Biomedical subjects

Dong-Mei Huang

Publications and source records attributed to Dong-Mei Huang.

3 recordsLinked to original sources

PubMed2006

Density function theory study of CO adsorption on Fe3O4(111) surface.

Density functional theory calculations have been carried out for CO adsorption on the Fe(oct2)- and Fe(tet1)-terminated Fe(3)O(4)(111) surfaces, which are considered as active catalysts in water-gas shift reaction. It is found that the on-top configurations are most stable on these two surfaces. Some bridge configurations are also stable in which the new C-O bond formed between the surface O atom and the C atom of CO. The adsorption on the Fe(oct2)-terminated surface is more stable than on the Fe(tet1)-terminated surface. The density of state reveals the binding mechanism of CO adsorption on the two surfaces. Our calculations have also shown that the absorbed CO can migrate from the on-top site to the bridge site or 3-fold site. The oxidation of CO via surface oxygen atoms is feasible, which is in good agreement with experimental results.

Adsorption↗

PubMed2005

Effect of a single dose of mifepristone on expression of pinopodes in endometrial surface of mice.

AIM: To investigate the effect of mifepristone (RU486) as a single dose on pinopodes expression in the endometrial surface of mice at the time of implantation. METHODS: Pregnant mice in the treated four groups received mifepristone subcutaneously (0.1 mg) between 07:00 and 08:00 AM on Pd (day of pregnancy)1, Pd2, Pd3, and Pd4. Pregnant mice in the non-treated group were used as controls. The uterine horns were collected randomly from two mice in each group between 21:30 and 22:00 PM on Pd4, and from another two mice of the same group between 09:30 and 10:00 AM on Pd5. The specimens were examined by scanning electron microscopy for the detection of pinopodes. RESULTS: When mifepristone was given on Pd1, developing and fully developed pinopodes were observed, but the expression was markedly reduced compared to the control group. When mifepristone was administered on Pd2, only a few developing pinopodes were present. When mifepristone was administered on Pd3, developing pinopodes were observed. When mifepristone was administered on Pd4, different development stage pinopodes were present in specimens collected between 21:30 and 22:00 PM on Pd4, but no pinopodes was observed in specimens taken between 09:30 and 10:00 AM on Pd5. CONCLUSION: These findings suggest that administration of a single dose of RU486 subcutaneously on Pd1, Pd2, Pd3, and Pd4 might play a role in inhibiting development and maturation of endometrium, hence affecting embryo implantation in mice.

Animals↗

PubMed2003

[Insulin signal transduction disorder and development of insulin resistance].

Insulin action is initiated through the binding to its cell-surface receptor, stiring up a series of signal transduction and eventually reach various effectors which produce various physiological effects. Insulin signal transduction is crucial to insulin action. Impairment of insulin signal transduction results in attenuation of insulin action and finally leads to insulin resistance. This article reviewed the function of insulin signal transduction disorder in the development of insulin resistance.

Animals↗