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E A Baanders-van Halewijn

Publications and source records attributed to E A Baanders-van Halewijn.

10 recordsLinked to original sources
PubMed1990

[Waist-to-hip ratio in Dutch women and its relationship with self-reported diabetes mellitus, hypertension and cholecystectomy].

The waist-to-hip circumference ratio is recognized as a measure of body fat distribution and as a risk indicator of premature mortality. The distribution of waist-to-hip ratio values in 12,000 Dutch women aged between 40 and 75 years is presented. In addition, the statistical associations between the waist-to-hip ratio and the degree of overweight as well as the prevalence of self-reported diabetes mellitus, hypertension, and cholecystectomy are described. The odds ratios for the prevalence of these disorders increased progressively with increasing waist-to-hip ratio. The age-adjusted odds ratios for women with a waist-to-hip ratio greater than 0.85 in comparison to those with a waist-to-hip ratio less than 0.70 were 4.8, 4.6 and 5.8 for diabetes mellitus, hypertension, and cholecystectomy respectively. The presented data on waist-to-hip ratio can, in combination with Quetelet's index, serve as a guide in the interpretation of measured waist-to-hip ratios in women between 40 and 75 years of age.

Adult↗
PubMed1990

The relationship between fat distribution and some chronic diseases in 11,825 women participating in the DOM-project.

The prevalence of reported chronic diseases was studied in quintiles of waist/hip ratio and Quetelet index in 11,825 women aged 40-73 presenting for mammographic screening in the DOM-project. After adjustment for age and Quetelet index, increased waist/hip ratio was found to be associated with an increased prevalence of diabetes mellitus, hypertension, cholecystectomy and a lower prevalence of varicose veins. No associations were observed between waist/hip ratio and the prevalence of angina pectoris, gout and rheumatism. The odds ratios, adjusted for age and Quetelet index, of the highest versus the lowest quintile of waist/hip ratio were 3.4 (95% CI 1.4-8.3) for diabetes mellitus; 2.2 (95% CI 1.7-2.8) for hypertension; 2.0 (95% CI 1.2-3.4) for cholecystectomy, and 0.81 (95% CI 0.68-0.95) for varicose veins. After adjustment for waist/hip ratio and age, Quetelet index was found to be associated with an increased prevalence of hypertension, cholecystectomy and varicose veins. Quetelet index, however, was not found to be related to diabetes, gout or rheumatism. We conclude that in a representative sample of Dutch women older than 40 years, fat distribution in addition to overweight is related to important chronic diseases.

Adipose Tissue↗
PubMed1990

Fat distribution in relation to age, degree of obesity, smoking habits, parity and estrogen use: a cross-sectional study in 11,825 Dutch women participating in the DOM-project.

Fat distribution (waist/hip ratio) was assessed in a population of 11,825 women, aged 40-73 years, presenting for routine breast cancer screening (the DOM project in Utrecht) in the period 1984 to 1986. Waist/hip ratio increased with increasing Quetelet's index and age. Postmenopausal women did not have higher waist/hip ratios compared to premenopausal women after adjustment for Quetelet's index and age. In pre- and postmenopausal women, waist/hip ratio increased with increasing number of cigarettes smoked per day (while Quetelet's index decreased) and a positive linear relationship was found between parity and waist/hip ratio (also after adjustment for Quetelet's index and age). Age at menarche was strongly inversely related to Quetelet's index but was not related to waist/hip ratio. In postmenopausal women, waist/hip ratio was lower in women who reported to use oestrogens for menopausal complaints in comparison with similar women who did not, but this difference disappeared after adjustment for age and degree of obesity. This study emphasizes the role of some variables that are associated with fat distribution and are potential confounders of risk estimates of abdominal obesity.

Adipose Tissue↗
PubMed1989

Factors influencing waist/hip ratio in randomly selected pre- and post-menopausal women in the dom-project (preliminary results).

In 452 pre- and post-menopausal women aged 41-75, participating in a breast cancer screening programme, we studied the associations between several factors and waist/hip ratio. Differences in waist/hip ratio between pre- and post-menopausal women could be accounted for by age and degree of obesity. In post-menopausal women, waist/hip ratio was positively related to age, independently of the degree of obesity. Post-menopausal women who reported to use oestrogens for menopausal complaints were found to have lower waist/hip values compared to non-users (0.74 vs 0.78 P less than 0.05). Waist/hip ratio was not related to age at menopause, age at menarche or parity. We confirmed that the Quetelet's index is positively related to waist/hip ratio and that, at least before menopause, smokers have higher waist/hip values compared to non-smokers although the mechanisms for such an association remain obscure. Hypertension was associated with abdominal fat distribution in premenopausal but not in post-menopausal women. Diabetes mellitus was associated with abdominal fat distribution in post-menopausal women. These observations in this cross-sectional study suggest that environmental factors (smoking and oestrogen use after menopause) relate to the distribution of fat over the body. The other observations illustrate the importance of stratifying for menopausal status in studies on fat distribution in women.

Adipose Tissue↗
PubMed1985

A case-control study of endometrial cancer within a cohort.

In a population-based prospective study it was shown that weight, height, overweight, total body size, age at first birth, parity and age at menopause are risk factors for the development of endometrial cancer. The finding that the patients had had a higher oestrogen excretion level than the controls some time before diagnosis constitutes the biochemical background for the effect of some of the above variables.

Age Factors↗
PubMed1984

The DOM project for the early detection of breast cancer, Utrecht, The Netherlands.

This report describes the short-term results of a population-based screening programme--the DOM project--during the years 1975-1980. Screening was offered to all women in the city of Utrecht (The Netherlands) and 11 neighbouring areas who were born between 1911 and 1925. Further evaluation will be reported in future publications. The programme was organised by the Department of Epidemiology, Institute of Social Medicine (now renamed The Institute of Public Health and Epidemiology), University of Utrecht, which established a screening centre--The Preventicon--in a new commercial and shopping centre with good public transport facilities. The study population was between 50 and 65 years old at intake, a decision based on results obtained in the H.I.P. study in New York. Women resident in the city of Utrecht (n = 14,697 at intake) were screened four times, with intervals of 12, 18 and 24 months respectively between the first and fourth examinations. Women resident in the other areas (n = 8814) were screened twice with an interval of 18 months. Screening consisted of a clinical examination (inspection, palpation) and xero-mammography. An important role was played by paramedical personnel, who performed the examination and had a degree of responsibility in reading the mammograms. Initially the radiation dose per breast was about 1 rad, but from 1977 onwards this was reduced to 0.4 rad per exposure; for women living in Utrecht (4 screenings) the total dose was less than 5 rad over the 5-year period. Referral policy was based on a set of three types of "signal" to general practitioners (who coordinated specialist services): 1. Recommendation for biopsy; 2. Suggested repeat examination after 6 months; 3. Brief note on palpable abnormalities, considered likely to be benign. In Section II the response of the invited population is analysed. The response rate for the first screening was 72% in the city of Utrecht and 68% in the other areas. Variation in response rates can only be explained to a minor degree by measured demographic and sociological variables, age being the most important determinant. Women were asked to contribute D.fl. 12.50 (approx. US $5) per screening cycle to meet part of the expenses, the rest being paid by public health research funds. A total number of 61,649 examinations was performed in 23,511 women. In Section III the immediate results of screening are presented. An analysis is made of the cancer yield of the 3 signals mentioned above.(ABSTRACT TRUNCATED AT 400 WORDS)

Aged↗
PubMed1984

The Cordon study of weight reduction based on behaviour modification.

A behaviour modification programme for the treatment of obesity was offered to a population of obese women, aged 51-67, being screened for breast cancer. The programme was offered in two forms: (1) A series of ten small group sessions under the guidance of a non-medical leader, with three follow-up meetings after the course (10 S programme). (2). A series of ten mailed lessons with a pre- and post-course interview and three follow-up meetings after the course (10 L programme). The drop-out rate during the course was 12 per cent for the 10 S programme and 37 per cent for the 10 L programme. Follow-up in the 10 S programme revealed an average weight loss of 5.2 kg after 3 months, 4.1 kg after 17 months, and 3.0 kg after 36 months. Comparable figures in the 10 L programme were 3.0 kg, 3.0 kg and 1.6 kg, respectively. Percentile distributions of weight loss after these intervals are presented. Results are compared with those in other obese women in the cancer screening programme who either had no plans for weight reduction or said they had opted for other kinds of intervention. These comparisons clearly favour the behaviour treatment programme, but the picture may have been influenced by a possibly higher motivation of those who followed the course.

Aged↗
PubMed1982

Weight reduction and oestrogen excretion in obese post-menopausal women.

The urinary excretion of oestrone (E1), oestradiol (E2) and oestriol (E2) was measured in 42 obese post-menopausal women before and 6-12 mth after their participation in a weight reduction programme. The method of inducing weight loss was based on modification of eating behaviour without specific changes in dietary composition. Urinary oestrogen, as a ratio to creatinine, were measured by a specific radioimmunoassay after purification of the specific oestrogen fraction. Before weight reduction efforts, there is a significant correlation among E1, weight and the Quetelet-index and between E3 and the Quetelet-index. These correlations have disappeared after weight reduction. There is a significant positive correlation between changes in body-weight and changes in the excretion of E1, E3 and total oestrogens. There was no significant change in the so-called oestrogen ratio (E1 + E2/E3) in relation to change in body weight. With respect to the statistical association between endometrial cancer, breast cancer and overweight, our data give support to the concept that intervention programmes on weight reduction may influence both the incidence and the prognosis of these two diseases.

Body Weight↗