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Biomedical subjects

E A Gromova

Publications and source records attributed to E A Gromova.

At least 19 recordsLinked to original sources
PubMed2006

[Sleep disturbances and a risk of myocardial infarction].

The aim of the study was to investigate the influence of sleep disturbances on the 8-year risk of myocardial infarction (MI) in men aged 25 to 64 years old. Screening of male inhabitants of one of Novosibirsk districts, aged 25 to 64 years, was performed within the framework of the WHO MONICA-psychosocial program in 1994. The cohort was followed up during 8 years (1994 - 2002) to determine end-points (MI). The statistical analysis was performed using SPSS- 10 software package. The relative risk (RR) of MI was evaluated using Cox proportional regressive model. Only one third of the 25 to 64-year-old male subjects with the first MI referred to their sleep as "good" whereas two thirds had sleep disturbances. The 8-year RR of MI in men aged 25 to 44 was 9.25 times higher in those whose sleep was estimated as '"poor" vs. those with "good" sleep, i. e. in this age group sleep disturbances were one of the most important MI risk factors; in 45 to 64 age group these differences were insignificant. RR of IM in men with sleep disturbances was higher in widowers, divorced men, men with low social support level, men with only primary education, working class men, and pensioners. The results demonstrate that sleep disturbances present a social problem and contribute greatly to the risk of MI in men of young age group.

Adult↗
PubMed2006

[Study of myocardial infarction risk factors within the framework of the WHO Monica-psychosocial program].

Three screening population studies were carried out within the framework of the WHO MONICA-psychosocial program in 1984, 1988, and 1994. The subjects of the study were male inhabitants of one of Novosibirsk districts aged 25 to 64 years. The cohort was studied during 18 years, from 1984 to 2002, using the WHO Acute Myocardial Infarction Register program. The statistical analysis was performed using SPSS-10 software package. The relative risk (RR) of myocardial infarction (MI) was estimated using Cox proportional regressive model. The greatest proportion (38.9%) of patients with MI was among men aged 45 to 54 years. Among men with MI, 58.7% had a high personal anxiety (PA) level. RR of MI was high among widowers, divorced and single men with a high PA level, in men with incomplete secondary or primary education, and men of hard or moderate physical labor. In the age group of 24 to 44, RR of MI during the first 5 and 10 years was 7.5 times higher in men with a high PA level vs. men with a medium PA level (p < 0.01). This explains the bigger number of men with MI in the group of 45 to 54 years of age.

Adult↗
PubMed2006

[Effects of hostility on the risk of arterial hypertension, myocardial infarction, stroke in a sample of males aged 25-64 years (epidemiological trial on the base of WHO program MONICA)].

AIM: To study effects of hostility on the risk of arterial hypertension (AH), myocardial infarction (MI) and stroke in males aged 25-64 years. MATERIALS AND METHODS: A screening study of the population was performed in 1994 according to WHO program MONICA-psychosocial. The response in a random representative sample of 25-64-year-old males (n = 657) living in Novosibirsk was 82.1%. New cases of MI, AH and stroke were registered in the control periods 1994-2000, 1994-2002. Computer program package SPSS-10 was used for statistic processing. Cox regression model of the relative risk (RR) was employed. RESULTS: Hostility was rather prevalent among the examinees (76.9%). MI risk for 8 years was 4.65 times higher in hostile men. Hostility was not associated with higher risk of AH and stroke. Hostility was seen more frequently in men with poor education, workers and retired persons. These groups are also at the highest risk of MI. CONCLUSION: Hostility raises MI risk in unstable society but had no effect on the risk of AH and stroke.

Adult↗
PubMed2005

[Study of the influence of vital exhaustion on myocardial infarction risk in a male population aged 25 to 64 years].

The aim of the study was to investigate the influence of vital exhaustion (VE) on the 8-year risk of myocardial infarction (MI) in men aged 25 to 64 years old. A random representative sample of male inhabitants of one of Novosibirsk districts, aged 25 to 64 years, was included in the WHO MONICA-psychosocial program. Within 8 years (1994-2000) all the cases of MI in the cohort were studied using the WHO Acute Myocardial Infarction Register project. The statistical analysis was performed using SPSS-10 software package. The relative risk (RR) of MI was evaluated using a Cox proportional regressive model. The prevalence of VE in subjects with MI was 65.8%. The 8-year RR of MI in men aged 25 to 64 years was 2.16 times higher (p < 0.05) in presence of VE and was the highest in widowers, divorced men, subjects with incomplete secondary or primary education, men of hard or moderate physical labor, and pensioners. The results show that RR of MYis associated with VE, which, in its turn, is directly related to social and economic status.

Adult↗
PubMed2005

[A study of the risk factors of stroke development in the framework of WHO program "MONICA-psychosocial"].

The study was conducted in the framework of WHO program "MONICA--psychosocial" in 1994-2002 using a randomized representative sample of males aged 25-64 years recruited from one district of Novosibirsk city. Over 8 years all stroke cases in the cohort have been registered and relative risk (RR) of stroke development was determined by special statistical methods. RR proved to be higher as follows: in males with depression--5,9-fold; with life exhaustion--3-fold; with low index of close relation--3-fold; with low index of social relations--4-fold; with sleep disturbance--2,7-fold; with stressful events in the family--2-fold; with stressful events at the job--4-fold. High level of hostility did not exert any influence on stroke development. Most frequently stroke occurred in men with higher negative psychosocial factors, i.e. widowers, divorced, those with primary and not-completed secondary school education and those engaged in hard and moderate manual labor as well as pensioners and individuals with low social support.

Adult↗
PubMed2005

[Risk of arterial hypertension and social support].

The aim of the study was to investigate the effect of social support on the 8-year risk of arterial hypertension (AH) in men aged 25 to 64. The researchers studied a random representative sample of male residents of a Novosibirsk district aged 25 to 64 years. The level of social support was evaluated by Berkman-Syme method. All the cases of AH which occurred in the cohort within 8 years (1994-2002) were investigated. The statistical analysis was performed using SPSS-11.5 software package. The relative risk (RR) of AH was evaluated using a Cox proportional regressive model. Within these 8 years the RR of AH was higher: 1) in men aged 25 to 64 years with low and medium close contact index (CCI) compared to men with high CCI (8.5 times); 2) in subjects with low social contact index (SCI) compared to subjects with high or medium SCI (4.8 times). In men aged 55 to 64 years the RR of AH was 15.9 times higher in men with low CCI. The highest rate of AH was found in men with low CCI and SCI belonging to the groups of widowers, divorced people, subjects with incomplete secondary or primary education, as well as in pensioners and people with low level of social support. The results show that AH risk in men aged 25 to 64 years is associated with low level of social support.

Adult↗
PubMed2005

[An 8-year study of depression effects on myocardial infarction risk in a population of 25-64 year old men].

AIM: To study depression effects on the risk of myocardial infarction (MI) for 8 years in men aged 25-64 years. MATERIAL AND METHODS: A random representative sample of men (n = 657) at the age between 25 and 64 living in Novosibirsk were screened in 1994 in the scope of WHO program "MONICA-psychosocial". The response was 82.1%. WHO "Register of Acute Myocardial Infarction" detected 58 cases of MI in the control period 1994-2002. Statistics were obtained with the program set SPSS-10. Cox regression model was used for estimation of a relative MI risk (RMIR). RESULTS: RMIR in 25-64-year-old men for 8 years was 2-fold higher in men with depression than without it, in the age group of 55-64-old men--5-fold. Depression was in 65.8% MI patients. The highest RMIR was in men with depression engaged in hard labour, retired, poorly educated, divorced, widowed. CONCLUSION: Risk of MI in men is related to depression due to social and economic status.

Adult↗
PubMed2004

[The WHO program "MONICA-psychosocial": risk of stroke and psychosocial factors (epidemiological study)].

An aim of the study was to investigate the influence of psychosocial factors on risk of stroke development during 16 years in men aged 25-64 years. Three scanning population surveys (1984, 1988, 1994) have been conducted in the frame of the WHO program "MONICA-psychosocial". Men at the age of 25-64 years, dwelling in a district of Novosibirsk city, were studied during a control period of 1984-2000. Statistical analysis was performed using SPPS-10 statistical package. Cox-proportional regression model was used for relative risk evaluation. The highest percentage of patients with stroke was found in the older group of 55-64 years. A distribution of personality anxiety level in men who survived stroke was as follows: 72.2% with high anxiety level and 27.8%-with a moderate one. The highest relative risk of stroke was observed in men with high anxiety, who related to the following groups: widowed and divorced; with primary and not-completed secondary school education; pensioners and those engaged in hard and moderate manual labor. The highest relative risk was during the first 5 years, being 6.8 times higher in subjects with higher anxiety level than in those with moderate level. For the following 10 years, relative risk was 5 times higher in men with high level of anxiety and after 16 years it was 3 times higher than in those with moderate anxiety level. The results obtained suggest that stroke most often develops at age of 55-64 years; its risk is associated with social gradient and is highest in the first 5 years. To prevent stroke, conditions reducing an impact of psychosocial factors on population are needed.

Adult↗
PubMed2001

Purification of recovered tellurium dioxide for re-use in iodine radioisotope production.

In the production of radioiodine via charged particle activation of isotopically enriched TeO2 and subsequent heating of the irradiated target, some TeO2 is lost. Again, use of recovered TeO2 for radioiodine production showed that impurities are present, which prevent complete volatilization of radioiodine from the heated target. An effective purification procedure for recovered TeO2 has been developed, resulting in a yield of 95-97%. The procedure developed may also be used to purify Te metal.

Journal Article↗
PubMed1992

[The exploratory behavior in an open field and in a burrowing chamber of rats with different predispositions to stress].

The peculiarities of oriental research behavior and correlation between activities of catecholaminergic and serotoninergic brain systems dependently on their stress resistance degree were investigated in Wistar rats. The experiments showed that resistant (R) to a sound stimulus rats differed from nonresistant (NR) ones by increased research activity under moderate stress in the open field test and by decreased research behavior level in the cell chamber test. The biochemical analysis of biogenic amines in different brain structures revealed increased norepinephrine levels in stress R rats, and increased dopamine and serotonin levels in NR ones. The findings suggest that inborn behavior regulation in animals with different stress resistance is determined by different correlations between serotonin-dopamine and norepinephrine brain systems activities.

Animals↗
PubMed1989

[Significance of the reciprocal relationship of monoaminergic systems of the brain in the pharmacological compensation of 6-hydroxydopamine-induced behavior disorders in animals].

The paper studied the methods of compensation of the abnormal emotional behaviour by means of pharmacological substances, which change the content of biogenic amines. The experiments made in the Wistar rats (n-54) whose frustration reaction was diminished by neonatal treatment of 6-OHDA. It was established that recovery of the disturbances in the frustration reaction in the animals with chronic brain system activity deprivation can be achieved not only by the activation of NA system (L-DOPA, DOPS) but also by deactivation of the 5-HT brain system activity (PCPA). These findings confirm suggestion about existence of reciprocal relationship between NA and 5-HT brain systems.

Animals↗
PubMed1989

[The role of the brain monoaminergic systems in the effects of tuftsin and its analog on animal emotional behavior].

The effects of tuftsin and its analogue TP-1 (300 micrograms/kg) on the animal adaptive behaviour in emotionally different situations, the level of biogenic amines and their metabolites 10, 30 min., 2 and 6 hrs after injection of these substances were studies. The TP-1 induced an increase in the memory traces stability better than tuftsin in emotionally negative situation. A single injection of the peptides induced changes in NA, DA and their metabolites contents for 30 min. to 2 hrs. In contrast to tuftsin, the TP-1 activated the metabolism of 5-HT in the hypothalamus and caudal brainstem without changing the NA turnover. The data obtained suggests that a stronger psychotropic activity of the TP-1 seems to be caused by its obvious effect on biogenic amines and their metabolites level in the brain.

Adaptation, Physiological↗
PubMed1989

[The role of the brain monoaminergic systems in the anti-alcohol action of dermorphin and the delta-sleep peptide].

The effects of dermorphin and DSIP were studied in male Wistar rats chronically treated with ethanol. Both peptides (200 mg/kg, i. p., daily during 10 days) significantly reduced volitional alcohol intake for 3-4 weeks. These effects were associated with a marked decrease in serotonin and its metabolite 5-HIAA levels in the hypothalamus. The findings suggest that antialcoholic effects of both peptides are actualized through mechanisms involving serotoninergic system of the brain.

Alcohol Deterrents↗
PubMed1988

[Effect of the active immunization of rats with a serotonin-protein conjugated antigen on the content of biogenic amines in the brain and on behavioral reactions].

Active immunization of rats with conjugated antigen serotonin-protein decreased the level of serotonin and its metabolite 5-hydroxyindole-3-acetic acid in some brain structures as well as the level of dopamine in the hypothalamus. The induction of antibodies to serotonin decreased the horizontal movement activity in the animals.

Animals↗
PubMed1988

[Characteristics of the action of psychostimulants on learning and memory in rats].

The effects of intraperitoneal injections of psychostimulant drugs: centrophenoxine (50 mg/kg) and peptide analog of tuftsin TP-1 (300 micrograms/kg) on the processes of elaboration and retention of conditioned reflex have been experimentally studied. The animals were trained with food reward in 30 trials per day. Psychostimulant drugs or saline were injected after the 10th trial. The elaboration of conditioned reflex was continued 30 min later. The retention was tested 24 h, 7 and 30 days later. It was established that both drugs induce an increase in memory traces stability during 30 days. These findings provide direct evidence that psychostimulant drugs, centrophenoxine and peptide substance TP-1, when injected during consolidation phase can enhance memory storage processes.

Animals↗