Biomedical subjects

Darwish H Badran

Publications and source records attributed to Darwish H Badran.

3 recordsLinked to original sources

PubMed2006

Topical phenytoin ointment increases autograft acceptance in rats.

OBJECTIVE: To examine the effectiveness of topical phenytoin in preserving the skin viability and increasing acceptance rate of autograft. METHODS: We conducted this study in the Central Laboratory Animal House of Jordan University of Science and Technology, Irbid, Jordan during the period from September 2004 to June 2005. Forty-two rats were divided into 2 equal groups; full thickness dorsal skin wound (4 cm2) was created in the rats. Twenty-one rats were treated with phenytoin (10% w/w ointment), the other 21 (control) were treated with standard dressing and Vaseline. An autograft was performed one week after treatment. Rats were examined for the presence of healthy granulation tissue, reduction in wound surface dimensions, and time for complete graft attachment. RESULTS: Phenytoin ointment had significantly increased wound bed viability and the rate of graft acceptance (p-value <0.0001). Twenty rats had successful grafting (10% phenytoin); while only 3 rats out of the 21 control had successful grafts. The mean time to complete graft attachment and hair growth in the grafted skin was 6.6 +/- 0.5 days. The mean wound contraction measurements (taken just before grafting) were as follow: control group 59.2 +/- 11.6%, and phenytoin group 55.7 +/- 9.2, difference in skin contractility was not statistically significant. Skin viability was evident by increased vascularity and granular tissue formation at the edges of the wound. CONCLUSION: Phenytoin appears to be an effective method for enhancing the take of the full-thickness skin graft. Further clinical use and evaluation of topical phenytoin ointment in skin grafting are merited.

Animals↗

PubMed2003

Magnetic resonance imaging of normal lumbar intervertebral foraminal height.

OBJECTIVE: To study the pattern and changes of lumbar intervertebral foraminal heights in an asymptomatic Jordanian sample relative to age, sex, level, and correlate values with midpoint vertebral and disc heights. METHODS: One hundred and fifty-three patients (87 male and 66 female) were selected during the study period. The study was carried out at the Jordan University Hospital, Amman, Jordan from June 1999 to June 2000. Parasagittal magnetic resonance images were used to measure intervertebral foraminal heights at all lumbar levels. Values were statistically analyzed and the significance of differences in the means of foraminal heights at different levels in every age group and among age groups was determined. Foraminal height indices and correlation coefficients with midpoint vertebral and disc heights were calculated. RESULTS: The study revealed that the mean foraminal height measured is 20.9 mm 1.7 with a range of 17.1-24 mm. Foraminal heights increased significantly in a craniocaudal pattern reaching a maximum at lumber (L)2/3 in females and at L3/4 in males followed by continuous significant decrease reaching their minimum at L5/sacral (S) 1. In relation to age, foraminal heights decreased significantly in females reaching their minimum in the 7th decade. In males, foraminal heights at L3/4 until L5/S1 increased significantly reaching their maximum in the 5th decade followed by significant decrease reaching their minimum in the 7th decade. Foraminal height indices remained relatively constant. A fair degree of correlation of foraminal heights with intervertebral disc heights and vertebral body heights was evident. CONCLUSION: Foraminal heights show different level and age-dependent characteristic pattern of change between asymptomatic males and females. Changes of foraminal heights seem to directly reflect changes of vertebral body heights. These changes are considered normal age-dependent changes, and are discussed under consideration of adaptation to physical activity and changing hormonal levels.

Adult↗

PubMed2002

The cricothyroid space: a guide for successful thyroidectomy.

OBJECTIVE: The frequent complications of thyroid surgery are mostly related to the anatomy of the region. This stimulated us to look for a starting point that makes exploration of the region easier and consequently reduces complications. We aimed to explore and define the anatomy of the cricothyroid [CT] region from cadaveric dissection and to present the outcome of 73 consecutive thyroidectomies starting from a space in the CT region. METHODS: Dissection in the thyroid gland region and creating a space in the CT region was performed on five cadavers [10 spaces], followed by 73 consecutive thyroidectomies through a standard approach beginning from the CT space. RESULTS: In all cadavers, a space was easily created in the CT region. Vessels, nerves and the parathyroid glands were identified. Standard thyroidectomy starting from the CT space was performed on 73 patients. The external laryngeal nerve was seen in 40% of the cases. The recurrent laryngeal nerve was identified and preserved in all patients. Six patients had temporary hypocalcaemia and eight had a temporary voice change. None of the patients had permanent hypoparathyroidism or recurrent laryngeal nerve palsy. CONCLUSION: The CT space is an avascular space medial to the thyroid lobe and is a good starting point for thyroidectomy that allows easy and safe exploration of the region.

Adult↗