Total synthesis of antibiotics GE2270A and GE2270T.
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Anti-Bacterial Agents↗
Biomedical subjects
Dong Bo Li
Publications and source records attributed to Dong Bo Li.
An improved solid-phase methodology for the synthesis of putative hexa- and heptapeptide intermediates in vancomycin biosynthesis.
The biosynthesis of the vancomycin aglycone involves three oxidative phenol coupling reactions, each catalyzed by a discrete cytochrome P450-like enzyme. Studies on the mechanism and specificity of the enzyme (called OxyB) catalyzing the first coupling, require access to suitable linear peptide precursors, each conjugated as a thioester to a peptide carrier domain of the vancomycin non-ribosomal peptide synthetase. An efficient route to representative free linear peptides is described here. The method makes use of Alloc-chemistry during solid-phase assembly of the peptide backbone, but importantly and in contrast to earlier efforts, largely avoids the use of amino acid side chain protecting groups. In this way, the target linear peptides can be released directly from the solid support under very mild conditions.
Nuclear Magnetic Resonance, Biomolecular↗
An oxidative phenol coupling reaction catalyzed by oxyB, a cytochrome P450 from the vancomycin-producing microorganism.
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Actinobacteria↗
Halogen-halogen interactions in halomethanes.
We report the study of the electronic structure of CHFI(2), CHBrI(2), CHBr(2)I, CHClI(2), and CHCl(2)I using VUV photoelectron spectroscopy (UPS). The lone pair orbital interactions are discussed on the basis of experimental results and comparisons with other halomethanes.
Journal Article↗