Safety of aseptically processed allograft tissue.
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Asepsis↗
Biomedical subjects
David J Gocke
Publications and source records attributed to David J Gocke.
Infectious disease risk of cadaveric tissue donors who used non-injected illicit drugs.
This study assessed the correlation between a history of non-injection illicit drug use by cadaveric tissue donors and the presence of markers for Human Immunodeficiency Virus Type 1 (HIV-1), Hepatitis B Virus (HBV), Hepatitis C Virus (HCV), Human T Lymphocyte Virus Types I-II (HTLV-I-II), and Syphilis in their blood. It was found in 12,227 donors recovered in 2000-2002 that 9.68% of individuals with a history of non-injection drug use were seropositive for one or more infectious disease markers compared to 4.26% of donors without a history of drug abuse (p<0.001). A history of non-injection drug use had a positive predictive value of 9.68% and a negative predictive value of 95.74%. Analysis of seropositivity rates associated with individual drugs indicated that 9.6% of cocaine abusers were positive for one or more markers (p<0.001). Other drugs exhibited higher rates of seropositivity but the numbers were insufficient for statistical analysis. Other risk factors (transfusion of blood/blood products, tattoos and body piercing, incarceration) were not associated with higher incidence of infectious disease markers.
Biomarkers↗
Tissue donor selection and safety.
Authors of recent reports in the medical literature indicate that allograft-associated infection primarily is attributable to violations of proper tissue processing procedures, and illustrate the need for effective quality assurance systems to avoid transplantation of potentially infectious tissue. I describe the experience of the members of the Musculoskeletal Transplant Foundation with the selection, the processing, and the safety of bone and tissue donors for allograft implantation. In 2002, the Musculoskeletal Transplant Foundation screened 10,497 potential donors, but only 4431 (42%) met stringent criteria for recovery. After recovery, another 10% of the donors were rejected, usually because of positive infectious disease tests (45%) or an autopsy finding (31%) that rendered the tissues unsuitable for transplantation. Procedures used by the Musculoskeletal Transplant Foundation for ensuring safety of the tissue and for investigating reports of putative infection are described. The Musculoskeletal Transplant Foundation has had no confirmed cases of allograft-associated infection in over 2 million units transplanted during the past 15 years.
Donor Selection↗