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Biomedical subjects

E A Grigor'eva

Publications and source records attributed to E A Grigor'eva.

At least 19 recordsLinked to original sources
PubMed2006

[Infiltrative pulmonary tuberculosis under the conditions of a large industrial center of Siberia].

Among the patients with infiltrative pulmonary tuberculosis, there was a rise in the proportion of patients aged 40 years or older, the unemployed, and individuals with aggravating social risk factors in the study period (2000-2001 and 1990). There was also an increase in the proportion of disseminated processes, cavity decay (2 cm or more in diameter), and massive bacterial isolation. The clinical manifestations of pulmonary tuberculosis were pronounced. Disseminated and destructive processes were more frequently detected among the patients having social risk factors, examined in the given period.

Adolescent↗
PubMed2002

[Composition and morphological characteristics of deaths from tuberculosis].

Two hundred and forty eighty deaths from pulmonary tuberculosis were analyzed in adults. The most frequent cause of deaths was progressive tuberculosis, mainly as caseous pneumonia (60.9%) and the less frequent one was a multicavernous process with bronchogenic (28%) and hematogenic (15%) dissemination. The high incidence of specific intrathoracic lymph nodal lesions, which has increased from 10.8% in 1994-1995 to 30.4% in 1997-1999, and a larger number of hematogenic dissemination from 6.7 to 25.6%, respectively, are noteworthy. Progressive tuberculosis was most commonly favoured by the patients' inadequate attitude towards their health: delayed visits to a doctor when they have symptoms of the disease, the absence of fluorographic examinations, treatment errors due to their incompliance.

Adult↗
PubMed2001

[Somatic diseases as cause of death of patients with active tuberculosis].

Two hundred and fifteen case histories were studied to clarify causes of death in patients with active tuberculosis who had died from it. Males accounted for the largest proportion (86%) (n = 185). Patients above 50 years were 63.3% (n = 136). Two thirds were patients with restrictive tuberculosis without destruction and bacterial isolation. A hundred and fifty (70%) and 30% patients died from somatic diseases and other causes (sequels to alcohol abuse, violent death, suicide, etc.), respectively. Of the somatic diseases, cardiovascular diseases head the list, cancer ranks next to it, nonspecific respiratory diseases occupy the third place.

Adult↗
PubMed1991

[The problems, mental disorders and quality of life of rheumatoid arthritis patients].

There were 157 patients with rheumatoid arthritis. Of these, only 65 patients (41.4%) failed to show any factor at the disease onset, which could be estimated as provoking. Psychoemotional factor was most common (in 47.7% of cases). Later the indicated factor played a more important part: only 5.1% of the patients denied or doubted it. In most cases, the distress was caused by family relations. There was an appreciable difference in the intensity of the problems in family and single patients. Affective disorders (neurotic and hypopsychotic depressions) were mostly recorded among mental disorders. The life quality determined in accordance with the self-estimation of the "health" and happiness" noticeably depended both on biological factors (pain intensity, the degree of damage to the bones and joints, and the disease stage) and on social factors--the educational level and social position. The degree of personality merits defined according to the self-estimation of the "mentality" and "character" appeared higher in persons with higher education and in patients suffering from erosive arthritis. The data obtained provide evidence for the necessity of psychosomatic orientation of practicing physicians.

Arthritis, Rheumatoid↗
PubMed1987

[Systems approach to prognostic criteria for depression].

In order to elucidate the prognostic criteria of depression in the structure of schizophrenia, manic-depressive psychosis, and psychogenias, the authors, using computer-based techniques, have identified groups of clinical symptoms of variable complexity (arbitrarily named as computerized syndromes) which determine the general outcome of the disease. Computerized syndromes of favourable and unfavourable prognosis with a high diagnostic accuracy can be used for individual prognosis.

Adult↗
PubMed1986

[Pharmacokinetics of digoxin in middle-aged and elderly patients in the subacute period of myocardial infarction].

Elderly and old patients with subacute myocardial infarction showed elevated gastrointestinal digoxin absorption rates and a tendency to increased bioavailability of the drug, as compared to similar parameters in infarction-free patients of the same age, so that blood digoxin peaks were higher in the former. The demonstrated absorption changes may be related to limited physical activity of the myocardial infarction patients examined. Digoxin pharmacokinetic patterns are analysed with reference to baseline myocardial contractility.

Administration, Oral↗
PubMed1984

[Systematic organization of the symptoms of depression].

Using a mathematical- locical techniques, a systemic organization of depressive symptoms at the level of components was suggested. This system may be used for evaluating the severity of the condition and determining its nosological character as well as for establishing prognostic criteria.

Affect↗
PubMed1984

[Effect of hemodialysis on digoxin pharmacokinetics in heart failure in patients with chronic kidney failure].

The authors have estimated the effect of hemodialysis on the pharmacokinetics of digoxin instilled intravenously to patients with the terminal stage of chronic renal insufficiency. It has been shown that dialysis was associated with an almost double increase in the clearance constant of digoxin due to its additional elimination through the membrane of the dialyzer. Over five h of dialysis the body excretes 12.5% of the administered dose of digoxin which is only 3.8% more (by 19 micrograms) than the average amount eliminated without dialysis. The contribution of dialysis to the elimination of digoxin is insignificant and, therefore, the regimen of its administration on days when dialysis is performed should be left unchanged.

Adult↗
PubMed1980

[Diagnosing depression of a neurotic and subpsychotic character].

Among 176 depressive symptoms informative symptomological combinations were differentiated (by means of mathematical methods) which characterize the neurotic and hypopsychotic depressions and provide a high percent of diagnosis of these conditions by a computer. An additional group of patients was distinguished which occupied a sort of intermediate position between the two mentioned categories. It was found, incidentally, that the vegetative syndromes within the framework of depressions have a rather small informative-diagnostic importance.

Adult↗
PubMed1980

[Bioavailability of digoxin tablets in cardiac insufficiency patients].

The bioaccessibility of Soviet produced digoxin tablets in elderly patients with cardiac insufficiency was studied. It is shown that in absolute bioaccessibility (62%) and other biopharmaceutic indices digoxin tablets made in the Soviet Union are equivalent to lanoxin tablets of the Burroughs Wellcome firm which are accepted by the USA FDA as the bioaccessibility standard. Equations fitted within a two-part mathematical model satisfactorily describe the changes in blood serum digoxin concentration in oral medication and in intravenous administration.

Aged↗
PubMed1979

[Severity of depression (clinico-statistical study)].

A total of 218 patients from 19-40 years of age with different depressions were examined. Four types of depressive disorders were distinguished: neurotic, hypopsychotic, psychotic, depressive-paranoid. It was demonstrated that depressive conditions of various severity possess differential symptoms with significantly different probabilities. Each clinical group had a certain set of differential symptoms, the amount and syndromal-diagnostical value of which was in a direct correlation with the affect severity. Signs of depression got complicated only to a certain limit. In depressive-paranoid syndrome there was a splitting of the depressive symptomatology: enhancement of some symptoms and alleviation of others.

Adult↗
PubMed1979

[Nosologic features of depression (clinico-statistical study)].

A clinico-statistical analysis of depressions with different nozological entities (125 cases) demonstrated that the nozological boundaries of endogenous and psychogenic depressions are quite obvious (if not considering the degree of the affect). Regarding the depth of affective disorders, the depressive symptomatology reflects mainly the general pathological regularities (the state of severity) and not so much the nozological traits of the disease.

Adjustment Disorders↗
PubMed1975

[Synthesis and characteristics of proteins in inner mitochondrial membranes of the myocardium of rats with disseminated necrotic heart diseases].

Two fractions of the inner membranes of the mitochondria were isolated from rat myocardium: complex-the inner membranes-matrix (fraction A); the aggregates of the inner membranes deproved of the matrix (fraction B). Both fractions of the membranes effectuated the incorporation of the radioactive amino acids with the same activity. With the aid of gel electrophoresis the amount of the protein components of A and B fractions was found to bary from 20 to 30. The mol wts were from 10000 to 200000. Disseminated myocardial necrosis produced by novodrine injection based on the ischemic state of the heart led in two days to a considerable decrease in the protein synthesizing activity of fractions A and B. The protein profiles and the mol wt of the membrane protein components displayed no marked changes.

Animals↗