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Biomedical subjects

Derek L Connolly

Publications and source records attributed to Derek L Connolly.

7 recordsLinked to original sources
PubMed2005

A 'Reveal'ing diagnosis.

The present case report describes a 54-year-old woman with recurrent syncope of undetermined etiology. Despite several cardiological and neurological investigations, no firm diagnosis was established until an insertable loop recorder (REVEAL Plus Model 9526, Medtronic Inc., Minneapolis, MN, USA) revealed muscle twitch artifact secondary to a seizure disorder.

Arrhythmias, Cardiac↗
PubMed2005

Hibernating myocardium in heart failure.

Ischemic left ventricular systolic dysfunction may result from myocardial necrosis or from hypocontractile areas of viable myocardium. In some cases, recovery of contractility may occur on revascularization--this reversibly dysfunctional tissue is commonly referred to as hibernating myocardium. Observational data suggest that revascularization of patients with ischemic left ventricular systolic dysfunction and known viable myocardium provides a survival benefit over medical therapy. Identification of viable, dysfunctional myocardium may be especially worthwhile in deciding which patients with ischemic left ventricular systolic dysfunction will benefit from revascularization procedures. Randomized, prospective trials evaluating this are currently ongoing. This review will provide an overview of the complex pathophysiology of viable, dysfunctional myocardium, and will discuss outcomes after revascularization. Of the techniques used to determine the presence of hibernating myocardium, functional methods such as stress echocardiography and cardiac magnetic resonance appear more specific, but less sensitive, than the nuclear modalities, which assess perfusion and metabolic activity. Currently, the availability of all methods is variable.

Heart Failure↗