Biomedical subjects

David W Britt

Publications and source records attributed to David W Britt.

5 recordsLinked to original sources

PubMed2004

Do reduced multiples do better?

Dramatic successes in infertility care have allowed millions of previously fertile women to have their own children. However, an epidemic of multiple pregnancies has resulted, with catastrophic increases in morbidity and mortality, and in the economic costs to society. Multifetal pregnancy reduction (MFPR) has been used to decrease fetal number in the late first trimester and has dramatically improved outcomes. Recent data suggest that pregnancies starting with three or four, and in some cases five fetuses, which are reduced to twins, do as well as starting with twins. Patients with triplets do better reduced to twins. Reduction to a singleton is becoming more common, particularly for women over 40. Combining MFPR with chorionic villus sampling in patients over 30 years of age has enabled couples to maximize the health of the resultant children.

Abortion, Spontaneous↗

PubMed2004

Fetal reduction from twins to a singleton: a reasonable consideration?

OBJECTIVE: In the past, our group took the position that we would not provide multifetal pregnancy reduction to a singleton regardless of starting number except for serious maternal medical indications or as a selective termination for diagnosed fetal anomalies. With evidence of increased safety and more women (many aged 40 years or more) asking for counseling about reduction to a singleton, we reviewed our prior reasoning. METHODS: We compared outcomes of 52 first-trimester twin-to-singleton for multifetal pregnancy reduction cases performed by a single operator to twin and singleton data from recent national register studies. RESULTS: Twin-to-singleton reductions represent less than 3% of all cases. Forty of 52 patients were aged 35 years or more, 19 were aged more than 40 years, and 2 were aged more than 50 years (age range 32-54 years). Since 1999, 23 of 28 had chorionic villus sampling before multifetal pregnancy reduction. Fifty-one of 52 reached viability with mean gestational age at delivery of 37.2 weeks. One of 52 patients miscarried (1.9%). Compared with multiple sources of data for twins, the loss rate is lower in twins reduced to a singleton. CONCLUSION: Until recently, multifetal pregnancy reductions to a singleton were rare. Physicians were concerned about the unknown risks of multifetal pregnancy reduction in this situation. They also had moral doubts about the justification to go "below twins." However, physicians know that spontaneous twin pregnancy losses average 8-10%. Also, with experience, multifetal pregnancy reduction has become very safe in our hands. Our data suggest that the likelihood of taking home a baby is higher after reduction than remaining with twins. We propose that twin-to-singleton reductions might be considered with appropriate constraints and safeguards.

Abortion, Spontaneous↗

PubMed2002

The genomic revolution and the obstetrician/gynaecologist: from societal trends to patient sessions.

A major aspect of reaping the benefits of the genome revolution in women's health relates to questions of how we are going to handle this scientific manna of information and potential treatment options while minimizing social exclusion along the lines of race, class and gender. Four society-level scenarios or patterns of diffusion of genomic access are discussed, each with its own set of assumptions and outcomes in terms of equity. Like it or not, the front-line obstetrician/gynaecologist will play a critical role in whether such new information helps either to reduce or to exacerbate discrepancies in health-care status along the lines of race and socio-economic status. Patients must not be denied access to knowledge and information within the genetic counselling session, or to the opportunity to make an informed autonomous decision because of the use of unfamiliar language and conventions of conversation that support power differentials and discourage rapport and empathy. Aspects of communication that are critical to the outcome of the genetic counselling session, such as the level of directness of counselling, physician interruptions of the patient and the power implications of the rhetorical question, are explored. In addition, the special challenges to counsellor neutrality and patient autonomy offered by the longitudinal primary obstetrician/gynaecologist relationship are discussed. Strategies encouraging more effective collaboration and communication between generalist and patient in the counselling session are offered.

Communication↗

PubMedDate not supplied

Outreach: targeting high-risk women through community partnerships.

The need for community-based preventive intervention is driven by the ineffectiveness and the costliness of traditional approaches. We argue that community outreach efforts should be characterized by three components: 1) careful mapping of high-risk areas, 2) developing partnerships with trusted community institutions within areas of high risk, and 3) developing a portfolio of institutional partners that maximize the penetration of high-risk populations. The analysis of these high-risk contexts redirects the focus from individuals to institutional structures. Gaining a greater understanding of how impoverished women relate to formal institutions is critical to the primary goal of reducing unnecessary deaths.

Community Health Planning↗

PubMedDate not supplied

Framing the decision: determinants of how women considering multifetal pregnancy reduction as a pregnancy-management strategy frame their moral dilemma.

OBJECTIVE: How people make decisions regarding medical technologies and procedures are affected by how they 'frame' those decisions. Medical frames are characterized by a reliance on statistics regarding outcomes and risk to mother and surviving embryos, emphasize the influence of medical authorities, and are driven by a desire to minimize medical risks. Moral frames, on the other hand, are driven more by a desire to minimize the disruption to antiabortion and antireduction moral precepts, and weight heavily the advice of religious leaders. These frames contest with one another. Our objective is to examine the biographical determinants of frame dominance in this contest as it applies to multigestation pregnancies where selective reduction is being considered as a pregnancy-management strategy. METHODS: For a sample of 55 multigestation women considering multifetal reduction as a pregnancy-management strategy, we develop a distinction between medical and moral frames. Semistructured interviews generated qualitative data that were independently coded by two researchers. These variables were then analyzed using dummy variable regression analysis. RESULTS: Conceptualizing these frames as anchoring opposite ends of a continuum, we show that 40% of the variance in frame dominance can be accounted for by three factors: how involved patients are in religious institutions that have antiabortion norms, whether they have medico-scientific careers, and how pro-reduction their advice has been from fertility specialists and obstetricians prior to coming to the clinic. CONCLUSIONS: The implication of these results for practice include recognizing the wide variation in patient's perceptions of their situations and how these perceptual frames alter how women confront risk-benefit statistics and being flexible in one's approach to counseling patients. This approach can further serve as a model for similar reproductive-health dilemmas.

Career Choice↗