Biomedical subjects

Donghyung Lee

Publications and source records attributed to Donghyung Lee.

4 recordsLinked to original sources

PubMed2005

Attention Deficit Hyperactivity Disorder: manifestation in adulthood.

The purpose of the current study was to investigate the manifestation of ADHD in adults using a combination of structured clinical interview, behavioral self-report, and a range of neuropsychological measures. Symptom criteria that are endorsed by adults with ADHD as compared to non-diagnosed adults and an adult sample with other clinical disorders tend to reflect problems with follow-through, forgetting, organization, and losing things. Notably, adults in the No Diagnosis group endorsed a higher frequency of symptoms than base rates reported elsewhere. Related to sense of time, adults with ADHD endorsed problems with meeting deadlines, not completing tasks, not planning ahead, and having a poorer sense of time significantly more frequently than adults in either the No-Diagnosis or Other Clinical Disorder group. Results highlighted the need for further research specific to the manifestation of ADHD in adulthood and the development of diagnostic criteria that take into account the differences in development as well as age-related differences in contextual demands.

Adolescent↗

PubMed2005

Test review: Delis-Kaplan executive function system.

The Delis-Kaplan Executive Function System (D-KEFS; Delis, Kaplan, & Kramer, 2001) represents the first set of executive tests co-normed on a large and representative national sample designed exclusively for the assessment of executive functions including flexibility of thinking, inhibition, problem solving, planning, impulse control, concept formation, abstract thinking, and creativity. The D-KEFS, composed of nine stand alone tests that can be individually or group administered, provides a standardized assessment of executive functions in children and adults between the ages of 8 and 89. Utilizing a "cognitive-process approach," the D-KEFS tests allow examiners to systematically generate and evaluate relevant clinical hypotheses on executive functioning of a given examinee by comparing and contrasting performance on multiple testing conditions and using contrast measure scores and error analyses. A review of the administration, scoring and interpretation, test construction, standardization, and technical adequacy indicate that the D-KEFS holds much promise not only as a clinical instrument, but also as a research tool for increasing knowledge of the frontal-lobe functions.

Humans↗

PubMed2004

Wisconsin Card Sorting Test with children: a meta-analytic study of sensitivity and specificity.

More and more frequently the presence of executive function deficits appears in the research literature in conjunction with disabilities that affect children. Research has been most directed at the extent to which executive function deficits may be implicated in specific disorders such as attention deficit hyperactivity disorder (ADHD); however, deficits in executive function have been found to be typical of developmental disorders in general. The focus of this paper is to examine the extent to which one frequently used measure of executive function, the Wisconsin Card Sorting Test (WCST), demonstrates sensitivity and specificity for the identification of those executive function deficits associated with ADHD as well as its use with other developmental disorders through meta-analytic methods. Evidence of sensitivity of the WCST to dysfunction of the central nervous system is reviewed. Effect sizes calculated for all studies compared groups of children on differing variables of the WCST. The results of this meta-analysis suggest that across all of the studies, individuals with ADHD fairly consistently exhibit poorer performance as compared to individuals without clinical diagnoses on the WCST as measured by Percent Correct, Number of Categories, Total Errors, and Perseverative Errors. Notably, other various clinical groups performed more poorly than the ADHD groups in a number of studies. Thus, while impaired performance on the WCST may be indicative of an underlying neurological disorder, most likely related to frontal lobe function, poor performance is not sufficient for a diagnosis of ADHD. Implications for further research are presented.

Attention Deficit Disorder with Hyperactivity↗

PubMed2003

Controlling diaza-Cope rearrangement reactions with resonance-assisted hydrogen bonds.

NMR studies reveal that the equilibrium between 1 and 2 lies essentially toward 1 to the left without any detectable amount of 2. DFT computation shows that the value of K1 is about 1.4 x 10-5, and X-ray crystal structures show that the resonance-assisted hydrogen bond (RAHB) in 1 (1.66 A) is shorter than the regular hydrogen bond in 2 (1.75 A). The enormous selectivity can be explained in terms of the strength of the RAHBs in 1 compared to that of the regular hydrogen bonds in 2.

Journal Article↗