Biomedical subjects

David R Stapells

Publications and source records attributed to David R Stapells.

14 recordsLinked to original sources

PubMed2007

Effects of bone oscillator coupling method, placement location, and occlusion on bone-conduction auditory steady-state responses in infants.

OBJECTIVE: The aim of these experiments was to investigate procedures used when estimating bone-conduction thresholds in infants. The objectives were: (i) to investigate the variability in force applied using two common bone-oscillator coupling methods and to determine whether coupling method affects threshold estimation, (ii) to examine effects of bone-oscillator placement on bone-conduction ASSR thresholds, and (iii) to determine whether the occlusion effect is present in infants by comparing bone-conduction ASSR thresholds for unoccluded and occluded ears. DESIGN: Experiment 1A: The variability in the amount of force applied to the bone oscillator by trained assistants (n = 4) for elastic-band and hand-held coupling methods was measured. Experiment 1B: Bone-conduction behavioral thresholds in 10 adults were compared for two coupling methods. Experiment 1C: ASSR thresholds and amplitudes to multiple bone-conduction stimuli were compared in 10 infants (mean age: 17 wk) using two coupling methods. Experiment 2: Bone-conduction ASSR thresholds and amplitudes were compared for temporal, mastoid and forehead oscillator placements in 15 preterm infants (mean age: 35 wk postconceptual age (PCA)). Experiment 3: Bone-conduction ASSR thresholds, amplitudes and phase delays were compared in 13 infants (mean age: 15 wk) for an unoccluded and occluded test ear. All infants that participated had passed a hearing screening test. RESULTS: Experiment 1A: Coupling method did not significantly affect the variability in force applied to the oscillator. Experiment 1B: There were no differences in adult bone-conduction behavioural thresholds between coupling methods. Experiment 1C: There was no significant difference between oscillator coupling method or significant frequency x coupling method interaction for ASSR thresholds or amplitudes in the young infants tested. However, there was a nonsignificant 9-dB better threshold at 4000 Hz for the elastic-band method. Experiment 2: Mean bone-conduction ASSR thresholds for the preterm infants were not significantly different for the temporal and mastoid placements. Mean ASSR thresholds for the forehead placement were significantly higher compared to the other two placements (12-18 dB higher on average). Mean ASSR amplitudes were significantly larger for the temporal and mastoid placements compared to the forehead placement. Experiment 3: There was no difference in mean ASSR thresholds, amplitudes or phase delays for the unoccluded versus occluded conditions. CONCLUSIONS: Trained assistants can apply an appropriate amount of force to the bone oscillator using either the elastic-band or hand-held method. Coupling method has no significant effect on estimation of bone-conduction thresholds; therefore, either may be used clinically provided assistants are appropriately trained. For preterm infants, there are no differences in ASSRs when the oscillator is positioned at the temporal or mastoid placement. However, thresholds are higher and amplitudes are smaller for the forehead placement, consequently, a forehead placement should be avoided for clinical testing. There does not appear to be a significant occlusion effect in young infants; therefore, it may be possible to do bone-conduction testing with ears unoccluded or occluded without applying a correction factor, although further research is needed to confirm this finding.

Acoustic Stimulation↗

PubMed2006

Human electrophysiological examination of buildup of the precedence effect.

Event-related potential correlates of the buildup of precedence effect were examined. Buildup is a type of precedence effect illusion in which perception changes (from hearing two clicks to hearing one click) during a click train. Buildup occurs faster for right-leading than left-leading clicks. Continuous click trains that changed leading sides every 15 clicks were presented. Event-related potential N1 amplitudes became smaller with click train for right-leading only. N1 latency decreased with click trains. Mismatch negativity was seen after lead-lag sides were changed. When the perceived change differed in location (left-to-right), mismatch negativity peaked earlier than when the perceived change differed in location and number of clicks (right-to-left). Results suggest that buildup relates to: N1 refractoriness, event-related potential 'lead domination' and mismatch negativity differences.

Acoustic Stimulation↗

PubMed2006

Multiple auditory steady-state response thresholds to bone-conduction stimuli in young infants with normal hearing.

OBJECTIVE: Multiple auditory steady-state responses (ASSRs) probably will be incorporated into the diagnostic test battery for estimating hearing thresholds in young infants in the near future. Limiting this, however, is the fact that there are no published bone-conduction ASSR threshold data for infants with normal or impaired hearing. The objective of this study was to investigate bone-conduction ASSR thresholds in infants from a Neonatal Intensive Care Unit (NICU) and in young infants with normal hearing and to compare these with adult ASSR thresholds. DESIGN: ASSR thresholds to multiple bone-conduction stimuli (carrier frequencies: 500 to 4000 Hz; 77 to 101-Hz modulation rates; amplitude/frequency modulated; single-polarity stimulus) were obtained in two infant groups [N = 29 preterm (32 to 43 wk PCA), tested in NICU; N = 14 postterm (0 to 8 mo), tested in sound booth]. All infants had passed a hearing screening test. ASSR thresholds, amplitudes, and phase delays for preterm and postterm infants were compared with previously collected adult data. RESULTS: Mean (+/-1 SD) ASSR thresholds were 16 (11), 16 (10), 37 (10), and 33 (13) dB HL for the preterm infants and 14 (13), 2 (7), 26 (6), and 22 (8) dB HL for the postterm infants at 500, 1000, 2000, and 4000 Hz, respectively. Both infant groups had significantly better thresholds for 500 and 1000 Hz compared with 2000 and 4000 Hz, in contrast to adults who have similar thresholds across frequency (22, 26, 18, and 18 dB HL). When 500- and 1000-Hz thresholds were pooled, pre- and postterm infants had better low-frequency thresholds than adults. When 2000- and 4000-Hz thresholds were pooled, pre- and postterm infants had poorer thresholds than adults. ASSR amplitudes were significantly larger for low frequencies compared with high frequencies for both infant groups, in contrast to adults, who show little difference across frequency. ASSR phase delays were later for lower frequencies compared with higher frequencies for infants and adults, except for 500 Hz in the preterm group. ASSR phase delays were later for infants compared with adults across frequency. CONCLUSIONS: Infant bone-conduction ASSR thresholds are very different from those of adults. Overall, these results indicate that low-frequency bone-conduction thresholds worsen and high-frequency bone-conduction thresholds improve with maturation. Bone-conduction ASSR threshold differences between the postterm infants and adults probably are due to skull maturation. Differences between preterm and older infants may be explained both by skull changes and a masking effect of high ambient noise levels in the NICU (and possibly to other issues due to prematurity).

Acoustic Stimulation↗

PubMed2005

Auditory brainstem and middle latency responses to 1 khz tones in noise-masked normally-hearing and sensorineurally hearing-impaired adults.

The present study provides comparative evaluation of the ABR and MLR to 1 kHz brief tones in two groups of hearing-impaired subjects (noise-masked normally-hearing; and sensorineurally hearing-impaired adults), as well as a normally-hearing control group. Tones were presented at intensities from threshold to 80-90 dB nHL. The results of this study show that: (1) the ABR and MLR to these low-frequency (1 kHz) tones are equally accurate in estimating hearing threshold, (2) at supra-threshold levels, there are differences in the ABRs and MLRs for subjects with decreased hearing sensitivity resulting from cochlear pathology, compared to those obtained from adults with simulated hearing loss due to broadband masking, and (3) supra-threshold stimuli produce differential effects on the latency and amplitude characteristics of the ABR and MLR in listeners with true sensorineural hearing impairments. Possible physiologic explanations are offered for this differential pattern of results.

Acoustic Stimulation↗

PubMed2005

Comparison of multiple auditory steady-state responses (80 versus 40 Hz) and slow cortical potentials for threshold estimation in hearing-impaired adults.

This study evaluated the use of multiple auditory steady-state responses (ASSRs) and slow cortical potentials (SCPs) to estimate behavioural audiograms in adults for compensation cases. Two groups of 23 subjects were assessed using either 80 Hz or 40 Hz multiple simultaneous tones with carrier frequencies of 0.5, 1.0, 2.0, and 4.0 kHz. SCP thresholds for 0.5, 1.0, and 2.0 kHz were obtained for both groups. Mean evoked potential thresholds (dB HL) minus behavioural pure-tone thresholds (dB HL) difference scores were 5-17 dB for the 80 Hz group, 1-14 dB for the 40 Hz group, and 20-22 dB for the SCPs. Thresholds for 40 Hz ASSR were significantly closer to behavioural thresholds than were 80 Hz or SCP thresholds. SCP and 40 Hz ASSR audiogram estimates were obtained more quickly than the 80 Hz ASSR. Multiple 40 Hz ASSR is the method of choice for evoked potential threshold estimation in adults.

Acoustic Stimulation↗

PubMed2005

Effects of sensorineural hearing loss and personal hearing AIDS on cortical event-related potential and behavioral measures of speech-sound processing.

OBJECTIVE: To systematically investigate the combined effects of sensorineural hearing loss and prescribed personal hearing aid(s) on cortical event-related potentials (ERPs) (waves N1, MMN, N2b, and P3b) and their related behavioral measures of discrimination (d-prime sensitivity and reaction time) to the speech sounds /ba/ and /da/ presented at 65 and 80 dB peak-to-peak equivalent SPL. DESIGN: Cortical ERPs were recorded to /ba/ and /da/ speech stimuli presented at 65 and 80 dB peak-to-peak equivalent SPL from 20 normal-hearing adults and 14 adults with sensorineural hearing losses. The degree of sensorineural impairment at 1000 to 2000 Hz ranged from moderate losses (50 to 74 dB HL) to severe-profound losses (75 to 120 dB HL). The speech stimuli were presented in an oddball paradigm and cortical ERPs were recorded in both active and passive listening conditions at both stimulus intensities. The adults with hearing impairments were tested in the unaided and aided conditions at each stimulus intensity. Electroacoustic and real-ear testing was performed on each subject's hearing aid(s) before electrophysiology testing to ensure that the hearing aids were functioning at the time of testing. RESULTS: The use of personal hearing aids substantially improved the detectability of all the cortical ERPs and behavioral d-prime performance scores at both stimulus intensities. This was especially true for individuals with severe-profound hearing losses. At 65 dB SPL, mean ERP amplitudes and d-prime sensitivity scores were all significantly higher or better in the aided versus unaided condition. At 80 dB SPL, only the N1 amplitudes and d-prime sensitivity scores were significantly better in the aided condition. Even though the majority of the hearing-impaired subjects showed increased amplitudes, decreased latencies, and better waveform morphology in the aided condition, the amount of response change (improvements) seen in these measures showed considerable variability across subjects. When compared with the responses obtained from the normal-hearing subjects, both hearing-impaired groups had significantly prolonged aided RT latencies at both stimulus intensities and N2b latencies at the higher stimulus intensities. CONCLUSIONS: These results suggest that hearing-impaired individuals' brains process speech stimuli with greater accuracy and in a more effective manner when these individuals use their personal hearing aids. This is especially true at the lower stimulus intensity. The effects of sensorineural hearing loss and personal hearing aids on cortical ERPs and behavioral measures of discrimination are dependent on the degree of sensorineural loss, the intensity of the stimuli, and the level of cortical auditory processing that the response measure is assessing. The possible clinical significance of these cortical ERP and behavioral findings is discussed.

Acoustic Stimulation↗

PubMed2005

Effects of low-pass noise masking on auditory event-related potentials to speech.

OBJECTIVE: This study investigated the effects of decreased audibility in low-frequency spectral regions, produced by low-pass noise masking, on cortical event-related potentials (ERPs) to the speech sounds /ba/ and /da/. DESIGN: The speech sounds were presented to normal-hearing adults (N = 10) at 65- and 80-dB peak-to-peak equivalent SPL while they were engaged in an active condition (pressing a button to deviant sounds) and a passive condition (ignoring the stimuli and reading a book). Broadband masking noise was simultaneously presented at an intensity sufficient to mask the response to the 65-dB speech sounds and subsequently low-pass filtered. The conditions were quiet (no masking), low-pass noise cutoff frequencies of 250, 500, 1000, 2000, and 4000 Hz, and broadband noise. RESULTS: As the cutoff frequency of the low-pass noise masker was raised, ERP latencies increased and amplitudes decreased. The low-pass noise affected N1 differently than the other ERP or behavioral measures, particularly for responses to 80-dB speech stimuli. N1 showed a smaller decrease in amplitude and a smaller increase in latency compared with the other measures. Further, the cutoff frequency where changes first occurred was different for N1. For 80-dB stimuli, N1 amplitudes showed significant changes when the low-pass noise masker cutoff was raised to 4000 Hz. In contrast, d', MMN, N2, and P3 amplitudes did not change significantly until the low-pass noise masker was raised to 2000 Hz. N1 latencies showed significant changes when the low-pass noise masker was raised to 1000 Hz, whereas RT, MMN, N2, and P3 latencies did not change significantly until the low-pass noise masker was raised to 2000 Hz. No significant differences in response amplitudes were seen across the hemispheres (electrode sites C3M versus C4M) in quiet, or in masking noise. CONCLUSIONS: These results indicate that decreased audibility, resulting from the masking, affects N1 in a differential manner compared with MMN, N2, P3, and behavioral measures. N1 indexes the presence of audible stimulus energy, being present when speech sounds are audible, whether or not they are discriminable. MMN indexes stimulus discrimination at a pre-attentive level. It was present only when behavioral measures indicated the ability to differentiate the speech sounds. N2 and P3 also were present only when the speech sounds were behaviorally discriminated. N2 and P3 index stimulus discrimination at a conscious level. These cortical ERP in low-pass noise studies provide insight into the changes in brain processes and behavioral performance that occur when audibility is reduced, such as with low frequency hearing loss.

Adult↗

PubMed2005

Multiple auditory steady-state responses to bone-conduction stimuli in adults with normal hearing.

ASSR thresholds to bone-conduction stimuli were determined in 10 adults with normal hearing using mastoid placement of the bone oscillator. ASSRs to 0-50 dB HL bone-conduction stimuli and to 30-60 dB HL air-conduction stimuli were compared. The effect of alternating stimulus polarity on air- and bone-conduction ASSRs was also investigated. Stimuli were bone- and air-conduction amplitude-modulated tones (500-4000 Hz carrier frequencies, modulated at 77-101 Hz). ASSRs were recorded using the Rotman MASTER research system. Mean (1SD) bone-conduction ASSR thresholds were 22(11), 26(13), 18(8), and 18(11) dB HL for 500, 1000, 2000, and 4000 Hz, respectively. Except for a steeper slope at 500 Hz, ASSR intensity-amplitude functions for binaural bone- and air-conduction stimuli showed the same slopes; intensity-phase-delay functions were steeper at 1000 Hz for ASSRs to bone-conduction stimuli. ASSR amplitudes and phases did not differ for single- versus alternated-stimulus polarities for both bone- and air-conduction stimuli. The steeper amplitude slope for ASSRs to 500 Hz stimuli may reflect a nonauditory contribution to the ASSR.

Adult↗

PubMed2004

Artifactual responses when recording auditory steady-state responses.

OBJECTIVE: The goal of this study was to investigate, in hearing-impaired participants who could not hear the stimuli, the possibility of artifactual auditory steady-state responses (ASSRs) when stimuli are presented at high intensities. DESIGN: ASSRs to single (60 dB HL) and multiple (20 to 50 dB HL; 500 to 4000 Hz) bone-conduction stimuli as well as single 114 to 120 dB HL air-conduction stimuli, were obtained using the Rotman MASTER system, using analog-to-digital (A/D) conversion rates of 500, 1000, and 1250 Hz. Responses (p < 0.05) were considered artifactual when their numbers exceeded that expected by chance. In some conditions, we also obtained ASSRs to "alternated" stimuli (stimuli inverted and ASSRs to the two polarities averaged). A total of 17 subjects were tested. RESULTS: Bone conduction results: 500 Hz A/D rate: Large-amplitude (43 to 1558 nV) artifactual ASSRs were seen at 40 and 50 dB HL for the 500 Hz carrier frequency. Smaller responses (28 to 53 nV) were also recorded at 20 dB HL for the 500 Hz carrier frequency. Artifactual ASSRs (17 to 62 nV) were seen at 40 dB HL and above for the 1000 Hz carrier frequency and at 50 dB HL for the 2000 Hz carrier frequency. Alternating the stimulus polarity decreased the amplitude and occurrence of these artifactual responses but did not eliminate responses for the 500 Hz carrier frequency at 40 dB HL and above. No artifactual responses were recorded for 4000 Hz stimuli for any condition. 1000 Hz A/D rate: Artifactual ASSRs (15 to 523 nV) were seen at 50 dB HL and above for the 500 Hz carrier frequency and 40 dB HL and above for the 1000 Hz carrier frequency. Artifactual responses were also obtained at 50 dB HL for a 2000 Hz carrier frequency but not at lower levels. Artifactual responses were not seen for the 4000 Hz carrier frequency. Alternating the stimulus polarity removed the responses for the 1000 and 2000 Hz carrier frequencies but did not change the results for the 500 Hz carrier frequency. 1250 Hz A/D rate: Artifactual ASSRs (16 to 220 nV) were seen at 50 dB HL and above for the 500 Hz carrier frequency and 60 dB HL and above for the 1000 Hz carrier frequency. Alternating the stimulus polarity removed the responses for the 1000 Hz carrier frequency but did not change the results for the 500 Hz carrier frequency. There were no artifactual responses at 2000 and 4000 Hz. Air conduction results: 500 Hz A/D rate: Artifactual ASSRs (49 to 153 nV) were seen for 114 to 120 dB HL stimuli for 500 and 1000 Hz carrier frequencies. Alternating the stimulus polarity removed these responses. There were no artifactual responses at 2000 and 4000 Hz. 1000 and 1250 Hz A/D rates: Artifactual ASSRs (19 to 55 nV) were seen for a 120 dB HL stimulus for a 1000 Hz carrier. Alternating the stimulus polarity removed these responses. CONCLUSIONS: High-intensity air- or bone-conduction stimuli can produce spurious ASSRs, especially for 500 and 1000 Hz carrier frequencies. High-amplitude stimulus artifact can result in energy that is aliased to exactly the modulation frequency. Choice of signal conditioning (electroencephalogram filter slope and low-pass cutoff) and processing (A/D rate) can avoid spurious responses due to aliasing. However, artifactual responses due to other causes may still occur for bone-conduction stimuli 50 dB HL and higher (and possibly for high-level air conduction). Because the phases of these spurious responses do not invert with inversion of stimulus, the possibility of nonauditory physiologic responses cannot be ruled out. The clinical implications of these results are that artifactual responses may occur for any patient for bone-conduction stimuli at levels greater than 40 dB HL and for high-intensity air-conduction stimuli used to assess patients with profound hearing loss.

Acoustic Stimulation↗

PubMed2004

Brain stem and cortical mechanisms underlying the binaural masking level difference in humans: an auditory steady-state response study.

OBJECTIVE: The behavioral binaural masking level difference (BMLD) is believed to reflect brain stem processing. However, this conflicts with transient auditory evoked potential research that indicates the auditory brain stem and middle latency responses do not demonstrate the BMLD. The objective of the present study is to investigate the brain stem and cortical mechanisms underlying the BMLD in humans using the brain stem and cortical auditory steady-state responses (ASSRs). DESIGN: A 500-Hz pure tone, amplitude-modulated (AM) at 80 Hz and 7 (or 13) Hz, was used to elicit brain stem and cortical ASSRs, respectively. The masker was a 200-Hz-wide noise centered on 500 Hz. Eleven adult subjects with normal hearing were tested. Both ASSR (brain stem and cortical) and behavioral thresholds for diotic AM stimuli (when the signal and noise are in phase binaurally: SoNo) and dichotic AM stimuli (when either the signal or noise is 180 degrees out-of-phase between the two ears: SpiNo, SoNpi) were investigated. ASSR and behavioral BMLDs were obtained by subtracting the threshold for the dichotic stimuli from that for the diotic stimuli, respectively. Effects for modulation rate, signal versus noise phase changes, and behavioral versus ASSR measure on the BMLD were investigated. RESULTS: Behavioral BMLDs (mean = 8.5 to 10.5 dB) obtained are consistent with results from past research. The ASSR results are similar to the pattern of results previously found for the transient auditory brain stem responses and the N1-P2 cortical auditory evoked potential, in that only the cortical ASSRs (7 or 13 Hz) demonstrate BMLDs (mean = 5.8 dB); the brain stem ASSRs (80 Hz) (mean = 1.5 dB) do not. The ASSR results differ from the previous transient N1-P2 studies, however, in that the cortical ASSRs show a BMLD only when there is a change in the signal interaural phase, but not for changes of noise interaural phase. CONCLUSIONS: Results suggest that brain processes underlying the BMLD occur either in a different pathway or beyond the brain stem auditory processing underlying the 80-Hz ASSR. Results also suggest that the cortical ASSRs have somewhat different neural sources than the transient N1-P2 responses, and that they may reflect the output of neural populations that previous research has shown to be insensitive to binaural differences in noise.

Adult↗

PubMed2003

Normal brief-tone bone-conduction behavioral thresholds using the B-71 transducer: three occlusion conditions.

Behavioral thresholds were measured from 31 adults with normal hearing for 500, 1000, 2000, and 4000 Hz brief tones presented using a B-71 bone oscillator. Three occlusion conditions were assessed: ears unoccluded, one ear occluded, and both ears occluded. Mean threshold force levels were 67, 54, 49, and 41 dB re:1 microN peak-to-peak equivalent in the unoccluded condition for 500, 1000, 2000, and 4000 Hz, respectively (corrected for air-conduction pure-tone thresholds). A significant occlusion effect was observed for 500 and 1000 Hz stimuli. These thresholds may be used as the 0 dB nHL (normal-hearing level) for brief-tone bone-conduction stimuli for auditory brainstem response testing.

Acoustic Stimulation↗

PubMed2002

Intracerebral sources of human auditory steady-state responses.

The objective of this study was to localize the intracerebral generators for auditory steady-state responses. The stimulus was a continuous 1000-Hz tone presented to the right or left ear at 70 dBSPL. The tone was sinusoidally amplitude-modulated to a depth of 100% at 12, 39, or 88 Hz. Responses recorded from 47 electrodes on the head were transformed into the frequency domain. Brain electrical source analysis treated the real and imaginary components of the response in the frequency domain as independent samples. The latency of the source activity was estimated from the phase of the source waveform. The main source model contained a midline brainstem generator with two components (one vertical and lateral) and cortical sources in the left and right supratemporal plane, each containing tangential and radial components. At 88 Hz, the largest activity occurred in the brainstem and subsequent cortical activity was minor. At 39 Hz, the initial brainstem component remained and significant activity also occurred in the cortical sources, with the tangential activity being larger than the radial. The 12-Hz responses were small, but suggested combined activation of both brainstem and cortical sources. Estimated latencies decreased for all source waveforms as modulation frequency increased and were shorter for the brainstem compared to cortical sources. These results suggest that the whole auditory nervous system is activated by modulated tones, with the cortex being more sensitive to slower modulation frequencies.

Acoustic Stimulation↗

PubMed2002

Effects of sensorineural hearing loss on cortical event-related potential and behavioral measures of speech-sound processing.

OBJECTIVE: To investigate systematically the effects of sensorineural hearing loss on cortical event-related potentials (ERPs) N1, MMN, N2 and P3 and their associated behavioral measures (d' sensitivity and reaction time) to the speech sounds /ba/ and /da/ presented at 65 and 80 dB ppe SPL. DESIGN: Cortical ERPs were recorded to /ba/ and /da/ speech stimuli presented at 65 and 80 dB ppe SPL from 20 normal-hearing adults and 20 adults who are hearing impaired. The degree of sensorineural impairments at 1000 to 2000 Hz ranged from mild losses (defined as 25 to 49 dB HL) to severe/profound losses (75 to 120 dB HL). The speech stimuli were presented in an oddball paradigm and the cortical ERPs were recorded in both active and passive listening conditions for each stimulus intensity. RESULTS: Both ERP amplitudes and behavioral discrimination (d') scores were lower for listeners with sensorineural hearing loss than for those with normal hearing. However, these differences in response strength were evident only for those listeners whose average hearing loss at 1000 to 2000 Hz exceeded 60 dB HL for the lower intensity stimuli and exceeded 75 dB HL for the higher intensity stimuli. In contrast, prolongations in the ERP and behavioral latencies, relative to responses from normal-hearing subjects, began with even mild (25 to 49 dB HL) threshold elevations. The amplitude and latency response changes that occurred with sensorineural hearing loss were significantly greater for the later ERP peaks (N2/P3) and behavioral discrimination measures (d' and RT) in comparison with earlier (N1, MMN) responses. CONCLUSIONS: The results indicate that latency measures are more sensitive indicators of the early effects of decreased audibility than are response strength (amplitude, d' or percent correct) measures. Sensorineural hearing loss has a greater impact on higher level or "nonsensory" cortical processing in comparison with lower level or "sensory" cortical processing. Possible physiologic mechanisms within the cortex that may be responsible for these response changes are presented. Lastly, the possible clinical significance of these ERP and behavioral findings is discussed.

Adult↗

PubMed2002

Place specificity of multiple auditory steady-state responses.

Auditory steady-state responses (ASSRs) were elicited by simultaneously presenting multiple AM (amplitude-modulated) tones with carrier frequencies of 500, 1000, 2000, and 4000 Hz and modulation frequencies of 77, 85, 93, and 102 Hz, respectively. Responses were also evoked by separately presenting single 500- or 2000-Hz AM tones. The objectives of this study were (i) to determine the cochlear place specificity of single and multiple ASSRs using high-pass noise masking and derived-band responses, and (ii) to determine if there were any differences between single- and multiple-stimulus conditions. For all carrier frequencies, derived-band ASSRs for 1-octave-wide derived bands ranging in center frequency from 0.25 to 8 kHz had maximum amplitudes within a 1/2 octave of the carrier frequency. For simultaneously presented AM tones of 500, 1000, 2000, and 4000 Hz, bandwidths for the function of derived-band ASSR amplitude by derived-band center frequency were 476, 737, 1177, and 3039 Hz, respectively. There were no significant differences when compared to bandwidths of 486 and 1371 for ASSRs to AM tones of 500 or 2000 Hz presented separately. Results indicate that ASSRs to moderately intense stimuli (60 dB SPL) reflect activation of reasonably narrow cochlear regions, regardless of presenting AM tones simultaneously or separately.

Acoustics↗