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Biomedical subjects

E A Amin

Publications and source records attributed to E A Amin.

9 recordsLinked to original sources
PubMed1998

Mobile mammography screening: the James Graham Brown Cancer Center three year experience. Implications for public and professional education.

OBJECTIVE: Review the mobile mammography screening experience at the James Graham Brown Cancer Center during a 3 year interval. METHODS: Collect and analyze demographic and outcome data on the screened population. RESULTS: 4,864 women underwent two-view mammograms. One third of the mammograms were performed in women over 50 years of age. 232 mammograms were carried out per cancer detected. The number of mammograms per cancer detected was 2.5 times higher and the number of biopsies per cancer detected was 2.8 times higher in women under 50 years of age. Two thirds of the cancers detected were in the over 50 age group which represents one third of the study population. CONCLUSIONS: In this study, mammographic screening for breast cancer was more cost effective because a higher yield of cancers detected was obtained with fewer mammograms and fewer breast biopsies in women over 50 years of age, compared to women under 50 years. Resolving the question of the cost effectiveness of screening women aged 40 to 49, will require a large randomized prospective trial. In the near term, rather than to dwell on this issue, we would propose that this study suggests the need for greater emphasis in both public and professional education on breast cancer detection directed to women over 50 years of age.

Adult↗
PubMed1992

Comparison of the cost-effectiveness of various therapies for common prostatic disorders.

Diseases of the prostate currently represent a major health problem worldwide. As the age of the male population increases in the future, so will the number of patients suffering from these disorders and the cost for treatment increase. Currently, benign prostatic hyperplasia (BPH) and prostate cancer are common in men over 50 years of age. In men after puberty, prostatic infections (prostatitis) are common. Each condition carries with it controversy regarding the most cost-effective treatment. Treatment for these disorders can include surgical intervention, drug therapy, or no treatment at all. In the United States, surgery is the usual treatment of BPH in men over 65 years of age, but most patients with BPH are asymptomatic and require no intervention. Aside from acute urinary retention or backpressure that compromises renal function, the indications to perform surgery are questionable. While some alpha-adrenergic antagonists are used to temporarily relieve symptoms, many patients with BPH will eventually require surgery. Transurethral resection of the prostate is the surgical treatment of choice in selected patients with BPH, accounting for over 90% of surgery performed in this area. The risk-to-benefit ratio for this procedure is favourable and cost-saving steps can be taken by the physician. Open prostatectomy, both suprapubic and retropubic, is performed to treat large prostates. However, both hospital stay and overall morbidity is higher for open prostatectomy than for transurethral prostatic resection. Radical prostatectomy and radiotherapy are commonly performed to treat patients with cancer of the prostate. For patients with the early stages of the disease, administering no treatment is also acceptable. Each therapeutic method has its advocates, and overall survival rates are similar for all treatments. Radiotherapy, however, is less expensive. We review the magnitude of these diseases, therapies available and relevant cost-effectiveness studies. When this sort of scientific information is not taken into account, the physician's decision of which therapy to choose is sometimes blinded by the prejudices and fears of the patient.

Catheterization↗
PubMed1990

Carcinoma of the prostate simulating primary bladder cancer.

After encountering two patients who were diagnosed as having primary bladder cancer but were ultimately found to have carcinoma of the prostate invading the bladder, a prospective study was undertaken. In five patients with known carcinoma of the prostate invading the bladder, cup biopsies of the bladder lesions were reported as primary bladder cancer in four patients. To prevent this error, immunohistochemical studies are required and discussed in this paper.

Aged↗
PubMed1989

Breast cancer risk: a review of definitions and assessments of risk.

The histopathological and biochemical characteristics of cells and multicellular structure of benign and malignant breast changes have highly significant implications as to the risk of acquiring and dying of breast cancer. Consequently, every breast biopsy merits highly specific histopathological characterization as well as assay for hormone receptors. Certain aspects of a woman's personal and family history may be associated with increased or decreased risk. Clinical application of these variables to the prediction of future outcome requires an understanding of the definitions of risk. These definitions must then be applied appropriately when assessing risk. The definition of risk used must be explicitly stated and consistently used. Provided is a review of the definitions of risk and the risk of acquiring breast cancer according to age, family history, and histopathological characteristics of benign breast biopsies. The highly variable relative risk of dying from breast cancer when diagnosed is also reviewed.

Breast Neoplasms↗
PubMed1988

Blunt urethral injury: results of initial management.

Fourteen men with blunt urethral disruption were treated between 1979-1985. Injuries most commonly resulted from motor-vehicle accidents, as pedestrians or passengers. All patients had additional injuries, including pelvic fracture (13), extremity fractures (10), central nervous system (5), bladder (5) and rectal injury (3); the average injury severity score was 30. Pelvic fracture patterns included ten patients with a crushed pelvis, two with single anterior pelvic ring fractures and one with a double vertical fracture. Blood at the urethral meatus was noted in only five patients, gross hematuria without metal blood in another three, and a displaced prostate on rectal exam was found in 10 cases. All patients had a suprapubic cystostomy for management of the urethral injury. Thirteen of 14 patients survived (93%). The major complication was perineal sepsis. Based on this experience, it is concluded that: 1) the classical findings of urethral injury are not found consistently, 2) certain pelvic fracture patterns, particularly disruption of the anterior pelvic ring, are frequently associated with urethral injury and 3) aggressive and appropriate management of hemorrhage, pelvic fracture and concomitant injuries is important to minimize mortality.

Adult↗
PubMed1987

Bipartite liver. A case report.

Bipartite liver is a rare anomaly that has no apparent phylogenetic significance but does represent a distinct category of congenital liver malformations. Although no associated complications have been known to occur, the potential for internal herniation of the gastrointestinal tract may exist.

Adult↗