Biomedical subjects

David Bailey

Publications and source records attributed to David Bailey.

5 recordsLinked to original sources

PubMed2006

Wavelength-dependent selectivity in [4 + 4]-cycloaddition reactions.

Selective excitation of a variety of anthracene derivatives in the presence of anthracene led to the formation of only the cross-cyclomer products, while irradiating these mixtures at wavelengths where anthracene also absorbs led to both dianthracene and the mixed cyclomers being formed. This method was shown to be general, so long as the chromophore was inert toward forming its homodimer and could be irradiated at wavelengths at which anthracene does not absorb.

Journal Article↗

PubMed2005

Complementarity in bimolecular photochromism.

Irradiating 2,3,6,7-tetraphenylanthracene in the presence of 9,10-dimethylanthracene leads to exclusive formation of the cross-dimer. No photochemical reaction is observed when either of these chromophores is irradiated in the absence of the other.

Anthracenes↗

PubMed2003

Paramedic-administered neuromuscular blockade improves prehospital intubation success in severely head-injured patients.

BACKGROUND: The purpose of this study was to evaluate the effect of paramedic-administered neuromuscular blocking agents as part of a rapid-sequence intubation (RSI) protocol on successful intubation of severely head-injured patients in a large, urban prehospital system. METHODS: Adult head-injured patients were prospectively enrolled over 1 year using these inclusion criteria: Glasgow Coma Scale (GCS) score of 3 to 8, transport time > 10 minutes, and inability to intubate without RSI. Midazolam and succinylcholine were administered before laryngoscopy; rocuronium was given after tube placement was confirmed using capnometry, syringe aspiration, and pulse oximetry. The Combitube was used as a salvage airway device. All adult trauma victims with a GCS score of 3 to 8 were identified during the first 12 months of the study as the trial cohort and from the preceding 12 months as the control cohort. The trial and control cohorts were compared with regard to demographic data, mechanism of injury, initial vital signs, and GCS scores. The primary outcome measure was intubation success, defined as insertion of either an endotracheal tube or a Combitube, with patients stratified by GCS score. RESULTS: The trial cohort (n = 249) and control cohort (n = 189) were similar with regard to demographic data, mechanism of injury, and initial vital signs and GCS scores. Intubation success rates increased significantly during the trial period for all patients and when stratified into GCS score of 3 and GCS score of 4 to 8. The percentage of patients intubated without neuromuscular blocking agents actually increased during the trial period. Although the number of intubations by helicopter flight crews decreased during the trial, the overall use of aeromedical resources did not change. CONCLUSION: Paramedic-administered neuromuscular blockade as part of an RSI protocol improves intubation success in a large, urban prehospital system.

Adolescent↗

PubMed2003

ST-segment elevation myocardial infarction, severe anemia and nonobstructive coronary disease: case report and brief comment.

When the metabolic demand of the heart exceeds its oxygen supply, myocardial ischemia or infarction (MI) may occur. One of the causes of this condition is severe anemia. The type of MI associated with cases of supply-demand myocardial mismatch is usually a non-ST elevation infarction (Non-STEMI), and is most commonly seen in patients with underlying coronary artery disease. We present a case report of ST segment elevation MI (STEMI), which we believe was secondary to severe anemia, occurring in the absence of angiographically significant coronary artery stenosis or thrombosis. Coronary artery spasm was not seen. In our review of the literature we found no similar cases (MEDLINE 1966-2002).

Anemia↗

PubMed2002

Paramedic-performed rapid sequence intubation of patients with severe head injuries.

STUDY OBJECTIVE: We evaluate the ability of paramedic rapid sequence intubation (RSI) to facilitate intubation of patients with severe head injuries in an urban out-of-hospital system. METHODS: Adult patients with head injuries were prospectively enrolled over a 1-year period by using the following inclusion criteria: Glasgow Coma Scale score of 3 to 8, transport time of greater than 10 minutes, and inability to intubate without RSI. Midazolam and succinylcholine were administered before laryngoscopy, and rocuronium was given after tube placement was confirmed by means of capnometry, syringe aspiration, and pulse oximetry. The Combitube was used as a salvage airway device. Outcome measures included intubation success rates, preintubation and postintubation oxygen saturation values, arrival arterial blood gas values, and total out-of-hospital times for patients intubated en route versus on scene. RESULTS: Of 114 enrolled patients, 96 (84.2%) underwent successful endotracheal intubation, and 17 (14.9%) underwent Combitube intubation, with only 1 (0.9%) airway failure. There were no unrecognized esophageal intubations. On arrival at the trauma center, median oxygen saturation was 99%, mean arrival PO2 was 307 mm Hg, and mean arrival PCO2 was 35.8 mm Hg. Total out-of-hospital times were higher when RSI was performed on scene (26 versus 13 minutes). CONCLUSION: Paramedics can use RSI protocols that include neuromuscular blocking and sedative agents to facilitate intubation of patients with head injuries.

Adult↗