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Biomedical subjects

Douglas J McDonald

Publications and source records attributed to Douglas J McDonald.

7 recordsLinked to original sources
PubMed2006

Osteoblastomatosis of bone. A benign, multifocal osteoblastic lesion, distinct from osteoid osteoma and osteoblastoma, radiologically simulating a vascular tumor.

Two adult patients are described with multifocal osteolytic lesions radiologically simulating a vascular tumor. One patient had multiple bones involved. Histologically, the individual lesions had the features of the nidus of osteoid osteoma/osteoblastoma. A review of the English language medical literature yielded only one other reported case with similar features. The process is designated as osteoblastomatosis to indicate its bone-forming character, prominent osteoblast proliferation, and multiplicity. The cases are distinguished from multifocal/multicentric osteoid osteoma and osteoblastoma, and from benign and malignant vascular tumors.

Adult↗
PubMed2006

Treatment of periprosthetic femoral shaft nonunion.

The purpose of this study is to review the contemporary treatment of periprosthetic femoral shaft nonunions. Thirteen periprosthetic femoral shaft nonunions in 13 patients were reviewed retrospectively. The average follow-up was 48.3 months. Five patients were treated with open reduction and internal fixation, 3 patients were treated with open reduction and internal fixation and prosthesis revision, and 5 were treated with partial femoral replacing prosthesis. Functional outcomes were assessed using a modified Harris hip score. Twelve of 13 nonunions were treated successfully as defined by either radiographic union or a well-functioning prosthesis. Four major complications, 2 requiring reoperation, were noted. These included persistent nonunion, dislocation, and new periprosthetic fracture. Successful treatment of periprosthetic femoral shaft nonunion yielded excellent pain relief, improved function, and patient satisfaction. However, complication and reoperation rates remain high.

Aged↗
PubMed2006

Diffuse-type tenosynovial giant cell tumor in association with neurofibromatosis type 1-Noonan syndrome: possibly more than a chance relationship.

A case of diffuse-type tenosynovial giant cell tumor arising in the left upper extremity is reported in a 23-year-old man with neurofibromatosis type 1 (NF1)-Noonan syndrome. The predominately mononuclear cellular proliferation with psammomatous calcifications had the immunohistochemical and ultrastructural features of a fibrohistiocytic neoplasm. This uncommon type of soft tissue neoplasm occurring in this unique clinical setting served to open an inquiry into the subject of non-neurogenic tumors in association with NF1 and Noonan syndrome, both manifested in our patient. Nonossifying fibroma of bone as a presumptive fibrohistiocytic tumor is an uncommon but well-documented manifestation in NF1, whereas in Noonan-like syndrome, both giant cell granuloma and pigmented villonodular synovitis are recognized as associated lesions with histologic and immunophenotypic similarities with the diffuse-type tenosynovial giant cell tumor.

Adult↗
PubMed2006

Case reports: Osteosarcoma without radiographic evidence of tumor.

There have been cases of osteosarcoma in which conventional radiographs showed only minimal abnormalities. However, the absence of any evidence of tumor has not been reported. We report a unique case of osteosarcoma in a patient who originally presented with a fracture incurred after minimal trauma. The patient had no radiographic evidence of the tumor even after retrospective analysis.

Accidental Falls↗
PubMed2003

Fibrous dysplasia with cartilaginous differentiation ("fibrocartilaginous dysplasia"): a review, with an illustrative case followed for 18 years.

A 21-year-old man with an 18-year history of progressive, and deforming, monomelic fibrous dysplasia with massive cartilaginous differentiation (fibrocartilaginous dysplasia) is described. A review is made of all prior reported examples of this entity in the English language medical literature. The radiologic and histologic differential diagnoses are described, distinguishing the lesion from chondrosarcoma and from fibrocartilaginous mesenchymoma.

Adult↗
PubMed2002

Metal-associated angiosarcoma of bone: report of two cases and review of the literature.

Angiosarcoma is an extremely rare bone tumor. The authors report two cases of patients with angiosarcoma that developed adjacent to a stainless steel plate used for fixation of a femur fracture. In both patients, the interval between fracture treatment and the development of the neoplasm was more than 40 years. A review of the literature found 36 previously reported cases of malignancy arising adjacent to an orthopaedic implant. Despite any evidence directly linking these implants to the development of cancer, continued vigilance is warranted.

Aged↗