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Biomedical subjects

E A Korneva

Publications and source records attributed to E A Korneva.

At least 19 recordsLinked to original sources
PubMed1992

The involvement of pineal gland and melatonin in immunity and aging: II. Thyrotropin-releasing hormone and melatonin forestall involution and promote reconstitution of the thymus in anterior hypothalamic area (AHA)-lesioned mice.

A stereotactic electrolytic lesion of the anterior hypothalamic area in mice produces a rapid involution of the thymus and a reduction of lymphocytes in the peripheral blood. This effect on the thymus and blood lymphoid compartment can be prevented by postoperational administration of thyrotropin-releasing hormone (TRH) or melatonin. These activities of TRH or melatonin are antagonized by the opioid receptor blocker naltrexone. They do not seem to depend on stimulation of the thyroid gland or of the endogenous opioid system but rather on a direct activity of TRH on thymic targets or binding sites on lymphocytes.

Aging↗
PubMed1992

[Monoamines in the hypothalamic structures in the first few hours after immunization].

This paper examines the time course of changes in the levels of dopamine, norepinephrine, serotonin and their metabolites in the hypothalamic structures closely related to neurohumoral regulation of immunogenesis. The findings suggest that the monoaminergic systems of the brain are widely involved in the body's response to antigen, which may lead to the conclusion that there are numerous modes of entering information from the immune to the nervous system.

Animals↗
PubMed1992

Altered interleukin-1 production in mice exposed to rotation stress.

This study examined the effects of rotation stress (78 circles per 1 min for 1 h: 10 min rotation + 5 min interval) on peritoneal macrophage release of lymphocyte-activating factors (LAF) and interleukin-1 alpha (IL-1 alpha) concentration in mice (CBA x C57BL6)F1. Rotation stress induced the macrophages' release of LAF with peak reactions in 0-1 h after termination of stress, followed by elevation of plasma IL-1 alpha. Induction of LAF release was accompanied by a higher concentration of corticosterone (Cs) in the blood, most prominent at 0 and 0.5 h after termination of the stressful procedure, and recovering to normal values 1 h later. It is suggested that the stimulating effect of stress on LAF and IL-1 production possibly involves glucocorticoid hormones, as well as other stress-induced neurohumoral shifts accompanying the reaction of glucocorticoids. It is also possible that the activated production of LAF and IL-1 by macrophages has a stress-limiting role in cases of mild stress.

Animals↗
PubMed1991

Fever produced by intrahypothalamic injection of interleukin-1 and interleukin-6.

Pure human interleukin-1 beta (IL-1 beta) and interleukin-6 (IL-6), both of natural origin, were found to cause fever in rabbits when injected into the PO/AH region of the brain. The threshold dose required for this effect was between 0.4 and 4 U, equivalent to 0.04 to 0.4 ng for IL-1 beta, and around 50 U, equivalent to 0.05 ng for IL-6. From this it was estimated that this area of the brain responds to a local concentration of approximately 1 ng/ml of these cytokines, a level which can easily be reached after intravenous administration of threshold pyrogenic doses of either cytokine. The observation supports the view that fever induced by systemic endogenous production of IL-1 and IL-6 is due to a direct effect on the thermoregulatory center and may not require production of mediators, such as prostaglandins, at sites distant from the center.

Animals↗
PubMed1991

[Nonspecific resistance of the body to transcranial electric stimulation in the analgesia regimen].

The authors studied the level of proteins in the acute phase of inflammation and the level of glucocorticoid hormones, the leukocyte composition, the functional activity of the peripheral blood phagocytes, and the body temperature in rabbits under normal conditions and in subcutaneous turpentine injection in transcranial electric stimulation in the analgesia regimen. Changes of the studied parameters and activation of the mechanisms of the organism's nonspecific resistance occurred on a model of aseptic inflammation. It is suggested that endogenous opioid peptides play a significant role in these changes.

Analgesia↗
PubMed1991

[The lymphocyte acetylcholinesterase activity in rats poisoned by pesticides].

The experiments carried out present the evidence of acetylcholinesterase activity of Wistar rat lymphocytes. It was shown that splenocytes and thymocytes had significantly different levels of the enzyme activity. Peroral administration of phosphor-organic pesticide antio (phormothion) 1/100 and 1/20 LD50 induced the dose-dependent inhibition of splenocyte acetylcholine-esterase activity after 2 months of treatment. It suggests the relation of the immunosuppressive action of pesticide with the interference into the neuromediator mechanisms regulating the lymphoid cell function.

Acetylcholinesterase↗
PubMed1989

Beginnings and main directions of psychoneuroimmunology.

The present paper offers a survey of advances in the domain of psychoneuroimmunology. Major topics covered are the role of the nervous system in regulation of the immune system functions, neuromediator and neuroendocrine mechanisms for regulation of the lymphoid cell activity and hypothalamic involvement in modulation of the activity of bone marrow as a source of stem cells. Emphasis has been on the neurophysiological correlates of the organism's reaction to antigen. Attention has been given to the work of A.D. Speransky and discussion of the psychoneuroimmunologic research based on literature data and findings from our own studies is presented in the historical context.

Animals↗
PubMed1989

[Immunohistochemical analysis of splenic tissue in rats with destruction of the hypothalamic structures].

The immunoenzyme histochemical technique to stain the IgM- and IgD-bearing cells was used to study the morphometric characteristics of B-lymphocyte-dependent zones in spleen white pulp of Wistar rats (intact, sham operated and after cortex or hypothalamic lesions). In the groups of sham-operated and cortex-lesioned rats it has been shown the increase of spleen weight 7 days after the operation due to the increase of the red pulp weight. The white pulp compartment's ratio is not affected. Lesioning of the posterior hypothalamic area prevents these effects of the operation, while local coagulation of the lateral hypothalamic area causes a significant decrease of the weight of spleen primary follicules which contain IgM+IgD+-bearing B-lymphocytes exerting characteristics of circulating pool of B-lymphocytes. These data are in favour of the CNS participation in regulation of B-lymphocyte migratory activity.

Animals↗
PubMed1988

Brain reactions to antigen.

The nervous and immune system receive and process information, can develop a specific response and possess memory properties. Here we report on electrophysiological responses of brain to antigen presentation. In particular, antigenic presentation to brain affects dynamic changes in the DC potential.

Animals↗
PubMed1988

[A model for exploring afferent signals from the immune system to the nervous system].

Mechanisms of information transmission from the immune system to the nervous system have been studied. The results of the studies support the assumption that these signals can be transmitted by oligopeptides (the products of limited proteolysis) which are the fragments found in the active sites of many regulatory peptides of the nervous and immune systems. The testing of a synthesized tripeptide (Ser-Lys-Asp) has shown that it inhibits the antibody-forming cells in intact mice only in response to the administration of large antigen doses and exerts a protective effect against viral infection. When added to the culture of the incubated leukocytes from the peripheral blood of the oncological patients, the tripeptide lowers an increased or normal functional activity of natural killers. In rabbits, tripeptide administration brings about a complex long-lasting reorganization of bioelectrical activity in subcortical structures of the brain.

Animals↗