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Biomedical subjects

E A Konrad

Publications and source records attributed to E A Konrad.

At least 19 recordsLinked to original sources
PubMed1984

Schwannoma of the orbit.

Schwannoma of the orbit is an encapsulated, benign, noninvasive, slow-growing nerve sheath tumor which, when large enough, causes exophthalmos, optic neuropathy, diplopia, anterior orbital mass or sinusitis. An orbital schwannoma in a 84-year-old man with infiltration of the os spenoidale is reported. Schwannoma may arise anywhere within or adjacent to the orbit and is usually curable by local excision. The malignant counterpart, the malignant schwannoma, is exceedingly rare in the orbit. In orbital tumors many diagnostic steps are necessary, but the exact diagnosis is often determined only by histological examination. Schwannomas (synonyms neurilemoma, neurinoma) of the orbit are rare; they account for 1-6% of all orbital tumors. Here presented is a description of their appearance on clinical examination and on light and electron microscopy, together with a report on preoperative investigations and operative findings.

Aged↗
PubMed1983

Adenocarcinoma of the lacrimal gland with sebaceous differentiation. A clinical study using light and electronmicroscopy.

A case of metastasizing adenocarcinoma of the lacrimal gland with sebaceous differentiation is described, which probably originated in a benign mixed tumour (BMT), with infiltration of the orbital muscles, the bony orbital wall, the neck lymph nodes, and the parotid gland. The patient was a 69-year-old male with a proptosis that had persisted for 31 years. An orbital exenteration was performed. Death occurred due to cerebral tumour infiltration. In view of the sebaceous pattern meibomian gland carcinoma has to be ruled out in the differential diagnosis.

Adenocarcinoma↗
PubMed1983

Rhabdomyoma of the eyebrow region: a light- and electron microscopic study of a recurrent rhabdomyoma of fetal type.

A rhabdomyoma in the region of the right eyebrow in a 9-year-old boy is reported, which recurred 7 months after surgery. A local excision was performed, and the patient is free of disease 6 years later. Rhabdomyomas are exceedingly rare tumors. Hitherto only three unequivocal cases of orbital rhabdomyomas have been observed. A rhabdomyoma of the eyebrow region has to our knowledge not been described. Local excision is sufficient. In particular, a differential diagnosis of rhabdomyosarcoma has to be excluded.

Child↗
PubMed1983

Metatypical carcinoma of the lower eyelid.

Metatypical (syn. basosquamous) carcinoma, a variant of basal cell carcinoma, is morphologically and biologically different from the types usually encountered: although metatypical carcinoma is morphologically different from squamous cell carcinoma, it metastasizes with nearly the same frequency.

Carcinoma, Basosquamous↗
PubMed1982

Extracardiac rhabdomyoma: report of different types with light microscopic and ultrastructural studies.

Five extracardiac rhabdomyomas were studied by light and electron microscopy: two of the adult type, two of the fetal type, and one of the female genital tract type. The three types can be distinguished histologically and ultrastructurally. Adult type rhabdomyomas are encapsulated and reveal histologically closely packed, large tumor cells with granular or vacuolated cytoplasm and only scant stroma. Electron microscopically, myofibrils are haphazardly arranged with rodlike Z-band material. Sometimes a sarcomeric arrangement of myofibrils is seen. The tumor cells are packed with mitochondria bearing lamellar inclusions. Fetal type rhabdomyomas contain a mixture of muscle cells in different stages of differentiations; the amount of stroma is increased. The myofilaments are usually disorganized and in only a few cells is rodlike Z-band material found. The cytoplasm reveals few mitochondria. In the rhabdomyoma of the female genital tract, the tumor cells are large and resemble more mature muscle fibers; the stroma is abundant and the myofilaments are usually arranged in an orderly fashion. Generally, the prognosis for rhabdomyomas is good. Metastases are not known. Two of the five rhabdomyomas studied recurred. One rhabdomyoma was found at autopsy. Embryonal rhabdomyosarcoma must be considered in differential diagnosis particularly for fetal type rhabdomyoma.

Abdominal Neoplasms↗
PubMed1981

Extraskeletal Osteosarcoma. Case report and differential diagnosis.

In this case of an extraskeletal osteosarcoma initially there were typical difficulties in diagnosing a) a malignant mesenchymal tumor and b) a bone-producing tumor. Only focally the test-booking findings of an osteosarcoma were present. The differential diagnosis concerned mainly pseudosarcomatous lesions with bone formations, which histologically may appear suspicious, however, follow a benign course clinically.

Aged↗
PubMed1981

Chordoma with a predominant retrosacral tumor mass.

Chordomas are malignant tumors with lobulated structure which usually consists of vacuolated physaliferous cells in a mucoid stroma (Enzinger et al. 1969). These cells originate from remnants of the chorda dorsalis. Most chordomas are located either at the end of the vertebral column, i.e., in the sacrococcygeal region or at the base of the skull near the sphenooccipital synchondrosis. More than half of all tumors are located in the sacrococcygeal region. In contrast to most cases of sacrococcygeal chordomas which show a predominant presacral tumor infiltration we report on a patient suffering from a sacrococcygeal chordoma with a retrosacral tumor mass. Here, the presacral tumor infiltration became apparent only much latter. It was nevertheless of great prognostic relevance as tumor infiltration of the urinary bladder lead to lethal septicaemia.

Aged↗
PubMed1980

[Histological grading and typing in osteosarcoma. Comparison with the survival time of 22 patients].

Histological grading from I--III was carried out for 22 osteosarcomas. There was a positive correlation between higher histological grade of differentiation and higher rate of 2-years-survival. The death rate was 3,7 times higher for osteosarcomas of grade III than for grade I and II tumors. However, no significant differences as to prognosis and age of the patients, localization of tumor metastases, various stages and kind of therapy became evident. In spite of distinct regional differences, as subclassification according to 6 subtypes proposed by Scranton et al. (1975) was possible in all our cases. Statistically significant correlations between these subtypes of osteosarcoma and differences in survival time could not be found, neither for our own limited material, nor for the combined material, including the cases of Scranton et al.

Adolescent↗
PubMed1980

[Metastasized osteosarcoma with undifferentiated carcinoma-like parts].

This was the case of a 64-year-old man with osteosarcoma. The biopsy yielded undifferentiated tumor without bone or cartilage formation. Because of high age of the patient and radiological changes present, a metastatic carcinoma was suspected. However, no primary could be found. Autopsy revealed an osteosarcoma in the region of the hip joint with alternating formation of tumor cartilage and tumor bone. There were also undifferentiated portions of "endocrine osteosarcoma," simulating carcinoma. In spite of extensive skeletal involvement and pulmonary metastases--and high age--no evidence of morbus Paget of bone as possible preneoplastic disease was found.

Bone Neoplasms↗
PubMed1979

Fatal eosinophilic gastroenterocolitis in a two-year-old child.

We report a case of eosinophilic gastroenterocolitis in a 2-year-old child with extensive fibrosis, atrophy of the muscularis propria and involvement of stomach, small bowel and colon. Following an attack of acute gastroenteritis at the age of 15 months the symptoms of ileus persisted. A biopsy of small bowel at the age of 18 months showed numerous eosinophilic granulocytes in the mucosa. At the age of 28 months the child died with paralytic ileus. This is the first case known to us of an eosinophilic gastroenteritis in early childhood with a fatal outcome.

Colitis↗
PubMed1978

["Adamantinoma" of the tibia and reactive bone changes (author's transl)].

A case of "adamantinoma" of the tibia is reported. 10 years ago a giant tumor with fibrous dysplasia had been diagnosed in a biopsy taken from the same site of cystic bone changes. These findings may occur as reaction in the periphery of "adamantinomas" of long bones. By this experience the importance was emphasized, to obtain tissue from the center portion of the tumor to include the typical epithelial islets pathognomonic for "adamantinomas", which in our case, were found only 10 years after the first operation. Our patient was treated by curetting and filling of the defect with bony splinters. At this time, 8 months after surgery, he is without complaints and in full use of his diseased leg.

Ameloblastoma↗