A physico-mathematical model of human erythrocyte hypotonic hemolysis has been developed in this work. It quantitatively describes the kinetics of the phenomenon occurring when cells are suspended in a hypertonic aqueous solution of permeable non-electrolyte.

Cell Membrane Permeability↗

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[Dicarboxylic amino acids, GABA and serotonin in the hypothalamic area of rats of different ages].

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Age Factors↗

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[Hematologic complications during prolonged use of antidiabetic oral preparations].

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Diabetes Mellitus↗

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[Reaction of cells to hypertonic effects by cryoprotection].

Kinetics of volume changes in cells caused by hypertonic solutions has been investigated theoretically using an apparatus of the non-equilibrium thermodynamics. Analytical expressions for relaxation times of the two-stage process studied have been found. The reaction of mouse peritoneal exudate cells to hypertonic solutions of glycerol. PEO-400 or PEO-1500 has been studied experimentally. An agreement has been obtained between theoretical calculations and experimental results. Possible mechanism of cell injury caused by hypertony is discussed.

Animals↗

PubMedDate not supplied

[Ontogenic differences of glutamate decarboxylase, GABA-aminotransferase, monoamine oxidase activities of cerebral cortex mitochondria and hypothalamic cerebral area].

It is shown that the glutamate decarboxylase activity in the initial mitochondrial fraction of "light" and "heavy" synaptosomes of cerebral hemispheres changes on the 14th, 21st day, 1st, 3d, 12th and 24th months of rat development: in the hypothalamus area it lowers in the initial mitochondria in the 21-day animals, and in the fraction of "heavy" synaptosomes--in the 24 day animals as compared to the adult ones. The GABA-aminotransferase activity in the cortex synaptosome fraction rises in the period between the 14th and 21st day after birthday and in the initial mitochondrial fraction of the hypothalamus area--between the 14th day and the first month of life. In adult rats the glutamate decarboxylase and GABA-aminotransferase activities in the "heavy" synaptosome fraction are higher than in the "light" synaptosome one. The amine oxidase activity of the subcellular fractions which is determined with serotonin as a substrate (form A) is stable during the whole developmental period of studies. The intensity of benzylamine (amine oxidase B) desamination in the cortex fraction and hypothalamus area rises sharply in the second half of ontogenesis.

4-Aminobutyrate Transaminase↗