Biomedical subjects

Duncan N French

Publications and source records attributed to Duncan N French.

28 records · Page 2Linked to original sources

PubMed2003

Increasing fluid milk favorably affects bone mineral density responses to resistance training in adolescent boys.

This study examined the effects of increasing milk on bone and body composition responses to resistance training in adolescents. Twenty-eight boys (13 to 17 years of age) were randomly assigned to consume, in addition to their habitual diet, 3 servings/day of 1% fluid milk (n=14) or juice not fortified with calcium (n=14) while engaged in a 12-week resistance-training program. For all subjects combined, there were significant (P<or=.05) changes in height (+0.5%), sigmaseven skin folds (-7.7%), body mass (+2.6%), lean body mass (+5.1%), fat mass (-9.3%), whole-body bone mineral content (+3.6%), bone mineral density (+1.8%), and maximal strength in the squat (+43%) and bench press (+23%). Compared with juice, the milk group had a significantly greater increase in bone mineral density (0.014 vs 0.028 g/cm(2)). Increasing intake of milk in physically active adolescent boys may enhance bone health.

Absorptiometry, Photon↗

PubMed2003

The effects of amino acid supplementation on muscular performance during resistance training overreaching.

The purpose of this study was to examine the effects of amino acid supplementation on muscular strength, power, and high-intensity endurance during short-term resistance training overreaching. Seventeen resistance-trained men were randomly assigned to either an amino acid (AA) or placebo (P) group and underwent 4 weeks of total-body resistance training consisting of two 2-week phases of overreaching (phase 1: 3 x 8-12 repetitions maximum [RM], 8 exercises; phase 2: 5 x 3-5 RM, 5 exercises). Muscle strength, power, and high-intensity endurance were determined before (T1) and at the end of each training week (T2-T5). One repetition maximum squat and bench press decreased at T2 in P (5.2 and 3.4 kg, respectively) but not in AA, and significant increases in 1 RM squat and bench press were observed at T3-T5 in both groups. A decrease in the ballistic bench press peak power was observed at T3 in P but not AA. The fatigue index during the 20-repetition jump squat assessment did not change in the P group at T3 and T5 (fatigue index = 18.6 and 18.3%, respectively) whereas a trend for reduction was observed in the AA group (p = 0.06) at T3 (12.8%) but not T5 (15.2%; p = 0.12). These results indicate that the initial impact of high-volume resistance training overreaching reduces muscle strength and power, and it appears that these reductions are attenuated with amino acid supplementation. In addition, an initial high-volume, moderate-intensity phase of overreaching followed by a higher intensity, moderate-volume phase appears to be very effective for enhancing muscle strength in resistance-trained men.

Adolescent↗

PubMed2003

The effects of L-carnitine L-tartrate supplementation on hormonal responses to resistance exercise and recovery.

The purpose of this investigation was to examine the influence of L-carnitine L-tartrate (LCLT) supplementation using a balanced, cross-over, placebo-controlled research design on the anabolic hormone response (i.e., testosterone [T], insulin-like growth factor-I, insulin-like growth factor-binding protein-3 [IGFBP-3], and immunofunctional and immunoreactive growth hormone [GHif and GHir]) to acute resistance exercise. Ten healthy, recreationally weight-trained men (mean +/- SD age 23.7 +/- 2.3 years, weight 78.7 +/- 8.5 kg, and height 179.2 +/- 4.6 cm) volunteered and were matched, and after 3 weeks of supplementation (2 g LCLT per day), fasting morning blood samples were obtained on six consecutive days (D1-D6). Subjects performed a squat protocol (5 sets of 15-20 repetitions) on D2. During the squat protocol, blood samples were obtained before exercise and 0, 15, 30, 120, and 180 minutes postexercise. After a 1-week washout period, subjects consumed the other supplement for a 3-week period, and the same experimental protocol was repeated using the exact same procedures. Expected exercise-induced increases in all of the hormones were observed for GHir, GHif, IGFBP-3, and T. Over the recovery period, LCLT reduced the amount of exercise-induced muscle tissue damage, which was assessed via magnetic resonance imaging scans of the thigh. LCLT supplementation significantly (p < 0.05) increased IGFBP-3 concentrations prior to and at 30, 120, and 180 minutes after acute exercise. No other direct effects of LCLT supplementation were observed on the absolute concentrations of the hormones examined, but with more undamaged tissue, a greater number of intact receptors would be available for hormonal interactions. These data support the use of LCLT as a recovery supplement for hypoxic exercise and lend further insights into the hormonal mechanisms that may help to mediate quicker recovery.

Administration, Oral↗

PubMed2003

Changes in dynamic exercise performance following a sequence of preconditioning isometric muscle actions.

Complex training is the method of coupling heavy and light loads into an organized sequence with the aim of facilitating postactivation potentiation. Anecdotal evidence has supported the use of complex training sequences, but scientific studies investigating the effects of sequencing isometric loads with dynamic muscle actions have been limited. The purpose of this study was to examine the effects of a preconditioning sequence of maximal isometric knee extensions on performance standards in selected dynamic whole-body exercise. Fourteen track and field athletes (23 +/- 5.7 years; 71.53 +/- 6.93 kg; 172.6 +/- 5.8 cm) were randomly assessed in selected whole-body exercises (drop and countermovement jumps, 5-second cycle sprint, knee extension) following a sequence of maximal voluntary isometric contractions (MVC; 3 repetitions of 3 seconds or 3 repetitions of 5 seconds) or in the absence of prior loading (control). Electromyographic (EMG) assessments of muscle activity were also made during the knee extension assessment. Significant (p < or = 0.05) increases in jump height (5.03%), maximal force (4.94%), and acceleration impulse (9.49%) were observed in the drop jump following 3 repetitions of 3-second MVC only. Knee extension maximal torque was also significantly increased (6.12%) following the 3-second MVC. No significant changes in countermovement jump or cycle sprint measures were observed for any of the experimental conditions. Though adaptations were found, changes in EMG activity were not significantly different for any of the experimental conditions. These data indicate that performing a sequence of repeated maximal isometric knee extensions (3 repetitions of 3 seconds) prior to selected dynamic exercise (< or =0.25 seconds) may have favorable effects on performance beyond standards achieved without prior heavy loading.

Adult↗

PubMed2003

Physiological and functional effects of acute low-frequency hand-arm vibration.

The effects of low frequency of vibration have not been widely studied in the scientific literature, yet humans are exposed to such environmental stress everyday. The purpose of this investigation was to examine the physiological responses to low-frequency upper-body limb vibration. Fourteen healthy men were exposed to 1 hour of bilateral hand-arm vibration and control (no vibration) conditions in a counter-balanced, cross-over design separated by 2 days. Subjects gripped handles that were coupled to a vibrating device, which oscillated in an anterior to posterior direction at a constant frequency of 7.5 Hz and a displacement of 0.38 cm. A series of tests were performed prior to and following the vibration to assess cardiovascular response, visual acuity, tremor of the hand and fingers, grip strength, anticipation response, limb girths, and a movement repositioning task. There were significantly (p < or = 0.05) more visual errors postvibration compared with postcontrol on a standardized vision chart. Tremor was significantly reduced during the vibration compared with the control condition. There were no significant changes in grip strength. Mean anticipation response time was significantly increased during the control condition (+3.3%) but not after vibration (+1.0%). There was a significant improvement in the movement repositioning task after vibration compared with control. Heart rates during the vibration protocol were not significantly higher than the control condition. No significant increases in limb size representative of swelling were observed. These data indicate that exposure to 1 hour of low-frequency hand-arm vibration has only minor effects on physiological function.

Adult↗

PubMed2002

Effect of alkalosis on plasma epinephrine responses to high intensity cycle exercise in humans.

The purpose of this study was to determine the effects of alkalosis on epinephrine concentrations in response to a 90 s maximal exercise test. A group of ten healthy men ingested either a bicarbonate (BS) supplement (0.3 g x kg(-1) of body mass of sodium bicarbonate) or placebo mixture (P) prior to performing a 90 s maximal cycle ergometer test. An indwelling Teflon cannula was placed in the antecubital vein and blood samples were drawn at three times at rest separated by 10 min, immediately following the protocol, and at 2.5, 5, and 10 min post exercise to determine plasma epinephrine concentrations. Sodium bicarbonate ingestion significantly ( P<0.05) induced alkalosis both at rest [mean (SD) pH=7.42 (0.02) BS, 7.38 (0.02) P] and after the exercise protocol [pH=7.16 (0.02) BS, 7.12 (0.02) P]. Plasma epinephrine concentrations were not significantly different immediately post exercise between the two conditions [4.2 (0.6) compared to 4.2 (0.7) pmol x ml(-1) in BS and P, respectively]. Work performed and power output attained were not significantly different between the two treatment conditions [mean power=258.7 (35.1) W BS, 260.3 (35.4) W P; peak power=534.7 (61.6) W BS, 535.7 (54.4) W P]. The primary finding of this investigation was that orally-induced alkalosis does not significantly affect plasma epinephrine concentrations or performance following 90 s of maximal cycle exercise in untrained men.

Acid-Base Equilibrium↗

PubMed2002

Performance, biochemical, and endocrine changes during a competitive football game.

PURPOSE: This study represents the first time that anaerobic power performance was examined during an actual intercollegiate American football game. In addition, biochemical and endocrine responses also were examined to assess the physiological stress imposed by this competitive contest. METHODS: Twenty-one members of a NCAA Division III football team were divided into two groups. Group one (ST) were starters (N = 11). The second group (RS) consisted of red-shirt players (N = 10). Blood samples were obtained 24 h (Pre1) and 2.5 h (Pre2) before the game and within 15 min of game conclusion (IP). Anaerobic power measures were recorded approximately 10 min before kickoff (pre) and following the first (Q1), second (Q2), third (Q3), and fourth (Q4) quarters. RESULTS: Peak force (PF) and power (PP) in both squat and countermovement jumps decreased (P < 0.05) from pre to Q2 in both ST and RS; however, all variables returned to baseline levels by Q4. When averaged across trials, PF and PP in both jumps were greater (P < 0.05) in ST than RS. No significant changes in testosterone concentrations with respect to time or between groups were seen. Cortisol concentrations were significantly higher for ST at IP than RS. No significant changes in creatine kinase, alanine aminotransferase, urea, or uric acid were observed in either group from Pre2 to IP. In addition, no between group differences were seen in these variables. Myoglobin and aspartate aminotransferase significantly increased from Pre2 to IP in ST, and a significant difference in myoglobin concentrations was seen between the groups at IP. CONCLUSIONS: Performance, biochemical, and endocrine changes in these NCAA Division III football players reflected the stress and muscle damage that occurs as a result of a competitive American football game.

Adult↗

PubMed2002

Resistance training for health and performance.

Resistance training is recommended by national health organizations for incorporation into a comprehensive fitness program that includes aerobic and flexibility exercise. Its potential benefits on health and performance are numerous; it has been shown to reduce body fat, increase basal metabolic rate, decrease blood pressure and the cardiovascular demands to exercise, improve blood lipid profiles, glucose tolerance, and insulin sensitivity, increase muscle and connective tissue cross-sectional area, improve functional capacity, and relieve low back pain. Many improvements in physical function and athletic performance are associated with the increases in muscle strength, power, endurance, and hypertrophy observed during resistance training. The key element to effective resistance training is supervision by a qualified professional and the proper prescription of the program variables. Proper program design, ie, that which uses progressive overload, variation, and specificity, is essential to maximize the benefits associated with resistance training.

Exercise↗

PubMed2002

The effects of a 10-kilometer run on muscle strength and power.

Recovery of maximal force and power following a 10-km race has not been widely studied in the scientific literature. Ten healthy men who were experienced distance runners participated in this investigation. Data were collected prerace, immediate postrace, and 48 hours postrace to examine the effect of a 10-km race on muscle force production in the lower body. Maximal peak torque was measured via an isokinetic dynamometer at 30 degrees, 180 degrees, and 300 degrees.s-1. A significant (p <or= 0.05) reduction in peak torque for knee flexion was observed at 30 degrees.s-1 immediately postrace. Average power of the knee flexors were significantly decreased immediately postrace. Total work (J) flexion performed over the last 17 repetitions of the 50-repetition test were significantly reduced from baseline values during both the immediate and 48-hour postrace tests. Significant reductions in peak vertical jump force remained reduced 48 hours postrace testing. No changes were observed for jump power after the race. These data indicate that only the hamstring muscle group was not fully recovered to perform the 50-repetition test and that force production in the vertical jump test was compromised 48 hours after a 10-km race. Nevertheless, it appears that strength and power capabilities of the 10-km runner are for the most part restored 48 hours after an all-out 10-km race effort. From a practical perspective, it appears that a minimum of 48 hours should be utilized between multiple trials in 10-km races at track and field meets.

Adolescent↗

PubMed2002

Detraining produces minimal changes in physical performance and hormonal variables in recreationally strength-trained men.

The object of this study was to examine changes in muscular strength, power, and resting hormonal concentrations during 6 weeks of detraining (DTR) in recreationally strength-trained men. Each subject was randomly assigned to either a DTR (n = 9) or resistance training (RT; n = 7) group after being matched for strength, body size, and training experience. Muscular strength and power testing, anthropometry, and blood sampling were performed before the experimental period (T1), after 3 weeks (T2), and after the 6-week experimental period (T3). One-repetition maximum (1RM) shoulder and bench press increased in RT at T3 (p </= 0.05), whereas no significant changes were observed in DTR. Peak power output and mean power output significantly decreased (9 and 10%) in DTR at T2. Peak torque of the elbow flexors at 90 degrees did not change in the RT group but did significantly decrease by 11.9% at T3 compared with T1 in the DTR group. Vertical jump height increased in RT at T2 but did not change in DTR. Neither group displayed any changes in 1RM squat, body mass, percent body fat, or resting concentrations of growth hormone, follicle-stimulating hormone, luteinizing hormone, sex hormone-binding globulin, testosterone, cortisol, or adrenocorticotropin. These data demonstrate that 6 weeks of resistance DTR in recreationally trained men affects power more than it does strength without any accompanying changes in resting hormonal concentrations. For the recreational weight trainer, losses in strength over 6 weeks are less of a concern compared with anaerobic power and upper arm isometric force production. Anaerobic power exercise with a high metabolic component coming from glycolysis might be of importance for reducing the impact of DTR on Wingate power performances. A minimal maintenance training program is recommended for the recreational lifter to offset any reductions in performance.

Adult↗