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Biomedical subjects

Dorota Górecka

Publications and source records attributed to Dorota Górecka.

5 recordsLinked to original sources
PubMed2003

Diagnosis of airflow limitation combined with smoking cessation advice increases stop-smoking rate.

OBJECTIVES: To assess how the diagnosis of airflow limitation (AL) combined with advice to stop smoking in middle-aged smokers influence the smoking cessation rate and to identify predictors of successful outcome. DESIGN: Prospective, single-center, comparative study of the effects of smoking intervention in smokers with diagnosed AL and in smokers with normal lung function (NLF). SETTING: University hospital, out-patient clinic. PARTICIPANTS: Of 659 smokers participating in a population spirometric screening for COPD combined with smoking cessation advice, 558 (AL, 297 smokers; NLF, 261 smokers) were invited for a follow-up after 1 year. INTERVENTION: At follow-up, spirometry was repeated and smoking status was assessed. Nonsmoking status was validated with carbon monoxide measurements in exhaled air. Patients who did not come for the follow-up visit were considered to be smokers. RESULTS: Of 558 smokers invited, 368 (66%) presented for the follow-up visit. All had tried to reduce their smoking habit. The number of cigarettes smoked per day (cpd) at 1 year was - 5.2 (p < 0.01) in patients with AL and - 2.7 (not significant [NS]) in those with NLF. The 1-year cessation rate in smokers with AL was 10.1% vs 8.4% in smokers with NLF (NS). After stratifying the patients according to AL severity, the highest cessation rate was observed in smokers with moderate and severe AL (16.5%) compared to smokers with mild AL (6.4%; p < 0.001) and smokers with NLF (8.4%; p < 0.05). In a univariate analysis, the cessation of smoking was correlated with older age (p < 0.001), later age when starting smoking (p < 0.005), lower tobacco exposure (in pack-years; p < 0.01), fewer cpd (p < 0.001), and lower lung function (p < 0.05). No interaction effect was observed for any of the studied variables using two-way analysis of variance. In a stepwise logistic regression analysis, age (p < 0.001), tobacco exposure (in pack-years; p < 0.001), and FEV(1) percent predicted (p < 0.01) proved to be significant predictors of success in stopping smoking. CONCLUSION: All smokers, irrespective of their lung function, tried to modify their habit as the result of screening for COPD combined with smoking cessation advice. The diagnosis of AL motivated smokers to attempt to quit smoking. Older age, lower tobacco exposure, and lower lung function were the predictors of success in quitting smoking.

Age Factors↗
PubMed2002

[Early detection of COPD in smokers from Warsaw using spirometric screening].

COPD is the fourth leading cause of death in Poland. The disease is diagnosed not early enough. The aim of the study was to establish prevalence of COPD in smokers, inhabitants of Warsaw. Therefore, using local mass media, smokers with at least 10 pack-years history of smoking, over 40 years of age, were invited for a free spirometry. The spirometries were performed during 33 weekends. 3340 subjects (51.8% M and 48.2% F) mean age 57 +/- 13.2 years were examined. Most of them were current smokers (57.8%) or ex-smokers (27%) with a history of 31.9 +/- 18.8 packyears, the remaining subjects (15.2%) declared themselves as a life non-smokers. From all screened 1520 (45.6%) presented airflow limitation (AL). Following ERS recommendations, AL was classified as mild in 27.7%, moderate in 11.1% and severe in 6.8% subjects. One third of examined declared morning cough (36.9%) or sputum production (34.8%), or both symptoms (26.7%). Morning cough (p < 0.05) or cough together with sputum production (p < 0.01) were related to result of spirometry. Subjects aged > or = 40 years with a history of > or = 10 packyears had AL diagnosed in 50.1%, in contrast to younger than 40 years and smoking < 10 packyears in whom AL was detected in 14.3%. In life non-smokers AL was diagnosed in 35.9%. The majority of non-smokers were females (70%), 7.5% declared history of bronchial asthma. The great efficacy of AL detection in targeted population (50%) should be an incentive to perform routine spirometric examination in smokers aged 40+ with a history of 10+ packyears of smoking.

Adult↗
PubMed2002

[Organizing pneumonia--diagnostic and therapeutic problems].

Organizing pneumonia (OP) is a well histopathologically defined disease, which can be induced by many factors--infections, drugs, connective tissue diseases etc. In many cases a rapidly progressive course is observed with clinical picture of pneumonia. We report a case of organizing pneumonia with an acute onset and rapid deterioration in 58-year-old women. After unsuccessful treatment with antibiotics, prompt biopsy of the lung (videothoracoscopy) helped to establish the diagnosis. A rapid improvement after corticoid therapy was observed. Low dose corticoid treatment is continued. Patients remains well 20 months after onset of symptoms.

Anti-Inflammatory Agents↗
PubMed2002

[Primary ciliary dyskinesia--Kartagener's syndrome and fertile male].

Primary ciliary dyskinesia (PCD) is a rare genetic disease, in which a number of human organs are involved: upper and lower respiratory tract, spermatozoa in males and fallopian tube in females. In minority of cases PCD presents as Kartagener's syndrome (KS): sinusitis, bronchiectasis and inversion of internal organs. We report a case of Kartagener's syndrome in 43-year-old fertile male. After clinical and radiological examination and biopsy of the bronchial mucosa diagnosis of KS was established. The problem of fertility in KS males is discussed.

Adult↗