A defect in corticosteroid-induced IL-10 production in T lymphocytes from corticosteroid-resistant asthmatic patients.
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Biomedical subjects
Publications and source records attributed to David Richards.
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Many variables affect treatment planning, and it is important for clinicians to consider why they plan certain procedures for patient care. New materials, technologies, and products are constantly being introduced and affect decision making in dentistry. In addition, patients are more informed, have higher esthetic concerns, and want a greater stake in treatment planning decisions than ever before. How dentists treatment plan needs to reflect the many influences on final treatment outcome. The purpose of this paper is to outline how treatment planning has changed in dentistry with the goal of providing the general dentist updated information to develop a cohesive treatment plan.
There are several factors to consider when restoring failing dentition in the anterior region. While a tooth can be replaced with an implant, achieving an esthetic result is challenging. The dental team must evaluate numerous criteria to define the optimal treatment plan. Among the considerations are whether to extract the tooth and perform immediate implant replacement or to perform a ridge preservation procedure. This article presents diagnostic determinants to help decide the most appropriate course of therapy to achieve functional and esthetic results.
BACKGROUND AND OBJECTIVE: To compare double-plate Molteno (DPM) with the Ahmed glaucoma valve (AGV) in the treatment of eyes with complicated glaucoma. PATIENTS AND METHODS: This matched, retrospective, case-control study was based on diagnosis, number of previous operations, and age. There were 30 patients in each group and only patients with a minimum of 6 months follow up were included. Double-plate Molteno or Ahmed glaucoma valve insertion was performed on each patient to control intractable glaucoma. Success was defined as IOP <22 mm Hg and >4 mm Hg on the last two visits, a decrease of no more than 2 lines in the visual acuity, and no additional surgical intervention to control IOP. RESULTS: The Kaplan-Meier estimated probability of success at 12 and 24 months was 73% and 56% with DPM and 60% and 50% for AGV (P = 0.72). Mean IOP measured 13.36 +/- 5.2 mm Hg following DPM and 16.7 +/- 5.6 mm Hg following AGV at 12 months (P = 0.026) and 13.3 +/- 5.1 mm Hg with DPM and 19 +/- 5.8 mm Hg with AGV at 24 months (P = 0.009). Of the patients involved in the study, 83.5% exhibited hypertensive phase (HP) of AGV vs 43.5% of DPM (P = 0.04). AGV had a tendency to fail earlier (5 months +/- 7 following AGV vs 13 months +/- 13 following DPM, P = 0.07, t-test). Patients with either a second valve insertion or valve removal were 7/30 of AGV vs 1/30 in DPM (P = 0.05). Stent removal was needed by 10/30 DPM and 8/30 AGV had needling/5-FU. CONCLUSIONS: The percentage of patients free from failure was similar between the two groups at 36 months. DPM is associated with lower mean IOP in the long term compared to AGV.
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