Biomedical subjects

Deborshi Sharma

Publications and source records attributed to Deborshi Sharma.

5 recordsLinked to original sources

PubMed2005

Apoptosis: a basic physiologic process in wound healing.

Apoptosis, or programmed cell death, is a complex network of biochemical pathways for controlling such events in a cell. Apoptosis is essential, as its failure can lead to disease. Because apoptosis concerns the regulation of sequential events, including the removal of inflammatory cells and the evolution of granulation tissue into scar tissue, it has an essential role in wound repair. This article examines the literature and proposes that apoptosis features in the development of diabetic foot wounds. Hyperglycemia deregulates the sequential apoptotic events by multiple mechanisms, leading to delayed wound healing. Deregulated apoptosis is emerging as a prominent cause of delayed wound healing, especially in diabetic wounds, along with the well-known triad of peripheral vascular disease, neuropathy, and infection.

Apoptosis↗

PubMed2004

Tuberculous gastric perforation: report of a case.

A 21-year-old woman presented with a 2-day history of acute abdominal pain. Contrast-enhanced computed tomography (CT) showed a perforation in the lesser curve of the stomach. The patient suffered a bout of hematemesis, following which an endoscopy showed a bleeding blood vessel at the edge of the perforation. We performed an emergency distal gastrectomy, including the ulcer site. Histopathological examination revealed tuberculous granulation tissue and acid-fast bacilli in the ulcer. The patient was given antituberculosis therapy (ATT) postoperatively, and was well when last seen 1 year 5 months after surgery. We analyzed the clinical data of five cases of tuberculous gastric perforation (TGP), reported between 1948 and 2003, including our patient. The patients ranged in age from 21 to 45 years, with a mean age of 36.8 years (SD +/- 10.21), and a male to female ratio of 3 : 2. The diagnosis was confirmed by surgery or autopsy. Abdominal lymphadenopathy was present in all patients. Gastrectomy was performed in four patients, and two were given ATT. All four patients in the previous reports died of their disease.

Abdominal Pain↗

PubMed2004

Primary leiomyosarcoma of the seminal vesicle.

A case of leiomyosarcoma of the seminal vesicle detected as a prerectal mass on routine per-rectal examination is described in a 37-year-old man. Computed tomography scan confirmed it to be arising from the right seminal vesicle. Per-rectal trucut biopsy showed malignant cells. Radical cystoprostatectomy with bilateral pelvic lymphadenectomy with anterior resection of rectum and urinary diversion with ileal conduit was performed. Microscopic examination of the resected specimen showed moderately differentiated leiomyosarcoma from the seminal vesicle. The patient received adjuvant chemotherapy and sandwiched radiotherapy. He is well and free of tumor 20 months after surgery.

Adult↗

PubMed2003

Case report: Malignant phyllodes tumor of prostate.

Malignant phyllodes tumor of prostate is described in a 78 year old man. He had symptoms of prostatism since six months before developing acute urinary retention, which was relieved by suprapubic cystostomy. Transabdominal ultrasonography showed a few hypoechoic areas in a 120 gm prostate. Serum prostate specific antigen was 2.7 ng/ml. Transrectal trucut biopsy was inconclusive. With a diagnosis of benign hyperplasia of prostate. Transvesical prostatectomy was performed. Postoperative biopsy showed phyllodes tumor of the prostate with metastastic deposits in the anterior abdominal wall. He received chemotherapy with Vincristine, Mitomycin C, Adriamycin and Cisplatin every 21st day for six cycles in addition to orchiectomy. Routine follow up by transabdominal ultrasound at ten months showed space occupying lesions in the liver. Patient succumbed to his disease a few days later.

Aged↗

PubMed2002

Hydronephrotic obstructed kidney mimicking a congenital multicystic kidney: case report with review of literature.

OBJECTIVE: To report a case of obstructed hydronephrotic kidney mimicking a multicystic kidney and to review the literature regarding differentiation of the hydronephrotic variant of multicystic kidney from the obstructed hydronephronic kidney. To suggest a possible algorithm in distinguishing them. METHODS: We have reported a case of a 35-year-old male who presented with dull aching pain and a palpable right-sided cystic flank mass of several years duration. The initial workup suggested a nonfunctioning multicystic kidney while the operative findings and histopathology were suggestive of an obstructed hydroenphrotic kidney with pyelonephritic changes. We searched the literature using the key words hydronephrotic dysplastic kidney and multicystic kidney. RESULTS: A detailed literature search did not reveal any such publication describing the differentiation of the hydronephrotic multicystic dysplastic kidney from the obstructed hydronephrotic kidney of pelviureteral obstruction. We reviewed the existing literature on this subject, on the basis of which, we have suggested a six-stepladder approach to distinguish such cases. CONCLUSION: By using the 6 step ladder protocol algorithm suggested by us one can attempt to distinguish the hydronephrotic variant of multicystic dysplastic kidney from the hydronephrotic kidney due to pelviureteral obstruction in patients presenting with a symptomatic cystic flank masses of renal origin. Differentiation between the two may be difficult at times due to the medial/central placement of cysts in the former. This is necessary since renal salvage may be possible in the latter while timely nephrectomy may be considered in the former to prevent against the hazards of leaving behind a dysplastic kidney in situ.

Adult↗