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Biomedical subjects

E A Chekharina

Publications and source records attributed to E A Chekharina.

At least 19 recordsLinked to original sources
PubMed1985

[Colony-forming ability of lymph node fibroblasts in patients with malignant lymphomas].

Determination of the efficiency of fibroblasts' colony-formation in patients with Hodgkin's disease, non-Hodgkin's malignant lymphomas and reactive lymphoid hyperplasia reveals that the colony-forming ability of fibroblasts does not depend on the nature of the pathological process, but depends on the morphofunctional status of the lymphoid tissue. It is found that single determination of fibroblasts colony-formation efficiency cannot be used as a prognostic feature for determination of the further course and outcome of the disease.

Colony-Forming Units Assay↗
PubMed1983

[Feasibility of differential diagnosis of isolated lesions of mediastinal lymph nodes].

Surgical procedures such as mediastinoscopy (101 cases) and parasternal mediastinotomy (6 cases) were used for improvement of diagnosis of lesions in mediastinal organs. As a result of complex examination including histological methods, malignant lymphoma was diagnosed in 12 cases, Boeck's sarcoidosis--75, mediastinal form of lung cancer--8, tuberculosis of mediastinal lymph nodes--6 and other lesions of organs of the mediastinum--in 6 cases.

Adult↗
PubMed1981

[Characteristics of the clinical manifestations of lymphogranulomatosis in children and adults].

Based on a multi-factorial analysis with application of mathematical methods and an electronic computer-32, it was shown that differences in clinical manifestations of lymphogranulomatosis in untreated patients (360 observations) of two age groups--children and adults, concerned the incidence of the disease in males and females, a primary localization of the process and the frequency of separate symptoms, intoxication and histological types. On the contrary, no statistically reliable differences were noted in factors characterizing the malignancy of the process (staging of the disease, the frequency of general symptoms and signs of the biological activity.

Adolescent↗
PubMed1979

[Differential cytological diagnosis of lymph node lesions].

In cytological assay of the material, obtained from 144 patients with different lymph node lesions, the precise diagnosis was established in 119 observations (82.6%), the diagnosis remained unestablished or was erroneous in 25 cases (17.4%). It was found that of primary importance in establishing the differential cytological diagnosis of lymph node lesions are cytomorphological criteria, the role of cytochemical studies is only axilliary.

Biopsy, Needle↗
PubMed1979

[Results of the combined chemotherapy of stage III and IV lymphogranulomatosis].

The authors present an analysis of the results of polychemotherapy: MOPP, CCNU+NMU schedule in 36 patients with generalized lymphogranulomatosis of stage IIIB and IVA,B. An experience with the associated chemotherapy has evidenced the effectiveness of this kind of treatment and the possibility to gain the complete remission approximately in 80% of patients.

Drug Evaluation↗
PubMed1978

[Effect of prednisolone on the nucleic acid content and RNA synthesis in human lymph nodes in systemic diseases].

Studies on quantitative DNA content in lymphnode cells in patients with lymphogranulomatosis and reticulosis indicated that small prednisolon concentrations (0.1 mg/100 mg of cells) may be responsible for a reduced amount of DNA. The study of the quantitative content and turnover rate of total RNA has shown by the labeled uridine-H3 precursor incorporation a considerable decrease of RNA content and the reduce incorporation of the label in total RNA (approximately by 40% on an average).

Clinical Trials as Topic↗
PubMed1978

Effect of chemotherapy on the lymph node and bone marrow cell chromosomes in patients with Hodgkin's disease.

Chromosomal aberrations in bone marrow and lymph node cells have been investigated in 47 patients with lymphogranulomatosis 24--72 hr after administration of a single therapeutic dose of cyclophosphan and natulan. It is shown that the injurious action of cyclophosphan and natulan lasts more than 72 hr. An analysis of the dynamics of various types of chromosomal aberrations testifies that cyclophosphan and natulan affect cellular constituents found in the synthetic or post-synthetic phases of the cell cycle.

Adolescent↗