Biomedical subjects

Diane M E Sloan

Publications and source records attributed to Diane M E Sloan.

3 recordsLinked to original sources

PubMed2003

Gender differences in depression and response to antidepressant treatment.

Throughout their childbearing years, women are twice as likely as men to experience an episode of major depression. The exact etiology of this difference is unclear, but psychosocial and neurobiologic factors likely contribute. Clinicians should consider gender differences in the phenomenology of depression and response to antidepressant treatment when screening for depressive illness, selecting appropriate treatment and assessing therapeutic response. Treatment considerations when selecting an antidepressant should include the patient's gender, age, and, in women, menopausal status, including the use of concomitant HRT. Further research is needed to refine and extend the existing knowledge base regarding the effect of gender on treatment of depression, including the role of endogenous and exogenous gonadal hormones in response to antidepressant treatment.

Adult↗

PubMed2002

Remission as the critical outcome of depression treatment.

Major depressive disorder is currently the fourth largest contributor to the worldwide burden of disease. Direct and indirect costs associated with depression place a significant burden on the health care system and society. Despite the development of new antidepressant medications, the management of patients with depression remains a therapeutic challenge. Obtaining a response in antidepressant therapy-commonly defined in clinical trials as an improvement of >erotonergic and noradrenergic neurotransmission, will increase the likelihood of remission.

Antidepressive Agents↗

PubMed2002

Gender-specific differences in depression and treatment response.

Epidemiologic studies have shown that the prevalence of depression is about twice as high in women than in men. Both neurobiologic and psychosocial factors may contribute to this difference. Gender differences in depression have also been noted with regard to symptom presentation, comorbid disorders, course of illness, and response to treatment. This article provides an overview of gender differences in the phenomenology and treatment of depression, particularly the effect of gender on antidepressant treatment response. Clinicians should consider gender as a factor in both the assessment and treatment of depression.

Antidepressive Agents↗