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Denis Paré

Publications and source records attributed to Denis Paré.

26 records · Page 2Linked to original sources
PubMed2003

Role of the basolateral amygdala in memory consolidation.

Typically, emotionally charged events are better remembered than neutral ones. This paper reviews data indicating that the amygdala is responsible for this facilitation of memory by emotional arousal. Pharmacological and behavioral studies have shown that the release of adrenal stress hormones facilitates memory consolidation. The available evidence suggests that this effect depends on a central action of stress hormones involving the release of the neuromodulators noradrenaline (NA) and acetylcholine in the basolateral complex of the amygdala (BLA). Indeed, BLA lesions block the memory modulating effects of stress hormones. Moreover, microdialysis studies have revealed that BLA concentrations of NA and acetylcholine are transiently (2h) elevated following emotionally arousing learning episodes. Last, post-learning intra-BLA injections of beta-adrenergic or muscarinic receptor antagonists reduce retention. These results have led to the hypothesis that NA and acetylcholine increase the activity of BLA neurons in the hours after the learning episode. In turn, the BLA would facilitate synaptic plasticity in other brain structures, believed to constitute the storage sites for different types of memory. Consistent with this, post-learning treatments that reduce or enhance the excitability of BLA neurons respectively decrease or improve long-term retention on various emotionally charged learning tasks. However, a number of issues remain unresolved. Chief among them is how the BLA facilitates synaptic plasticity elsewhere in the brain. The present review concludes with a consideration of this issue based on recent advances in our understanding of the BLA. Among other possibilities, it is suggested that rhythmic BLA activity at the theta frequency during arousal as well as the uniform conduction times of BLA axons to distributed rhinal sites may promote plasticity in co-active structures of the temporal lobe.

Adrenal Cortex Hormones↗
PubMed2003

Contextual inhibitory gating of impulse traffic in the intra-amygdaloid network.

New data on the organization of the intra-amygdaloid circuit is reviewed, beginning with the basolateral (BL) complex, the main input station of the amygdala for sensory afferents, and concluding with the central (CE) nucleus, an important source of projections to brain-stem structures mediating fear responses. The BL complex is endowed with a highly divergent system of intrinsic glutamatergic connections. Yet, BL projection cells have unusually low firing rates. This apparent contradiction is explained by the presence of powerful inhibitory pressures in the BL amygdala: (1) interneurons that generate large-amplitude inhibitory synaptic potentials and (2) projection cells that express a Ca(2+)-dependent K(+) current that can be activated by subthreshold synaptic inputs. Likewise, excitatory projections from the BL amygdala to the CE nucleus are controlled by clusters of GABAergic neurons, termed the intercalated (ITC) cell masses. In response to BL inputs, ITC cells generate feedforward inhibition in CE neurons. However, ITC neurons exhibit properties that allow them to modify the amount of inhibition they generate depending on the distribution of BL activity in space and time. Indeed, ITC cell masses can inhibit each other via lateromedial connections. Moreover, they express an unusual K(+) conductance that modifies their response to BL inputs depending on their recent firing history. Thus, inhibitory mechanisms of the amygdala allow for flexible, context-dependent gating of BL impulses to the CE nucleus.

Amygdala↗
PubMed2002

Amygdala oscillations and the consolidation of emotional memories.

The amygdala receives multi-modal sensory inputs and projects to virtually all levels of the central nervous system. Via these widespread projections, the amygdala facilitates consolidation of emotionally arousing memories. How the amygdala promotes synaptic plasticity elsewhere in the brain remains unknown, however. Recent work indicates that amygdala neurons show theta activity during emotional arousal, and various types of oscillations during sleep. These synchronized neuronal events could promote synaptic plasticity by facilitating interactions between neocortical storage sites and temporal lobe structures involved in declarative memory.

Journal Article↗
PubMed2002

Mechanisms of Pavlovian fear conditioning: has the engram been located?

Uncertainty persists as to whether the amygdala is a crucial site of plasticity for classically conditioned fear or merely a sensory relay to structures generating fear responses. A recent Nature study suggests that associative synaptic changes take place in neurons of the amygdala during fear conditioning, and that these changes require dopamine-mediated modulation. Nevertheless, these findings do not prove that the amygdala is a sufficient site of plasticity for fear memory.

Amygdala↗
PubMed2002

Physiological properties of central amygdala neurons: species differences.

The connections of limbic structures are remarkably constant across species. However, different species express fear in distinct ways. Because the central amygdaloid nucleus is considered an important mediator of fear responses, we compared the physiological properties of central amygdala neurons in guinea pigs, rats and cats using whole-cell recordings in coronal slices in vitro. In guinea pigs, most central medial and lateral neurons displayed an outward rectification that delayed firing onset in response to depolarizing current pulses (hence the designation late-firing neurons). Late-firing neurons were also prevalent in the lateral sector of the cat central nucleus. In contrast, late-firing neurons were rare in the rat central nucleus and the cat central medial nucleus. There, most neurons generated Ni2+-sensitive low-threshold bursts of Na+ spikes and/or displayed pronounced inward rectification in the hyperpolarizing direction. Species differences in passive properties were also observed, but they were mainly related to the relative prevalence of late-firing cells. Indeed, late-firing cells had a significantly lower input resistance and more negative membrane potential than other types of central neurons. Thus, there are marked species differences in the physiological properties of central neurons. Because the synaptic responsiveness of neurons is constrained by their physiological properties, our findings raise the possibility that the contrasting behavioural responsiveness observed across species is partly dependent on the species-specific physiological properties of central neurons.

Action Potentials↗
PubMed2002

Uniform range of conduction times from the lateral amygdala to distributed perirhinal sites.

Much data indicate that the perirhinal (PRH) cortex plays a critical role in declarative memory and that the amygdala facilitates this process under emotionally arousing conditions. However, assuming that the amygdala does so by promoting Hebbian interactions in the PRH cortex is hard to reconcile with the fact that variable distances separate amygdala neurons from their PRH projection sites. Indeed, to achieve a synchronized activation of distributed PRH sites, amygdala axons should display a uniform range of conduction times, irrespective of distance to target. To determine if amygdala axons meet this condition, we measured the antidromic response latencies of lateral amygdala (LA) neurons to electrical stimuli delivered at various rostrocaudal levels of the PRH cortex in cats anesthetized with isoflurane. Although large variations in antidromic response latencies were observed, they were unrelated to the distance between the PRH stimulation sites and LA neurons. To determine whether this result was an artifact due to current spread, two control experiments were performed. First, we examined the antidromic response latency of intrinsic PRH neurons. Although we used the same methods as in the first experiment, the antidromic response latency of PRH neurons to electrical stimuli applied in the PRH cortex increased linearly with the distance between the stimulating and recording sites. Second, we measured the antidromic response latency of PRH neurons projecting to the LA. In this pathway, we also found a statistically significant correlation between conduction times and distance to target. Thus these results support the intriguing possibility that the conduction velocity and/or trajectory of LA axons are adjusted to compensate for variations in distance between the LA and distinct rostrocaudal PRH sites. We hypothesize that because of their uniform range of conduction times to the PRH cortex, LA neurons can generate short time windows of depolarization facilitating Hebbian associations between coincident, but spatially distributed, activity patterns in the PRH cortex. In this context, the temporal scatter of conduction times in the LA to PRH pathway is conceived as a mechanism used to lengthen the period of depolarization to compensate for conduction delays within intrinsic PRH pathways. In part, this mechanism might explain how the amygdala promotes memory storage in emotionally arousing conditions.

Amygdala↗
PubMedDate not supplied

Lasting increases in basolateral amygdala activity after emotional arousal: implications for facilitated consolidation of emotional memories.

Manipulations that reduce or enhance the activity of basolateral amygdala (BLA) neurons in the minutes to hours after training have been shown to respectively impair or facilitate retention on the inhibitory avoidance task. Although this suggests that BLA activity is altered after emotional arousal, such changes have not been directly demonstrated. To test this, we devised a feline analog of the inhibitory avoidance task and recorded BLA unit activity before and after a single inescapable footshock. Single-unit recordings revealed that the firing rate of many BLA neurons gradually increased after the footshock, peaking 30-50 min post-shock and then subsiding to baseline levels 2 h later. During this period of increased activity, the discharges of simultaneously recorded BLA cells were more synchronized than before the shock. Although it was known that pairing innocuous (conditioned stimulus, CS) and noxious stimuli modifies the responsiveness of BLA neurons to the CS, our results constitute the first demonstration that emotional arousal produces lasting increases in the spontaneous firing rates of BLA neurons. We propose that these changes in BLA activity may promote Hebbian interactions between coincident but spatially distributed activity patterns in BLA targets, facilitating the consolidation of emotional memories.

Action Potentials↗