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Biomedical subjects

E A Abayomi

Publications and source records attributed to E A Abayomi.

6 recordsLinked to original sources
PubMed2000

Aids is now the commonest clinical condition associated with multilineage blood cytopenia in a central referral hospital in Zimbabwe.

OBJECTIVE: To describe the clinical features and diagnosis of patients hospitalised and found to have multilineage peripheral blood cytopenias. DESIGN: Prospective cross sectional study. SETTING: Parirenyatwa Hospital, a central referral hospital in Harare, Zimbabwe. SUBJECTS: 231 consecutive patients whose blood parameters revealed bi- or trilinneage cytopenia during a five month period in 1996. MAIN OUTCOME MEASURES: 1. Blood cytopenia was described as: (a) Haemoglobin concentration = or < 100 g/L (b) Total leucocyte count = or < 3.5 x 10(9)/L (c) Platelet count = or < 100 x 10(9)/L 2. Other clinical and diagnostic features. RESULTS: The highest percentage of multilineage blood cytopenia was in the age bracket 30 to 44 years and the male to female ratio was 1.4:1. Pancytopenia was found in 32.5% of patients, while bilineage cytopenia occurred in 67.5%. The commonest bilineage pattern was the combination of anaemia and thrombocytopenia occurring in 46.3% of all study cases or 68.5% of bilineage cytopenias. Anaemia was the most frequent cytopenia; it was found in 95.2% of all study cases. CONCLUSION: The commonest condition with which multilineage blood cytopenia was associated was AIDS which was diagnosed in 25.1% of the study cases.

Acquired Immunodeficiency Syndrome↗
PubMed1999

Use of packed red cells in a major hospital in Harare, Zimbabwe.

OBJECTIVES: To document the current pattern of packed red cell (PC) usage and the crossmatch to transfusion ratio (C/T ratio) in a major city teaching hospital in Harare, Zimbabwe. DESIGN: Restropective, (audit). SETTING: Harare Central Hospital, a 1,200 bed multidisciplinary hospital located in Harare, Zimbabwe. MAIN OUTCOME MEASURES: Amount of PC ordered and proportion collected for the year 1995. Quantity of PC used by different medical specialties. RESULTS: In 1995 a total of 8,292 PC were collected from Harare Hospital blood bank. This translates to an average PC usage for a 1,200 bed hospital of seven units per hospital bed per year. Only 48.5% of PC crossmatched was collected with a C/T ratio of 2.1:1. Revenue loss of Z$478,434 is estimated to have occurred due to expired units and resource wastage from uncollected crossmatched units. The largest consumer of PC was the Department of Gynaecology, followed by Surgery and Paediatrics. CONCLUSION: Regular auditing of blood usage is recommended to promote the efficient use of PC in accordance with accepted international standards and local guidelines and practice.

Blood Grouping and Crossmatching↗
PubMed1998

Accidental HIV exposure.

This is a case presentation of an accidental contaminated needle stick injury from a patient known to be infected with both Human Immunodeficiency Virus (HIV) and hepatitis B. The patient was managed with prophylactic hepatitis B immune globulin, hepatitis B vaccination and the HIV retroviral drug zidovudine (AZT). At one year after treatment the patient was not infected with HIV or hepatitis B, and there was adequate immunity generated after vaccination for hepatitis B.

Accidents, Occupational↗
PubMed1997

Primary cerebral lymphoma in Zimbabwe: a report of three patients.

Primary central nervous system lymphoma (PCNSL) is steadily increasing. Immunosuppressed individuals are at particular risk. In AIDS patients a clinical diagnosis of PCNSL is made in 0.5 to 8.4%, and a post mortem diagnosis in up to 11% of cases. In spite of the extensive HIV epidemic in parts of Africa, a literature search revealed only one African report of this condition. The reasons for this apparent infrequency are not clear. Possibilities include under diagnosis or early demise of patients due to other AIDS related illnesses of earlier onset. Three patients with primary cerebral lymphoma from Zimbabwe are presented. All were young, with tumours of high grade showing typical features.

Adult↗
PubMed1996

von Willebrand factor in diabetic retinopathy.

OBJECTIVE: To elucidate the qualitative nature of elevated levels of von Willebrand factor (vWF) in diabetic microagiopathy. DESIGN: A randomized controlled study. SETTING: Oxford Health Authority, Oxfordshire, United Kingdom. SUBJECTS: Insulin dependent diabetic patients with established retinopathy, and an age, sex matched control group. MAIN OUTCOME MEASURES: Diabetic retinopathy, a modified enzyme-linked immunosorbent assay (ELISA), used to distinguish between endothelial and plasma type vWF. RESULTS: vWF is higher in patients with diabetic retinopathy mean (217u/dl) compared with normal subjects mean (8/u/dl). vWF in both patient and control are of the plasma type. CONCLUSION: vWF in diabetic retinopathy is raised and of the plasma type, suggesting it is not due to acute vascular endothelial injury.

Case-Control Studies↗