Biomedical subjects

David LaBerge

Publications and source records attributed to David LaBerge.

4 recordsLinked to original sources

PubMed2005

Sustained attention and apical dendrite activity in recurrent circuits.

Recurrent neural activity is a pervasive mode of cortical operations and is believed to underlie cognitive functions of working memory, attention, and the generation of spontaneous activity during sleep . It is proposed here that activity in corticothalamic recurrent circuits underlies the sustaining of attention, and that extended durations of attention are made possible by the stabilizing effects of electrical activity in long apical dendrites of pyramidal neurons. Using the cue-target delay task as a framework, the present paper describes sustained attention during the cue-target delay as activity in recurrent circuits involving layer 5/6 pyramidal neurons. At target onset, persistent activity in apical dendrites of layer 2/3 pyramidal neurons (projected from the recurrent circuits) can enhance the processing of incoming pulse trains at basal dendrites. Apical dendrite activity is assumed to modulate the soma processing of layer 2/3 and layer 5/6 pyramidal neurons at subthreshold voltage levels. The variability of successive soma depolarizations from the apical dendrite strongly influences the stability of activity in the corticothalamic recurrent circuit. Lower variability promotes higher stability. According to the present model of apical dendrite function, soma depolarizations can be reduced in variability and maintained within subthreshold levels by increasing the distance that EPSPs propagate along the apical dendrite. The close relationship between sustained attention and the electrical field potentials produced by repeated EPSP propagations in apical dendrites is supported in a brief review of sustained attention experiments that have employed measures of EEG, ERS/ERD, ERP, and LFP.

Animals↗

PubMed2005

Apical dendrite activity in cognition and consciousness.

The ongoing steady nature of consciousness in everyday life implies that the underlying neural activity possesses a high level of stability. The prolonged cognitive events of sustained attention, imagery, and working memory also imply high stability of underlying neural activity. This paper proposes that stabilization of neural activity is produced by apical dendrite activity in pyramidal neurons within recurrent corticothalamic circuits, and proposes that the wave activities of apical dendrites that stabilize ongoing activity constitute the subjective impressions of an attended object and the entire sensory background. The cortical minicolumn, as the functional unit of the cortex, is separated into an axis consisting of layer 5 pyramidal neurons and a surrounding shell consisting of layer 2/3 pyramidal neurons. It is proposed that apical dendrites of the axis generate sensory impressions, and basal dendrites of the shell process the brief-lasting input-output identifications of objects that give rise to ideas.

Attention↗

PubMed2005

Deficit of preparatory attention in children with frontal lobe epilepsy.

We compared the performance of a sustained attention task by children with epilepsy in either the frontal or temporal lobe. In a new simple task that specifically measures preparatory attention, developed recently by LaBerge, Auclair, and Siéroff [LaBerge, D., Auclair, L., & Siéroff, E. (2000). Preparatory attention: Experiment and theory. Consciousness and Cognition, 9, 396-434], patients responded to a target presented in the centre of the display and ignored a distracter presented at locations to the right or the left side of the target. The distracter was presented prior to the onset of the target and the relative frequency of the distracter to target was varied within a block of trials (from 0% to 67%). Children with frontal lobe epilepsy showed a higher mean slope of response time to the target as a function of distracter probability compared to children with temporal lobe epilepsy or compared to the response time slope of control subjects. The response time slope of children with temporal lobe epilepsy did not differ from that of control subjects. These results indicate that the presence of frontal lobe epilepsy selectively affects the capacity of these patients to resist the interference a distracter.

Adolescent↗

PubMed2002

Attentional control: brief and prolonged.

The attention system can be viewed as a collection of modules each of which contains two components: the expression of attention and the controlling operations that produce that expression. Current theories place sites of attentional control in the anterior cortex and sites of expression in the posterior cortex. Attention to a particular location or appearance of an object is itself controlled by instruction from a supervisory system, by the pointing of an arrow cue, and by bottom-up abrupt onsets of stimuli. The control of attention is regulated by cognitive activities such a cognitive load, error monitoring, and current goals. A new development of the triangular circuit theory, together with supporting data, suggest the existence of two modes of activity in columns of attentional expression: brief enhancement of pulse processing that selects information, and prolonged fast oscillations that sustain attention during preparatory and maintenance attention. It is proposed that the direct pathway of the triangular circuit controls the selection of information in the brief attention mode while the indirect pathway through the thalamus controls the production of fast oscillations in the prolonged attention mode.

Attention↗