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Dominika Malińska

Publications and source records attributed to Dominika Malińska.

4 recordsLinked to original sources
PubMed2006

Mitochondrial potassium channels: from pharmacology to function.

Mitochondrial potassium channels, such as ATP-regulated or large conductance Ca2+ -activated and voltage gated channels were implicated in cytoprotective phenomenon in different tissues. Basic effects of these channels activity include changes in mitochondrial matrix volume, mitochondrial respiration and membrane potential, and generation of reactive oxygen species. In this paper, we describe the pharmacological properties of mitochondrial potassium channels and their modulation by channel inhibitors and potassium channel openers. We also discuss potential side effects of these substances.

Adenosine Triphosphate↗
PubMed2006

[Mitochondrial ion channels].

Ion channels are proteins, which facilitate the ions flow throught biological membranes. In recent years the structure as well as the function of the plasma membrane ion channels have been well investigated. The knowledge of intracellular ion channels however is still poor. Up till now, the calcium channel described in endoplasmatic reticulum and mitochondrial porine are the examples of intracellular ion channels, which have been well characterized. The mitochondrial potassium channels: regulated by ATP (mitoK(ATP)) and of big conductance activated by Ca2+ (mitoBK(Ca)), which were described in inner mitochondrial membrane, play a key role in the protection of heart muscle against ischemia. In this review the last date concerning the mitochondrial ion channels as well as they function in cell metabolism have been presented.

Adenosine Triphosphate↗
PubMed2005

[Lipoic acid: characteristics and therapeutic application].

Lipoic acid (LA) and its reduced form dihydrolipoic acid (DHLA, are present in all prokaryotic and eukaryotic cells. Lipoic acid was once considered a vitamin, but now it is commonly accepted that it can be synthesized de novo in human cells. LA has long been known as a coenzyme of multienzymatic complexes catalyzing the decarboxylation of alpha-ketoacids, but the present investigations are focused on its antioxidative properties. Both LA and DHLA have proved to be potent free radicals scavengers and metal chelators. They are also responsible for the regeneration of active forms of other cellular antioxidants, including vitamins C and E. Moreover, lipoic acid is involved in the regulation of carbohydrate and lipid metabolism. LA is easily absorbed from the gastrointestinal tract, is able to cross the blood-brain barrier, and does not exhibit any serious side effects. All these features make lipoic acid a very promising drug. Nowadays, this compound is used in the treatment of diabetic neuropathy, fungi, and metal poisoning, as well as in liver disorders. The application of lipoic acid in treating other diseases, including hypertension and autoimmunological disorders, needs careful evaluation.

Animals↗