Hyperlipoproteinemia corresponding to the IIb type was developed in the most patients with diffuse chronic glomerulonephritis and nephrotic syndrome. In blood concentration of very low density lipoproteins (VLDL) was increased with simultaneous accumulation of cholesterol in the fraction. Under conditions of nephrotic syndrome most distinct increase of the Sf 20-12 fraction and content of triglycerides, as compared with the Sf 12-0 fraction, was found in lipoproteins of low density (LDL) Content of cholesterol in high density lipoproteins (HDL) was decreased as compared with donor blood. Activity of postheparin lipoprotein lipase decreased in the most patients. Inspite of cholesterol accumulation in VLDL, triglycerides containing in the Sf 400-100 fraction of the patients were hydrolyzed by rat lipoprotein lipase at the high rate; hence, alteration of VLDL composition should be considered as a factor responsible for impairment of lipoprotein metabolism in blood. Content of VLDL was increased in blood of the patients within the first week of dexamethasone treatment. Within the subsequent period the hormone exhibited distinct hypolipidemic effect. In presence of the hormone heparin-dependent lipoprotein lipase was activated. Increase of lipolytic activity was observed in urine of patients simultaneously with distinct proteinuria.

Adolescent↗

PubMedDate not supplied

[Comparative evaluation of the treatment of radiation skin injuries with oxycort ointment and Peruvian balsam].

The regenerating action of Peruvian balm and oxycort was compared in experiments on rats with experimental radiation skin injuries. Radiation skin ulcers entailed severe morphological and biochemical abnormalities, there was also observed an unstable healing provided the treatment was not applied. Oxycort ointment slightly reduced the period of healing. However, formation of secondary microdefects was conducive to recurrent ulcer in the future. Peruvian balm exerted a pronounced bactericidal action, strongly intensified the reparative processes, and, therefore, reduced the period of healing and favoured the differentiation of the cicatricial tissues that led to a stable healing of the ulcers.

Administration, Topical↗

PubMedDate not supplied

[Clinical, radiologic and morphologic characteristics of localized forms of pulmonary tuberculosis. Tuberculosis and hypoplasia].

Clinical and x-ray examinations and study of operation material from 555 patients with local forms of tuberculosis permitted the authors to distinguish three form of the condition: tuberculoma (77% of cases), cavitary (cavernous) tuberculosis (16%), and tuberculosis of the bronchi (5%). Morphologic investigations showed the local tuberculosis develops at small sites of pulmonary tissue hypoplasia. Sites of hypoplasia are usually concentrated in the pulmonary segments which are formed in the postnatal period, thus explaining the typical localization of a postprimary tuberculous focus. Tissue decomposition with development of destruction cavities is not characteristic of local tuberculosis. Cavitary (cavernous) form is a morphologic reflection of a tuberculous inflammation in the zone of cestous hypoplasia. Morphonesis of local forms of tuberculosis reflects its social dependence.

Adult↗