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David Carpentier

Publications and source records attributed to David Carpentier.

2 recordsLinked to original sources

Random quantum Ising chains with competing interactions.

In this paper we discuss the criticality of a quantum Ising spin chain with competing random ferromagnetic and antiferromagnetic couplings. Quantum fluctuations are introduced via random local transverse fields. First we consider the chain with couplings between first and second neighbors only and then generalize the study to a quantum analog of the Viana-Bray model, defined on a small world random lattice. We use the Dasgupta-Ma decimation technique, both analytically and numerically, and focus on the scaling of the lattice topology, whose determination is necessary to define any infinite disorder transition beyond the chain. In the first case, at the transition the model renormalizes towards the chain, with the infinite disorder fixed point described by Fisher. This corresponds to the irrelevance of the competition induced by the second neighbors couplings. As opposed to this case, this infinite disorder transition is found to be unstable towards the introduction of an arbitrary small density of long range couplings in the small world models.

Journal Article↗

Inducible gene silencing in podocytes: a new tool for studying glomerular function.

Glomerular filtration is one of the primary functions of the kidney. Podocytes, a highly specialized cell type found in glomeruli, are believed to play a critical role in that function. Null mutations of genes expressed in podocytes like WT1, nephrin, and NEPH1 result in an embryo and perinatal lethal phenotype and therefore do not allow the functional analysis of these genes in the adult kidney. Here is describes the generation of a model that will allow such studies. We have engineered transgenic mice in which the disruption of targeted genes can be induced in a temporally controlled fashion in podocytes. For this, a transgene encoding the mutated estrogen receptor-Cre recombinase fusion protein was introduced into the mouse genome. Animals were crossed with Z/AP reporter mice to test for efficient and inducible recombination. We found that, after injection of inducer drug tamoxifen, Cre fusion protein translocates to the nuclei of podocytes, where it becomes active and mediates recombination of DNA carrying loxP target sequences. These animals provide for the first time a tool for silencing genes selectively in podocytes of adult animals.

Animals↗