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Biomedical subjects

David M Pober

Publications and source records attributed to David M Pober.

3 recordsLinked to original sources

Development of novel techniques to classify physical activity mode using accelerometers.

PURPOSE: Use of accelerometers to assess physical activity (PA) is widespread in public health research, but their utility is often limited by the accuracy of data-processing techniques. We hypothesized that more sophisticated approaches to data processing could distinguish between activity types based on accelerometer data, providing a more accurate picture of PA. METHODS: Using data from MTI Actigraphs worn by six subjects during four activities (walking, walking uphill, vacuuming, working at a computer), quadratic discriminant analysis (QDA) was performed, and a hidden Markov model (HMM) was trained to recognize the activities. The ability of the new analytic techniques to accurately classify PA was assessed. RESULTS: The mean (SE) percentage of time points for which the QDA correctly identified activity mode was 70.9% (1.2%). Computer work was correctly recognized most frequently (mean (SE) percent correct = 100% (0.01%)), followed by vacuuming (67.5% (1.5%)), uphill walking (58.2% (3.5%)), and walking (53.6% (3.3%)). The mean (SE) percentage of time points for which the HMM correctly identified activity mode was 80.8% (0.9%). Vacuuming was correctly recognized most frequently (mean (SE) percent correct = 98.8% (0.05%)), followed by computer work (97.3% (0.7%)), walking (62.6% (2.3%)), and uphill walking (62.5% (2.3%)). In contrast to a traditional method of data processing that misidentified the intensity level of 100% of the time spent vacuuming and walking uphill, the QDA and HMM approaches correctly estimated the intensity of activity 99% of the time. CONCLUSION: The novel approach of estimating activity mode, rather than activity level, may allow for more accurate field-based estimates of physical activity using accelerometer data, and this approach warrants more study in a larger and more diverse population of subjects and activities.

Acceleration↗

Effects of a single bout of exercise on resting heart rate variability.

PURPOSE: Chronic exercise training has been shown to have a positive influence on cardiac autonomic function as assessed by measures of heart rate variability (HRV). Recent evidence indicates that several benefits associated with exercise training (e.g., improved insulin action, reduced blood pressure, improved blood lipid profile) may be realized transiently after a single bout of exercise. As many of these effects of recent exercise are linked to cardiovascular control systems, the purpose of this investigation was to test the hypothesis that a single bout of exercise would result in favorable changes in cardiac autonomic function as assessed by frequency-domain measures of HRV. METHODS: Subjects were 11 healthy male volunteers ages 18-35 yr. Resting HRV measures were obtained during 5 min of paced breathing before and 1, 3, 6, and 22 h after a 60-min bout of cycling exercise at approximately 65% of peak oxygen uptake. Identical measures were obtained in a nonexercise condition based on a randomized crossover design. RESULTS: Exercise resulted in increased high-frequency HRV, decreased low-frequency HRV, and consequently a decrease in the ratio of low-frequency to high-frequency HRV compared with the nonexercise condition. Additionally, a time-domain measure of HRV (pNN50) was markedly higher in the exercise condition as compared to nonexercise. CONCLUSION: The changes in cardiac autonomic function observed are similar to those seen in investigations of long-term training. These changes indicate a shift in autonomic function toward increased parasympathetic nervous system activity and decreased sympathetic nervous system activity, suggesting a more stable autonomic environment for the heart. These results may provide further evidence of the cardioprotective effects of a single bout of submaximal exercise.

Adolescent↗

Development and validation of a one-mile treadmill walk test to predict peak oxygen uptake in healthy adults ages 40 to 79 years.

The purpose of this investigation was to determine whether the Rockport one-mile walk test equation to predict maximal oxygen uptake was valid for application to treadmill walking. When the Rockport model was found to be inappropriate, a new regression model was developed for predicting peak oxygen uptake (VO2peak) from a one-mile treadmill walk. 304 healthy volunteers ages 40 to 79 years (mean age = 57.6 years, 154 men and 150 women) completed a VO2peak test and a one-mile treadmill walk. Stepwise regression was used to build a model for the relationship between VO2peak and a variety of predictor variables in a sub-sample development group (n = 154). This new model was then applied to a sub-sample validation group (n = 150). The new equation produced a correlation of 0.87, SEE = 4.7 ml x kg (-1) x min (-1) with a mean residual of 0.96 ml x kg (-1) x min (-1). The equation for predicting VO2peak developed in this investigation provides a means of assessing VO2peak that is easy to administer, allows for careful supervision of subjects, and can be completed at a low financial and temporal cost.

Adult↗