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Biomedical subjects

E A Covarrubias

Publications and source records attributed to E A Covarrubias.

7 recordsLinked to original sources
PubMed1981

M-mode echocardiographic observations during and after healing of active bacterial endocarditis limited to the mitral valve.

Analysis of 99 M-mode echocardiograms recorded during and up to 144 months after healing of active bacterial endocarditis limited to the mitral valve in 27 patients disclosed the following: (1) Little to no change occurred in the echocardiographic size of the vegetations during the first 6 weeks after diagnosis and institution of appropriate antibiotic therapy unless a major systemic embolus occurred. (2) The echocardiographic size of the vegetations did not determine the amount of cardiac damage or dysfunction produced by the valvular infection. (3) The larger the vegetations by echocardiogram, the greater was the likelihood of a clinical event compatible with a systemic embolus. (4) The gravest prognostic sign yielded by the echocardiogram was evidence of rupture of chordae tendineae. (5) Although a useful adjunct to diagnosis before appropriate antibiotic therapy was instituted, once bacteriologic cure was achieved, the echocardiogram was of limited value in delineating an active from a heated vegetation. (6) The echocardiographic appearance of the vegetations was not determined by the type of infecting bacterium.

Acute Disease↗
PubMed1981

M-mode echocardiographic observations in active bacterial endocarditis limited to the aortic valve.

Analysis of 37 M-mode echocardiograms recorded during the period of active bacterial endocarditis (ABE) involving the aortic valve (AV) in 17 patients disclosed one or more echocardiographic abnormalities involving the aortic valve cusps or their immediate vicinity in 15 (88%), including "shaggy" echoes indicative of vegetations in 12 (71%). Of the 12 patients with echocardiographic evidence of AV vegetation, 11 developed overt congestive heart failure (CHF) and either died or had AV replacement, and seven had clinical events compatible with systemic emboli; of the five patients without echo-demonstrated vegetations, only one had CHF, none had AV replacement, two died, and one had a systemic embolus. In comparison to our previously reported echocardiographic observations in patients with ABE involving either the mitral (29 patients) or tricuspid valve (23 patients), infection involving the AV was far more liable to produce overt CHF and systemic emboli, to necessitate valve replacement, and to cause death during the period of active infection.

Adult↗
PubMed1981

Variant ventricular tachycardia in desipramine toxicity.

We report a case of variant ventricular tachycardia induced by desipramine toxicity. Unusual features of the arrhythmia are repetitive group beating, progressive shortening of the R-R interval, progressive widening of the QRS complex with eventual failure of intraventricular conduction, and changes in direction of the QRS axis. Recognition of variant ventricular tachycardia is important because therapy differs from that of classic ventricular tachycardia.

Adult↗
PubMed1980

Left ventricular function in sickle cell anemia: a noninvasive evaluation.

There is controversy in the medical literature regarding the significance of "sickle cell cardiomyopathy." In an attempt to clarify this, we studied 14 patients with sickle cell anemia (age range 16 to 36 years) using simultaneous echocardiography and phonocardiography. The values of systolic time intervals and echocardiographic indices of left ventricular performance were similar to those reported for normal subjects and those with comparable degrees of anemia. We confirm a previous report of normal left ventricular function at rest in patients with sickle cell anemia and concur with the suggestion that a concomitant heart disease be considered in these patients when cardiac failure supervenes.

Adolescent↗
PubMed1979

Calcific pulmonic stenosis in adulthood: treatment by valve replacement (porcine xenograft) with postoperative hemodynamic evaluation.

Clinical and morphologic features are described in a 56-year-old man in whom severe, isolated pulmonic valve stenosis was treated by valve replacement with a porcine prosthesis. The calcific deposits were located on the ventricular aspect of the pulmonic valve, opposite the location (arterial aspect) of calcific deposits on stenotic aortic valves, and calcific deposits also were present in the tricuspid valve anulus.

Animals↗