Biomedical subjects

David Ingle

Publications and source records attributed to David Ingle.

3 recordsLinked to original sources

PubMed2006

Central visual persistences: II. Effects of hand and head rotations.

In an earlier paper, kinesthetic effects on central visual persistences (CPs) were reported, including the ability to move these images by hand following eye closure. While all CPs could be translated anywhere within the frontal field, the present report documents a more selective influence of manual rotations on CPs in the same subjects. When common objects or figures drawn on cards were rotated (while holding one end of the object or one corner of a card between thumb and forefinger), it was found that CPs of larger objects rotated with the hand. By contrast, CPs of smaller objects, parts of objects, and textures remained stable in space as the hand rotated. It is proposed that CPs of smaller stimuli and textures are represented mainly by the ventral stream (temporal cortex) while larger CPs, which rotate, are represented mainly by the dorsal stream (parietal cortex). A second discovery was that CPs of small objects (but not of line segments or textures) could be rotated when the thumb and fingers surrounded the edges of the object. It is proposed that neuronal convergence of visual and tactile information about shape increases parietal responses to small objects, so that their CPs will rotate. Experiments with CPs offer new tools to infer visual coding differences between ventral and dorsal streams in man.

Adult↗

PubMed2006

MRI of knee osteonecrosis in children with leukemia and lymphoma: Part 2, clinical and imaging patterns.

OBJECTIVE: This aim of this study was to explore the relationship between MRI findings and clinical symptoms of knee osteonecrosis in children and to determine the significance of this relationship. Such information is important for early diagnosis of this frequent complication and for choosing an appropriate treatment strategy. MATERIALS AND METHODS: Osteonecrotic lesion size and location were determined in a retrospective analysis of MR images of the knee obtained in our institution during the past 10 years. Association between MRI findings and clinical symptoms expressed by the knee scores was tested for a subgroup of our patient population who had clinical evaluation of the knees in the orthopedic clinic within 6 weeks of their MRI studies. RESULTS: In 80% of patients, osteonecrosis was bilateral. Lesions were distributed as follows: femur and tibia, 66% of the knees; femur alone, 26%; and tibia alone, 8%. Clinical symptoms of knee osteonecrosis were associated with lesions involving the articular surface of the distal femur, large lesions, and involvement of any part of the tibia. MR images showed milder osteonecrosis in patients who were less than 10 years old at the time of primary diagnosis. CONCLUSION: Osteonecrosis affecting the knees of children treated for leukemia and lymphoma is mostly asymptomatic. Children who are 10 years old or older have signs of more advanced osteonecrosis. Clinical symptoms often lag MRI presentation and may develop late in the course of the disease. Routine MRI evaluation is recommended for timely diagnosis of treatment-induced osteonecrosis.

Adolescent↗

PubMed2005

Central visual persistences: I. Visual and kinesthetic interactions.

Phenomena associated with 'central visual persistences' (CPs) are new to both medical and psychological literature. Five subjects have reported similar CPs: positive afterimages following brief fixation of high-contrast objects or drawings and eye closure. CPs duplicate shapes and colors of single objects, lasting for about 15 s. Unlike retinal afterimages, CPs do not move with the eyes but are stable in extrapersonal space during head or body rotations. CPs may reflect sustained neural activity in neurons of association cortex, which mediate object perception. A remarkable finding is that CPs can be moved in any direction by the (unseen) hand holding the original seen object. Moreover, a CP once formed will 'jump' into an extended hand and 'stick' in that hand as it moves about. The apparent size of a CP of a single object is determined by the size of the gap between finger and thumb, even when no object is touched. These CPs can be either magnified or minified via the grip of the extended hand. The felt orientation of the hand-held object will also determine the orientation of the CP seen in that hand. Thus, kinesthetic signals from hand and arm movements can determine perceived location, size, and orientation of CPs. A neural model based on physiological studies of premotor, temporal, parietal, and prefrontal cortices is proposed to account for these novel phenomena.

Adult↗