Biomedical subjects

David S Foley

Publications and source records attributed to David S Foley.

6 recordsLinked to original sources

PubMed2006

Thyroglossal duct and other congenital midline cervical anomalies.

Thyroglossal duct anomalies and dermoid cysts comprise the vast majority of congenital midline cervical masses seen in children. Unusual lesions of the midline neck include ranulae and midline cervical clefts. Workup and management is lesion-dependent, and an accurate preoperative diagnosis is essential for planning and performing an appropriate surgical procedure. This discussion presents an overview of the relevant embryology, pathophysiology, and diagnostic modalities for these congenital midline cervical anomalies. Additionally, the current principles of surgical management are described.

Branchial Region↗

PubMed2004

Using a bioabsorbable copolymer plate for chest wall reconstruction.

Reconstruction of the chest wall in a child is an uncommon problem for pediatric surgeons. The available material for chest wall reconstruction typically has been borrowed from the adult experience. The authors describe their recent experience with a commercially available bioabsorbable plate in a variety of conditions that require chest wall reconstruction.

Absorbable Implants↗

PubMedDate not supplied

Perfusion induced hyperthermia for oncologic therapy with cardiac and cerebral protection.

Cancer can be preferentially damaged and killed at temperatures above 41.0 degrees C. However, the heart and brain malfunction at this temperature, limiting the application of systemic hyperthermia in the treatment of metastatic cancer. We created a hyperthermic perfusion system that maximizes the temperature differential produced and extends the safe hyperthermic time. Mongrel dogs were anesthetized and mechanically ventilated. Temperature probes were placed in the rectum, bladder, peritoneal cavity, proximal aorta, pulmonary artery, and right tympanic canal. Venoarterial perfusion was instituted and the perfusate was warmed to 44 to 45 degrees C. The dogs' rectal temperature was elevated to > or = 42 degrees C for 4 hours. A small amount of venous blood was cooled to 28 to 30 degrees C and reperfused into the right atrium to maintain the pulmonary artery temperature < or = 38 degrees C. At the end of the perfusion, the dogs were decannulated, recovered, and returned to their cages for observation. Ten of 11 dogs survived the operative procedure, and no neurologic deficits were observed. The rectal temperature was successfully elevated to > or = 42 degrees C for 4 hours while maintaining the heart and brain at < or = 38 degrees C. Moderate serum biochemical changes were observed postprocedure. However, only the aspartate transaminase and alkaline phosphatase levels remained elevated above both the baseline and canine reference values by day 7. Lower abdominal and pelvic hyperthermia at 42 degrees C can be safely produced and maintained for 4 hours using an extracorporeal perfusion circuit, while protecting the heart and brain from temperature elevation.

Animals↗

PubMedDate not supplied

A review of 100 patients transported on extracorporeal life support.

Between May 1990 and January 1999, 100 patients (68 adult, 32 pediatric) with severe respiratory or cardiac instability were successfully transported to the University of Michigan Medical Center on extracorporeal life support. Diagnoses included adult respiratory distress syndrome (n = 78), cardiac failure (n = 7), sepsis (n = 7), asthma (n = 5), respiratory distress syndrome (of newborn) (n = 2), and airway compromise (n = 1). Of the patients, 53 were supported with venovenous bypass and 47 with venoarterial bypass. Patients were transported by ground ambulance (n = 80), helicopter (n = 15), or fixed-wing aircraft (n = 5). The median transport distance was 44 miles (range 2-790 miles), and the median transport time was 5 hours and 30 minutes (range: 1 h 33 min to 16 h 6 min). Sixty-six patients (66%) survived to discharge. One death occurred during cannulation, and two patients died before cannulation began. Complications that occurred during transport included 10 cases of electrical failure, 3 cases of circuit tubing leakage, and 1 case each of circuit rupture, membrane lung thrombosis, and membrane lung leakage. None of the complications occurring during transport had an adverse effect on outcome. We conclude that the long distance transport of patients on extracorporeal life support can be safely accomplished and is an effective option for the unstable patient with severe respiratory or cardiac failure.

Adult↗

PubMedDate not supplied

Total liquid ventilation: dynamic airway pressure and the development of expiratory flow limitation.

Expiratory flow limitation occurs during total liquid ventilation (TLV), and is characterized by the sudden development of excessively negative intratracheal pressures without increases in flow. The purpose of this study was to identify a dynamic signal for the servoregulation of expiratory flow (Ve), by determining the range of dynamic intratracheal pressures [P(T)], which mark the onset of flow limitation during liquid expiration, where choke occurs at the critical pressure (Pc). The lungs of rabbits were filled with perflurocarbon to an end-inspiratory lung volume (EILV) of 20, 30, or 40cc/kg and connected to a piston driven liquid ventilator, which removed perfluorocarbon at a rate (Vs) of 2.5, 5.0, or 7.5 ml/s. Nine animals per EILV group were used (27 animals total), and within each EILV group each (Vs) was used three times. P(T) and (Ve) (T) were measured at the tracheostomy tube, and dP/dT was calculated from P(T). Pc was determined within each EILV/(Vs) group by examining the average dP/dT curve for the first significant change from baseline. Pc ranged from -6.02 +/- 1.83 to -9.02 +/- 3.2 mm Hg. In general, the higher the EILV, the more negative the Pc. We conclude that Pc during TLV varies within a limited range in rabbits. These data may be used to maximize expired volume during TLV by sequentially tapering flow rates as this critical range of pressures is approached.

Animals↗

PubMedDate not supplied

Location of flow limitation in liquid-filled rabbit lungs.

The effects of end-inspiratory lung volume (EILV) and expiratory flow rate (Q) on the location of flow limitation in liquid-filled lungs were investigated by measuring pressure along the airways and by radiographic imaging. The lungs of New Zealand white rabbits were filled with perfluorocarbon to the randomly selected EILV of 20, 30, or 40 ml/kg, and the volume was actively drained at one of three Q: 2.5, 5.0, or 7.5 ml/s. The minimum pressures recorded by a movable catheter at locations along the airways show that flow limitation occurred in the main bronchi and trachea, and was independent of EILV and Q. The minimum pressure at the trachea was -80 mm Hg compared with values that were more positive than -10 mm Hg at a location 3 cm distal to the carina for all EILV and Q combinations. This location was confirmed by the lung images. The airway diameters gradually decreased with time, until flow limitation occurred. In airways distal to the collapse, there was not a significant decrease in diameter. Based on these data, we conclude that flow limitation in liquid-filled lungs occurs in the trachea and main bronchi and its location is independent of EILV or Q.

Animals↗