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Biomedical subjects

E A Ermakova

Publications and source records attributed to E A Ermakova.

8 recordsLinked to original sources
PubMedDate not supplied

[Brownian dynamics simulation of the association of Bacillus amyloliquefaciens ribonuclease (barnase) and Bacillus intermedius ribonuclease (binase) with barstar].

A comparative study of the association of two ribonucleases, barnase and binase, with the polypeptide inhibitor barstar has been performed by the Brownian dynamics simulation method. It was shown that the method adequately reproduced the dependence of the association rate on pH and ionic strength of solution and the influence of mutations of some ribonuclease amino acids. Two types of energetically favorable complexes of binase-barstar encounter were determined. In the type I complex, the amino acids of binase active center take part in the complex formation. In the second complex, the active center is free. It was supposed that the temporary binding of barstar into complex of type II is competitive relative to the inhibition reaction. This can partially explain the decrease in the rate of binase inhibition as compared with the corresponding reaction of barnase.

Bacterial Proteins↗
PubMedDate not supplied

[A possibility of significant lowering the defibrillation current by determining the right time for application of a defibrillating pulse. A mathematical model].

The effect of defibrillating pulses on the functionally determined re-entries (leading circles) was studied by computer simulation. Arrhythmias caused by different numbers of leading circles (from 1 to 18) were investigated. The defibrillation threshold was found to vary 2-4-fold, depending on the time of application of a pulse. At small currents the defibrillation mechanism is principally different from the commonly known one and is linked to the movement of leading circles towards each other or towards the boundary of the excitable tissue.

Arrhythmias, Cardiac↗
PubMedDate not supplied

[Interaction of spiral and flat periodic autowaves in an active medium].

Interaction between the rotating wave and a periodic external source in the model of Fitz Hugh--Nagumo type was computed. When the periods of the external source are longer than the rotation period of the spiral wave (T greater than Ts) the external source does not affect the spiral wave. At T less than Ts autowave synchronization effects are observed. The oscillation period predetermined by the external source is set in all the points of the medium except the neighbourhood of the spiral wave. The dislocation (wavebreak) persists in the medium drifting slowly at the angle to the wave vector of the flat waves. After the external source is eliminated, the spiral wave with the original period restores from this dislocation. When the dislocation reaches the interface, it disappears. In this case after the switching off of the external source the resting state is established. A theory of the drift is proposed which connects the drift velocity with the nucleus size and the rotation period of spiral wave.

Heart Rate↗
PubMedDate not supplied

[Characteristics of the action of non-narcotic analgesics in diabetics].

Patients with diabetes mellitus were examined for the action of non-narcotic analgesics during oral cavity sanitation. All the drugs under study (amidopyrine, pyranal, baralgin, probon) taken per os increased the threshold of tactile painful sensitivity and the threshold of pain endurance in patients with diabetes mellitus to a greater degree than in normal subjects. No such differences were recorded after diazepam intake under the same conditions.

Adolescent↗