Biomedical subjects

Derun Tian

Publications and source records attributed to Derun Tian.

4 recordsLinked to original sources

PubMed2003

[Study on the effect of transcutaneous electric nerve stimulation on obesity].

OBJECTIVE: To evaluate the effect of transcutaneous electrical stimulation produced by Han's acupiont nerve stimulator (HANS) in treating obesity. METHODS: Sixteen volunteers with primary obesity were recruited, without any instructions or attempts to control their dietary. The trial started in November 2001 and ended in June 2002. Each obese volunteer received transcutaneous electric nerve stimulation (TENS) at 8 acupoints. The electrical parameters were: frequency at 2 Hz, with pulses width of 0.6 ms; intensity varied depending on individual's sensitivity to electrical stimulation to maintain a comfortable level. The treatment was administered 3 times per week. Body weight was recorded before each TENS treatment. RESULTS: The main value of body weight decreased gradually during the trial, with a net decrease of (2.06 +/- 0.31) kg at the end of 12 weeks' treatment (the first phase), corresponding to a decrease of (2.78 +/- 0.40)% as compared with the initial body weight (P < 0.01). In the interim period of 4 weeks (during the Chinese Spring Festival), a partial recurrence of the body weight occurred. During the second phase of treatment lasting for 15 weeks, there was again a reduction of body weight for (2.81 +/- 0.68) kg, corresponding to a decrease of (3.90 +/- 0.40)% (P < 0.001) as compared with the pretreatment level. CONCLUSION: An open trial of HANS treatment revealed a moderate, but significant effectiveness on weight reduction in a group of people with primary obesity. The therapy remains effective for the second phase of treatment. It is anticipated that a better effect can be achieved if the treatment is accompanied with diet control and appropriate exercise.

Acupuncture Points↗

PubMed2003

[Electroacupuncture up-regulated arcuate nucleus alpha-MSH expression in the rat of diet-induced obesity].

OBJECTIVE: To investigate the effect of electroacupuncture (EA) on rat with diet-induced obesity (DIO) and to explore the possible neurochemical mechanisms using the technique of immumohistochemistry. METHODS: To establish DIO rat model by feeding the animals with high fat diet for 14 weeks. DIO rats were randomly divided into 4 groups: (1) 2Hz EA group, (2) 100Hz EA group, (3) restrain control group, (4) diet resistance (DR) group, (5) DIO group and (6) normal control group. EA treatment: (1) The acupoints used were Zusanli and Sanyinjiao on both legs. (2) The intensities of stimulation were 0.5, 1.0 and 1.5mA for 10 mins each. EA treatment was administered 3 times per week. Food intake and body weight were measured daily for 4 weeks. (3) The changes of the expression of alpha-melanocyte-stimulating hormone (alpha-MSH) in the hypothalamic arcuate nucleus (ARC) were measured with immunohistochemical semiquantitative analysis. RESULTS: (1) The food intake and body weight of 2 Hz EA group and 100 Hz EA group were decreased significantly compared with the restrain control group and DIO group. (2) The number of alpha-MSH positive cells in hypothalamic ARC in 2 Hz EA and 100 Hz EA group was significantly higher than that in restrain control group and DIO group. The number of alpha-MSH positive cells in hypothalamic ARC in DIO group is significantly lower than those in DR group or normal control group. CONCLUSION: A decrease of alpha-MSH level in hypothalamus may be associated with diet-induced obesity. The therapeutic effect on obesity produced by EA may be accounted for by the stimulation of pro-opio-melanocortin neurons in hypothalamic ARC to release alpha-MSH, which inhibits food intake, resulting in a decrease of body weight.

Animals↗

PubMed2002

[Microanatomy study on sinus triangle region].

OBJECTIVES: To explore shape and position relationship of the structures with in sinus triangle region, and provide the anatomic foundation for extended presigmoid operative approach. METHODS: Ten cadaveric heads and 15 skull-base specimens fixed with 10% formalin, with aid of operative microscope, the shape and relations of structures with in the sinus triangle region were observed and microphotographed. Four cadaveric heads were sectioned in different plane using collodion embedding process. RESULTS: Jugular blub (JB) had high -placed jugular blub (HJB), normal jugular blub (NJB) and low-placed jugular blub (LJB). The incidence of HJB was 8% and 18% for the left and right sides (P < 0.01). The JB dome can extend upward the hypotympanic cavity and the posterior wall of the internal acoustic meatus. The incidence of NJB and LJB was 36% and 30%, and 6% and 2% respectively. The level distance between the posterior semicircular canal and petrosal posterior surface was (4.1 +/- 1.1) mm. The distance between the JB and vertical part of the facial nerve was (3.2 +/- 0.5) mm and (2.0 +/- 0.4) mm. The distance between the JB and posterior margin of the internal acoustic port was (7.5 +/- 1.7) mm and (4.0 +/- 1.0) mm. CONCLUSIONS: Knowing the shape and position relationship of structures in the sinus triangle region is favorable for preserving the important structures in extended presigmoid operative approach.

Autopsy↗

PubMed2002

[Microsurgical anatomy of craniocervical junction region].

OBJECTIVES: To study the shape and the structures in the craniocervical junction region (CCJR) and the safety of far lateral approach. METHODS: Ten cadaveric heads and 20 skull-base specimens were fixed with 10% formalin, and 4 of the 10 cadaveric heads were sectioned in different plane with the aid of operative microscope. The shape and relation of structures in the CCJR were observed. RESULTS: The third segment of the vertebral artery(VA) was 21.6(15.3 31.9) mm. An incomplete bony canal was found to be 15% and complete bony canal surrounding the VA to be 5% on the VA groove. The distance of the left and right VA was 14.3a(c)(9.8 15.2) mm on the entry into the dura. The length of the occipital condyle was 26.8(25.1 28.2) mm, with the thickness of its anterior, middle and posterior one-third part was 9.9(9.6 10.6) mm, 11.2(9.2 13.1) mm and 8.6 (8.3 9.0) mm respectively. The distance between the posterior pole of the occipital condyle and the intracranial orifice of the hypoglossal canal was 9.9(8.6 11.4) mm, and between the posterior pole and the extracranial orifice was 16.1(13.5 17.1) mm. The transverse process of the atlas was the most important bony landmark for the approach. CONCLUSIONS: Knowing the shape and relationship of the VA and occipital condyle in the CCJR is helpful in preserving the important structures in far lateral approach to target region.

Humans↗