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Darius R Mehregan

Publications and source records attributed to Darius R Mehregan.

5 recordsLinked to original sources
PubMed2003

Epidermal basaloid proliferation in cutaneous myxomas.

BACKGROUND: Basaloid epidermal proliferations, which histologically resemble basal cell carcinoma, have been described overlying dermatofibromas. Several etiologies have been proposed. Cutaneous myxomas are also benign mesynchymal tumors. PURPOSE: Basaloid proliferations have been noted overlying cutaneous myxomas. We have undertaken a study to attempt to differentiate whether these are basal cell carcinomas or benign basaloid proliferations. METHODS: Thirty cases of cutaneous myxomas were included in this study. The lesions were stained with hematoxylin-eosin and alcian blue. Immunohistochemical staining for both epidermal growth factor receptor (EGF-r) and p53 protein was performed on the cutaneous myxomas with epidermal basaloid proliferation. RESULTS: Of the 30 cases of cutaneous myxomas, nine were found to have an associated overlying basaloid proliferation. The basaloid proliferations were limited to the epidermis overlying the myxoid changes within the dermis. Mitotic figures were rare. Staining for p53 protein showed scattered positive staining in the basal cells in both the basaloid proliferations and adjacent epidermis. EGF-r showed positive staining of the overlying epidermis and basaloid proliferation in five cases. CONCLUSIONS: We report basaloid proliferations overlying cutaneous myxomas and propose that these represent benign adnexal proliferations rather than superficial basal cell carcinoma and are analogous to the basaloid proliferations overlying dermatofibromas.

Adult↗
PubMed2003

Large cell acanthoma.

The large cell acanthoma presents as a slightly scaly tan macule on photodamaged skin. Clinically, it may be difficult to differentiate from a lentigo senilis, pigmented actinic keratosis, or a flat and pigmented seborrheic keratosis. We have studied 19 cases of large cell acanthoma. Large cell acanthomas were identified histologically as having epidermal keratinocytes with nuclei roughly twice the size of adjacent epidermal or adnexal keratinocytes, and as having minimal nuclear pleomorphism. Histologic findings were compared with actinic keratosis and lentigo senilis. Melanocyte density and cellular proliferation were compared using HMB-45 staining of melanocytes and proliferating cell nuclear antigen (PCNA) staining of epidermal keratinocytes. Lentigo senilis and large cell acanthoma both showed increased numbers of melanocytes, as identified by HMB-45 staining. Actinic keratosis shows a statistically increased proliferation rate, as identified by PCNA staining. On the basis of clinical, histologic, and immunohistochemical staining similarities, we believe that large cell acanthoma should be considered as a reaction pattern, possibly related to lentigo senilis.

Biopsy, Needle↗
PubMed2003

Wells' syndrome: a clinical and histopathologic review of seven cases.

Wells' syndrome, or eosinophilic cellulitis, is characterized clinically by an acute dermatitis resembling cellulitis, which evolves into violaceous plaques that resolve spontaneously without scarring. The histopathologic features are dynamic, starting with dermal edema and infiltration of eosinophils, the development of "flame figures," and finishing with the appearance of phagocytic histiocytes. We present the clinical and histopathologic features of seven cases of eosinophilic cellulitis.

Adult↗
PubMed2003

Familial anetoderma.

A 31-year-old Caucasian male presented with a history of erythematous, saccular outpouchings of the skin on his back, shoulders, and upper extremities (Fig. 1). The patient reported that his mother and aunt had a similar skin disorder, which initially began with inflammation, but healed leaving lax skin in its wake. He did not recall the name of the skin condition. Physical examination revealed large confluent zones of sac-like protrusions of erythematous skin on the back and shoulders. Histopathologic examination of the excisional biopsy revealed a relatively unremarkable epidermis. Perivascular lymphocytes were present in small numbers in the papillary dermis. Adnexal structures and deep dermis remained intact. The acid-orcein-Giemsa stain highlighted the absence of elastic fibers within the mid and lower reticular dermis (Fig. 2a,b), consistent with anetoderma.

Adult↗