Biomedical subjects

Dean Wu

Publications and source records attributed to Dean Wu.

4 recordsLinked to original sources

PubMed2007

Mixed alien hand syndrome coexisting with left-sided extinction secondary to a left corpus callosal lesion: a case report.

Alien hand syndrome (AHS) is actually two distinct syndromes with distinct clinical and anatomic features, that is, a frontal type and a callosal type. Frontal AHS occurs in the dominant hand; is associated with reflexive grasping, groping, and compulsive manipulation of tools. Callosal AHS is characterized primarily by intermanual conflict. We report a case of right frontal AHS and left callosal AHS (mixed AHS) secondary to ischemic stroke of the left corpus callosum (lesion extending from the genu to splenium) and right corpus callosum (minimal lesion in the splenium) in a 67-year-old male patient who also presented with left-sided tactile extinction. To our knowledge, rare reports have documented mixed AHS coexisting with nondominant side extinction secondary only to unilateral (left) callosal lesion, as in our case.

Aged↗

PubMed2006

Cerebral venous thrombosis initially presenting with acute subarachnoid hemorrhage.

We report the case of a 44-year-old man with superior sagittal and transverse sinus thrombi, who initially presented with venous subarachnoid hemorrhage over the right parietal sulci. After 7 days of intravenous anticoagulation therapy, his condition stabilized. Cerebral venous thrombosis can be difficult to diagnose and is further complicated when patients initially present with acute subarachnoid hemorrhage. A high index of clinical suspicion is needed to diagnose venous subarachnoid hemorrhage so that appropriate treatment can be initiated as promptly as possible.

Adult↗

PubMed2006

Postictal aphasia with transient sulcal hyperintensity on MRI.

A 38-year-old man had postictal global aphasia after generalized tonic-clonic seizure, but recovered within 1 day. There was a focal increase in the signal intensity of the left frontoparietal sulci on fluid-attenuated inversion recovery magnetic resonance (MR) sequence 6 hours after the seizure, which disappeared 1 month later. The transient seizure-induced MR hyperintensity was possibly caused by ictal or postictal hyperemia and breakdown of the blood-brain barrier. This report aims to increase awareness of this condition and avoid unnecessary management.

Adult↗

PubMed2004

[Another seizure classification--Semiological Seizure Classification].

The International League Against Epilepsy (ILAE) introduced in 1981 a seizure classification based on clinical semiology, interictal EEG findings, and ictal EEG patterns. Such classification depends heavily on detailed electroclinical correlation. After 20 years' progress in epileptology, many clinicians have found it difficult to make a "definite" seizure diagnosis clinically without a series of electrophysiological examinations, particularly in the infants, and further advancement in epileptology has findings have made the previous classification inefficient. Lüders and colleagues have proposed a classification, Semiological Seizure Classification (SSC), based exclusively on ictal semiology, which was published in the official journal of ILAE-EPILEPSIA in 1998. The EEG, neuroimaging and other laboratory results should be analyzed separately and then integrated to define the epileptic syndromes. The seizure diagnosis is thus made through a "what-you-see-is-what-you-get" way. It has also provoked an extensive discussion about the necessity of this new classification. In this review, we present the original guideline, which has been used at The Cleveland Clinic Foundation for years, to introduce another method of epileptic seizure classification.

Adult↗