Effects of Perioperative Human Granulocyte Colony-stimulating Factor on Immune Function and Perioperative Infections in Patients Undergoing Abdominal Surgery.
Explore the source record for details and available documents.
Journal Article↗
Biomedical subjects
David A. Bobak
Publications and source records attributed to David A. Bobak.
Gastrointestinal Infections Caused by Cytomegalovirus.
Cytomegalovirus (CMV) is an important human pathogen, causing a variety of syndromes ranging from asymptomatic infections to life-threatening end-organ disease. Infections of the gastrointestinal tract are an especially common form of disease caused by CMV and are usually manifest as luminal infections, such as esophagitis or colitis. Solid organ disease caused by CMV is also known to occur, with hepatitis being the most common syndrome. The large majority of cases of tissue-invasive disease caused by CMV have been reported to occur in immunocompromised hosts. Patients at highest risk for serious CMV-mediated disease are commonly HIV infected, recipients of transplants, or are receiving potent immunosuppressive medications. Intriguingly, several recent reports have discussed the previously underappreciated role of serious forms of CMV-mediated disease occurring in immunocompetent patients. This paper reviews several recent reports addressing important aspects related to the diagnosis, treatment, and management of CMV infections of the gastrointestinal tract.
Journal Article↗
Clinical Trials Report.
Explore the source record for details and available documents.
Journal Article↗
Management and Prevention of Clostridium difficile-Associated Diarrhea.
Clostridium difficile is a major cause of antibiotic-associated diarrhea. While treatment regimens for C. difficile have been available for decades, they remain less than optimal due to the frequent recurrences that occur after therapy is completed. Moreover, the morbidity and expense associated with C. difficile have underscored the need for more effective preventive measures than are currently available. In this review, we outline the current recommendations for treatment and prevention of C. difficile infection and, highlight some promising new approaches that may help to control this common nosocomial pathogen in the future.
Journal Article↗