulf War Health Registry. RESULTS: An exploratory factor analysis revealed 4 symptom factors. A K-means cluster analysis revealed 2 groups: (1) veterans reporting good health and few moderate/severe symptoms, and (2) veterans reporting fair/poor health and endorsing an average of 37 symptoms, 75% as moderate/severe. Those in Cluster 2 were more likely to report having 1 or more of 24 medical conditions. CONCLUSIONS: These findings are consistent with previous investigations of symptom patterns in Gulf War veterans. This multisymptom illness may be more fully characterized by the extent, breadth, and severity of symptoms reported.

Chronic Disease↗
PubMedDate not supplied

Latent health effects in firefighters.

Firefighter mortality studies that used standardized mortality ratio (SMR) as a summary measure are reviewed and an overview of time-dependent mortality effects for all causes, CAD, cancer, and respiratory deaths is provided. Of 17 studies reporting SMRs for firefighters, three overlapped with larger studies and six did not contain time-dependent data, leaving eight for inclusion. The time effects showed no increased mortality with increasing time employed and time since first employment (latency) for all-cause mortality or any specific cause. There were many causes of death for which firefighters' SMRs were below one through all durations of employment and latency. There was no convincing evidence that employment as a firefighter is associated with increased all-cause, CAD, cancer, or respiratory disease mortality.

Coronary Artery Disease↗