Biomedical subjects

David M Fergusson

Publications and source records attributed to David M Fergusson.

43 records · Page 3Linked to original sources

PubMed2002

A longitudinal study of the effects of tobacco and cannabis exposure on lung function in young adults.

AIM: To assess the possible effects of tobacco and cannabis smoking on lung function in young adults between the ages of 18 and 26. SETTING AND PARTICIPANTS: A group of over 900 young adults derived from a birth cohort of 1037 subjects born in Dunedin, New Zealand in 1972/73 were studied at age 18, 21 and 26 years. MEASUREMENTS: Cannabis and tobacco smoking were documented at each age using a standardized interview. Lung function, as measured by the forced expiratory volume in one second/vital capacity (FEV1/VC) ratio, was obtained by simple spirometry. A fixed effects regression model was used to analyse the data to take account of confounding factors. FINDINGS: When the sample was stratified for cumulative use, there was evidence of a linear relationship between cannabis use and FEV1/VC (P < 0.05). In the absence of adjusting for other variables, increasing cannabis use over time was associated with a decline in FEV1/VC with time; the mean FEV1/VC among subjects using cannabis on 900 or more occasions was 7.2%, 2.6% and 5.0% less than non-users at ages 18, 21 and 26, respectively. After controlling for potential confounding factors (age, tobacco smoking and weight) the negative effect of cumulative cannabis use on mean FEV1/VC was only marginally significant (P < 0.09). Age (P < 0.001), cigarette smoking (P < 0.05) and weight (P < 0.001) were all significant predictors of FEV1/VC. Cannabis use and daily cigarette smoking acted additively to influence FEV1/VC. CONCLUSIONS: Longitudinal observations over 8 years in young adults revealed a dose-dependent relationship between cumulative cannabis consumption and decline in FEV1/VC. However, when confounders were accounted for the effect was reduced and was only marginally significant, but given the limited time frame over which observations were made, the trend suggests that continued cannabis smoking has the potential to result in clinically important impairment of lung function.

Adult↗

PubMed2002

Deviant partner involvement and offending risk in early adulthood.

BACKGROUND: This paper examines the effects of deviant and non-deviant partner involvement at age 21 on patterns of continuity and change in offending between the ages of 18 and 21 years in a birth cohort of 983 young men and women. RESULTS: Results showed that those involved with a non-deviant partner had lower rates of offending at age 21 than those with no partner, whilst those without a partner had lower rates of offending at age 21 than those involved with a deviant partner. Associations between deviant/non-deviant partner involvement and offending risk best fitted a main effects model in which both offending at age 18 and young people's partnership choices at age 21 made independent and additive contributions to the prediction of offending at age 21. There was no interaction between offending at age 18 and partner choice at age 21 in determining offending risk in early adulthood. In addition, the effects of deviant/non-deviant partner involvement on patterns of offending were the same for men and women, and were found to persist even after extensive control for the confounding effects of a wide range of selection factors measured during childhood and adolescence. CONCLUSION: These results highlight the importance of partnership choices during early adulthood in determining young people's risk of offending as adults.

Adolescent↗

PubMed2002

Maternal use of cannabis and pregnancy outcome.

OBJECTIVE: To document the prevalence of cannabis use in a large sample of British women studied during pregnancy, to determine the association between cannabis use and social and lifestyle factors and assess any independent effects on pregnancy outcome. DESIGN: Self-completed questionnaire on use of cannabis before and during pregnancy. SAMPLE: Over 12,000 women expecting singletons at 18 to 20 weeks of gestation who were enrolled in the Avon Longitudinal Study of Pregnancy and Childhood. METHODS: Any association with the use of cannabis before and during pregnancy with pregnancy outcome was examined, taking into account potentially confounding factors including maternal social background and other substance use during pregnancy. MAIN OUTCOME MEASURES: Late fetal and perinatal death, special care admission of the newborn infant, birthweight, birth length and head circumference. RESULTS: Five percent of mothers reported smoking cannabis before and/or during pregnancy; they were younger, of lower parity, better educated and more likely to use alcohol, cigarettes, coffee, tea and hard drugs. Cannabis use during pregnancy was unrelated to risk of perinatal death or need for special care, but, the babies of women who used cannabis at least once per week before and throughout pregnancy were 216 g lighter than those of non-users, had significantly shorter birth lengths and smaller head circumferences. After adjustment for confounding factors, the association between cannabis use and birthweight failed to be statistically significant (P = 0.056) and was clearly non-linear: the adjusted mean birthweights for babies of women using cannabis at least once per week before and throughout pregnancy were 90 g lighter than the offspring of other women. No significant adjusted effects were seen for birth length and head circumference. CONCLUSIONS: The results of this study suggest that the use of cannabis during pregnancy was not associated with increased risk of perinatal mortality or morbidity in this sample. However, frequent and regular use of cannabis throughout pregnancy may be associated with small but statistically detectable decrements in birthweight.

Adult↗

PubMedDate not supplied

Association between anxiety disorders and substance use disorders among young persons: results of a 21-year longitudinal study.

OBJECTIVE: To examine the linkages between anxiety disorders and the development of substance use disorders in a birth cohort of young people studied to young adulthood. METHOD: Data were gathered over the course of a longitudinal study of a birth cohort of over 1000 New Zealand born young people. Over the course of the study, data were gathered on: (a) anxiety disorders and substance use disorders at ages 16-18 and 18-21; (b) a range of potential confounding factors including measures of childhood, social, and family factors. RESULTS: Young people with anxiety disorders had odds of substance dependence that were between 1.3 and 3.9 times higher than young people without anxiety disorders. These associations were largely explained by a series of covariate factors relating to: (a) childhood and family factors; (b) prior substance dependence; (c) comorbid depression; (d) peer affiliations. After adjustment for these factors, anxiety disorder was unrelated to all measures of substance use. CONCLUSIONS: Young people with anxiety disorders are at increased risk of substance dependence. However, this association appears to be largely or wholly non causal and reflects the associations between childhood factors, prior substance dependence, comorbid depression, peer affiliations and the development of anxiety disorders.

Adolescent↗

PubMedDate not supplied

Mortality and further suicidal behaviour after an index suicide attempt: a 10-year study.

OBJECTIVE: To examine further suicide attempts and mortality in the 10 years after a suicide attempt requiring hospital admission. METHOD: Participants were a consecutive series of 3690 individuals admitted to Christchurch Hospital for attempted suicide during the 10-year period 1993-2002. Data were obtained on admissions to Christchurch Hospital for attempted suicide during the study period. Mortality subsequent to the index suicide attempt was established from the National Mortality Database. The influence of age, gender and method of index suicide attempt on mortality and further suicide attempts requiring hospitalization were examined. RESULTS: Within 10 years, 28.1% of those who had been admitted for an index suicide attempt were readmitted for a further non-fatal suicide attempt, and 4.6% died by suicide. Risks and rates of readmission were higher in: females; those under 55; and those whose index attempt involved a method of low lethality. Risks and rates of suicide were higher in: males; those aged 25 and over; and those using an index suicide attempt method of high lethality. Risks and rates of readmission and mortality from suicide were highest in the first 2 years after the index attempt, although deaths and readmissions occurred throughout the 10 years study period. CONCLUSIONS: Those making suicide attempts requiring hospital admission are at high risk of further hospitalization for suicide attempt and of death from suicide. These findings suggest a need for ongoing support and monitoring, and for enhanced treatment and management of all those making suicide attempts which require hospital admission in an effort to reduce risks of further suicidal behaviour.

Adolescent↗

PubMedDate not supplied

Does father absence place daughters at special risk for early sexual activity and teenage pregnancy?

The impact of father absence on early sexual activity and teenage pregnancy was investigated in longitudinal studies in the United States (N = 242) and New Zealand (N = 520), in which community samples of girls were followed prospectively from early in life (5 years) to approximately age 18. Greater exposure to father absence was strongly associated with elevated risk for early sexual activity and adolescent pregnancy. This elevated risk was either not explained (in the US. study) or only partly explained (in the New Zealand study) by familial, ecological, and personal disadvantages associated with father absence. After controlling for covariates, there was stronger and more consistent evidence of effects of father absence on early sexual activity and teenage pregnancy than on other behavioral or mental health problems or academic achievement. Effects of father absence are discussed in terms of life-course adversity, evolutionary psychology, social learning, and behavior genetic models.

Adolescent↗

PubMedDate not supplied

Panic attacks and the risk of depression among young adults in the community.

OBJECTIVES: To determine the association between panic attacks and the risk of major depression among young adults in the community. METHODS: Data were drawn from a 21-year longitudinal birth cohort study (n = 1, 265). Multiple logistic regression analyses were used to determine the association between panic attacks in adolescence (age 15-21 years) and the risk of current major depression (past month). RESULTS: Having a panic attack in the preceding 3 years was significantly associated with elevated risk of current major depression (past month) at the ages of 18 and 21. This association persisted after adjusting for a range of fixed social, family and individual risk factors for psychopathology, history of major depression, comorbid psychiatric disorder and life adversity among both males (OR = 8.9; 95% CI = 3.9-20.4) and females (OR = 2.3; 95% CI = 1.2-4.2). CONCLUSIONS: These data are consistent with and extend previous work by showing that panic attack increases the risk of current major depression, independent of the effects of psychiatric comorbidity and other early risk factors for psychopathology, though much of this relationship appears to be explained by common risk factors and comorbidity. These data show new evidence of interaction between gender and panic attacks in the risk of depression among young persons. Replication of these findings is needed, as are future studies that further investigate the underlying mechanism of this association.

Adolescent↗