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Biomedical subjects

Diya F Mutasim

Publications and source records attributed to Diya F Mutasim.

At least 19 recordsLinked to original sources
PubMed2006

Mycosis fungoides presenting as reticular erythematous mucinosis.

BACKGROUND: Mycosis fungoides has numerous clinical presentations. METHODS: We present two cases in which mycosis fungoides clinically mimicked reticular erythematous mucinosis. RESULTS: Both patients had extracutaneous involvement. One had a fatal outcome. CONCLUSIONS: We suggest that full systemic evaluation be performed at the time of presentation of patients with this variant of mycosis fungoides.

Aged↗
PubMed2006

Autoimmune bullous diseases: diagnosis and management.

Autoimmune bullous diseases are a heterogenous group of diseases characterized by cutaneous and mucosal vesicles and bullae. Diagnosis is based on a combination of clinical, histopathological, and immunofluorescence findings. Current treatment, including vigilant wound care, significantly reduces disease morbidity and mortality.

Anti-Inflammatory Agents↗
PubMed2006

Primary cutaneous adenoid cystic carcinoma: a case report and literature review.

Primary cutaneous adenoid cystic carcinoma (ACC) is a rare tumor, with less than 50 cases reported to date. We report an additional case of primary cutaneous ACC arising on the scalp of a 57-year-old woman. The clinical presentation, histologic findings, and subsequent treatment are described. A brief review of the literature is provided.

Carcinoma, Adenoid Cystic↗
PubMed2005

Benign cutaneous epithelioid Schwannoma: case report and review of the literature.

Benign peripheral nerve sheath tumors are relatively common. They are mostly characterized by the presence of delicate S-shaped spindle cells and myxoid stroma. Although variants with epithelioid foci can be present, the pure epithelioid variant of benign cutaneous schwannoma is extremely rare. It was first reported as cutaneous epithelial schwannoma by Kindblom et al in 1998. Since then, only six cases have been reported. Care should be taken not to misdiagnose them as malignant neoplasms. Their diagnosis can be problematic as their histopathologic features may overlap with those of other soft-tissue and melanocytic tumors. We report a case of cutaneous epithelioid schwannoma and review of the literature.

Biomarkers, Tumor↗
PubMed2005

Topical protease therapy as a novel method of epidermal ablation: preliminary report.

BACKGROUND: For more than 50 years, proteolytic enzymes have been extensively used in laboratory settings for the purposes of in vitro epidermal separation and keratinocyte isolation. However, the topical, in vivo pharmacologic properties of these enzymes are virtually unknown. Previous therapeutic applications for topically applied proteases have been limited to wound debridement. OBJECTIVE: To characterize the clinical and histologic effects of topically applied proteases as a method of therapeutic epidermal ablation. MATERIALS AND METHODS: SKH-1 hairless mouse and human skin samples were exposed both in vitro and in vivo to varying concentrations of the proteases subtilisin, trypsin, and dispase for different exposure durations. The effects of protease exposure were then assessed by both clinical and histologic examination. RESULTS: Exposure of both human and mouse skin samples to topical protease solutions resulted in reproducible, differential patterns of epidermal ablation: subcorneal, intraepidermal, and subepidermal. In a limited study, topical application of trypsin solution resulted in the scar-free ablation of lesions of seborrheic keratosis located on the lower extremity. CONCLUSION: Topically applied proteases represent an alternative method of epidermal ablation with several potential advantages over existing techniques. Further studies are needed to delineate ideal enzyme formulations, vehicles, and applications.

Administration, Cutaneous↗
PubMed2005

Sarcoidosis mimicking lipodermatosclerosis.

The clinical presentation of cutaneous sarcoidosis is highly variable. Rare presentations include ulcerated plaques, morpheaform lesions, and unilateral lower extremity edema. We report the case of a woman who presented with unilateral ulcerating sarcoidosis of the lower leg with progressive fibrosis and edema mimicking lipodermatosclerosis. This case is unique in that the patient exhibited all 3 of the rare manifestations of sarcoidosis; to our knowledge, this presentation has not been previously reported in the literature.

Anti-Inflammatory Agents↗
PubMed2004

Management of autoimmune bullous diseases: pharmacology and therapeutics.

Bullous diseases are associated with high morbidity and mortality. They result from autoimmune response to one or more components of the basement membrane or desmosomes. Management consists of treating the immunologic basis of the disease, treating the inflammatory process involved in lesion formation, and providing supportive care both locally and systemically. Therapeutic agents are chosen based on their known pharmacologic properties and evidence of effectiveness derived from observations and studies. Learning objectives At the completion of this learning activity, participants should be able to understand the pharmacology of drugs used in the treatment of bullous diseases, the principles of therapy for various such diseases, and a practical approach to the management of these diseases.

Autoimmune Diseases↗
PubMed2004

A case of intraepidermal Merkel cell carcinoma within squamous cell carcinoma in-situ: Merkel cell carcinoma in-situ?

We report a case of a 79-year-old Caucasian male who presented with a wrist lesion of combined intraepidermal Merkel cell carcinoma and squamous cell carcinoma in-situ. The two tumors were tightly admixed and distinct, and both were without any dermal or invasive components. No features of transition between the two tumors were seen. We suggest the term Merkel cell carcinoma in situ for tumors that demonstrate exclusive intraepidermal proliferation of neuroendocrine cells.

Biomarkers, Tumor↗
PubMed2003

Confluent and reticulated papillomatosis without papillomatosis.

Confluent and reticulated papillomatosis is a papulosquamous disorder that affects young individuals. There are several hypotheses regarding the cause, including genetic keratinization disorder, reaction to pityrosporum, and reaction to UV light. Multiple therapeutic agents have been used with variable success. The histologic findings include papillomatosis, hyperkeratosis, and minimal or no acanthosis. We present a patient with the clinical findings of confluent and reticulated papillomatosis who responded dramatically to minocycline, and in whom histologic examination did not reveal papillomatosis.

Adult↗
PubMed2003

Cutaneous lymphoplasmacytoid lymphoma (immunocytoma) with Waldenström's macroglobulinemia mimicking rosacea.

A 50-year-old woman presented with a 2-year history of facial lesions that were resistant to rosacea therapy. Evaluation of histology, immunohistochemistry, gene rearrangement study, bone-marrow biopsy specimen, and systemic workup revealed the findings of lymphoplasmacytoid lymphoma (immunocytoma) in both the skin lesions and bone marrow, and IgM kappa paraprotein. Lesions cleared after chemotherapy.

Bone Marrow Cells↗
PubMed2003

Colocalization of granuloma annulare and mid-dermal elastolysis.

Mid-dermal elastolysis is an elastic tissue disorder of unknown causation. Various elastic tissue abnormalities have been described in granuloma annulare. To our knowledge, we report the first case illustrating the clinical and histologic colocalization of granuloma annulare and mid-dermal elastolysis.

Adult↗
PubMed2003

Severe subacute cutaneous lupus erythematosus presenting with generalized erythroderma and bullae.

A 31-year-old woman presented with progressive generalized erythroderma and bullae. Histologic evaluation revealed dyskeratosis and interface dermatitis with a paucity of infiltrate. Serologic evaluation revealed markedly elevated titer of Ro/SS-A and La/SS-B antibodies. Further workup revealed leukopenia. The generalized eruption cleared with prednisone. The patient later had the classic discrete lesions of subacute cutaneous lupus erythematosus develop. The erythrodermic and bullous presentation of subacute cutaneous lupus erythematosus is rare and requires a high index of suspicion.

Adult↗
PubMed2003

Bullous autoimmune estrogen dermatitis.

We report a case of bullous eruption secondary to exogenous estrogen. Histology mimicked erythema multiforme. Lesions cleared with discontinuation of estrogen.

Autoimmune Diseases↗