Biomedical subjects

Do-Yeon Cho

Publications and source records attributed to Do-Yeon Cho.

5 recordsLinked to original sources

PubMed2007

Influence of upper airway narrowing on the effective continuous positive airway pressure level.

BACKGROUND AND OBJECTIVES: The aim of this study was to determine the relationship between the continuous positive airway pressure (CPAP) titration level and upper airway variables in obstructive sleep apnea syndrome (OSAS). SUBJECTS AND METHODS: Forty-seven patients suffering from OSAS were enrolled in this study. They were asked to answer a questionnaire about nasal stuffiness and mouth breathing, and the degree of tonsillar hypertrophy and shape of the oropharyngeal inlet were evaluated. The minimal cross-sectional area (MCA) of the nasal cavity was measured with acoustic rhinometry, followed by optimal CPAP level titration. We compared optimal CPAP levels with body mass index (BMI), perceived nasal stuffiness, and anatomic upper airway narrowing. RESULTS: The mean CPAP level was 6.32 +/- 2.17 cm H2O. We found a significant correlation between CPAP levels and BMI (P = .01), apnea-hypopnea index (P = .015), and the degree of tonsillar hypertrophy (P = .011). Furthermore, the CPAP level increased significantly with the MCA on the narrow side of the nasal cavity (P = .038) in patients with a BMI less than 25. Other variables, such as subjective symptoms and anatomic nasal airway occlusion in obese patients (BMI > or = 25), revealed no correlation with the CPAP level. CONCLUSIONS: Upper airway occlusion including nasal obstruction or tonsillar hypertrophy might increase the effective CPAP level.

Adult↗

PubMed2006

Complications of tracheotomy in patients with mucopolysaccharidoses type II (Hunter syndrome).

OBJECTIVE: To investigate the complication rate of tracheotomy in patients with mucopolysacchridoses (MPS) type II (Hunter syndrome). MATERIALS AND METHODS: From 2004 to 2005, seven tracheotomy procedures were performed for the airway management in three patients with MPS type II. The complications for each procedure were analyzed, which included the stomal narrowing, granulation formation, infrastomal tracheal stenosis, and wound infection. RESULTS: All tracheotomies in patients with MPS type II resulted in tracheotomy-related complications, though these procedures secured a safe airway. Infrastomal tracheal stenosis was the most frequent complication (85.7%) and stomal narrowing also occurred frequently (71.4%) after each tracheotomy. These complications caused cannula care to be difficult, with revision frequently required. CONCLUSION: Of the complications observed after tracheotomy, infrastomal tracheal stenosis and stomal narrowing are frequent in patients with MPS type II. Therefore, tracheotomy procedures should be cautiously applied to the MPS type II patients, and the complications associated with tracheotomy should be discussed with caregivers preoperatively.

Adolescent↗

PubMed2006

Sentinel lymph node radiolocalization with 99mTc filtered tin colloid in clinically node-negative squamous cell carcinomas of the oral cavity.

The objective of this study was to evaluate the feasibility of sentinel lymph node biopsy by using a radiotracer lymphatic mapping technique in patients with squamous cell carcinoma of the oral cavity, and the diagnostic value of this technique. We studied twenty patients with previously untreated squamous cell carcinomas of the oral cavity and N0 necks. After the peritumoral injection of 99mTc filtered tin colloid preoperatively, lymphoscintigraphy and intraoperative mapping using a gamma detector were performed to localize sentinel nodes. An open biopsy of the sentinel node was followed by complete neck dissection. We identified the sentinel nodes in 19 of 20 patients (95.0%) by lymphoscintigraphy and in all (100%) by intraoperative gamma detector. In all cases, the status of the sentinel node accurately predicted the pathologic status of the neck with the false negative rate being 0%. The negative predictive value for the absence of cervical metastases was 100%. In conclusion, our radiolocalization technique of sentinel nodes using 99mTc filtered tin colloid in N0 squamous cell carcinomas of the oral cavity is technically feasible and appears to accurately predict the presence of the occult metastatic disease.

Adult↗

PubMed2005

Histopathologic characteristics of chronic sinusitis with bronchial asthma.

CONCLUSION: These findings suggest that patients with both sinusitis and asthma present the histopathologic characteristic of a marked chronic inflammatory reaction, and that eosinophil infiltration may play a significant role in this marked inflammation of the sinus mucosa. OBJECTIVE: Chronic sinusitis and bronchial asthma are known to be closely related. However, the appearance of the mucosa in chronic sinusitis patients with asthma is somewhat different from that in patients without asthma. MATERIAL AND METHODS. We compared the sinus mucosal histopathologies of asthmatic patients with those of non-asthmatic patients. Fifty-three sinusitis patients with a diagnosis of asthma and 54 sinusitis patients without asthma, who served as controls, were enrolled in the study. All of these patients underwent endoscopic sinus surgery. The following seven light microscopic findings were compared in the asthmatic and non-asthmatic groups: the thickness of the basement membrane, goblet cell hyperplasia, subepithelial edema, submucous gland formation, eosinophil infiltration, lymphocyte infiltration and polymorphonuclear leukocyte infiltration. In addition, we explored a possible link between asthma and sinusitis by comparing the following factors in asthmatic and non-asthmatic patients: the presence of allergy, the degree of preoperative polyposis and the extent of preoperative disease as scored by means of ostiomeatal unit CT findings. RESULTS: No statistically significant differences were found between the two groups in terms of the presence of allergy, the degree of preoperative polyposis or the extent of preoperative disease. Basement membrane thickening, goblet cell hyperplasia and eosinophil infiltration were more prominent in the asthmatic compared to the non-asthmatic group (p <0.05).

Adolescent↗

PubMed2004

Clinical usefulness of extratympanic electrocochleography in the diagnosis of Ménière's disease.

OBJECTIVE: Electrocochleography has been introduced to aid the diagnosis of endolymphatic hydrops. The aim of this study was to evaluate the clinical effectiveness of extratympanic electrocochleography in the diagnosis of Ménière's disease. STUDY DESIGN: The medical records of patients diagnosed as having Ménière's disease at the department of otolaryngology were reviewed retrospectively. Thirty-seven healthy ears were included to calculate the upper level of the 95th percentile range of the extratympanic electrocochleography variables. SETTING: Tertiary referral university hospital. PATIENTS: One hundred fifty-eight patients (97 women and 61 men) diagnosed as having Ménière's disease without previous treatments were included. A retrospective analysis of their medical records, electrocochleographic results, audiograms, and follow-up records was performed. The mean age was 48.6 years. MAIN OUTCOME MEASURES: The upper level of the 95th percentile range of the extratympanic electrocochleography variables of normal subjects were calculated. Electrocochleography recording results were compared with the diagnostic scale and stage, presence of fluctuating hearing loss, and duration of symptoms. RESULTS: The 95% upper limit for baseline summating potential and action potential ratio was 0.34. Sensitivity and specificity of electrocochleography in the diagnosis of Ménière's disease were 71% and 96%, respectively. The results statistically correlated with the Ménière's current diagnostic criteria and did not correlate with the stage of disease, presence of fluctuating hearing loss, or duration of symptoms. CONCLUSION: Extratympanic electrocochleography may play an important role, especially in patients with less definite symptoms, but the diagnosis should also be anchored in the patient's clinical history, symptoms, and audiogram.

Adolescent↗