Biomedical subjects
Publications and source records attributed to E A Lebedeva.
The combined craniocerebral trauma is accompanied by an impaired brain function in respect to regulating the entire organism and extends the neurohumoral processes of metabolism. The use of a bioregulator of the cytomedine class--epitalamin--is an actual trend in the treatment of the above pathology.
The effect of norepinephrine infusion at a constant rate (0.8 or 2.5 microg/kg/min), i.v.) on the diuiresis, sodium excretion with urine, glomerular filtration, and arterial pressure (AP) was studied in acute experiments on dogs. The sodium excretion was calculated as percentage relative to the filtration charge. Norepinephrine infusion at a constant rate of 0.8 microg/kg/min led to an increase in the urine volume, in the amount of excreted sodium with increased AP (pressor diuresis effect), and glomerular filtration with increasing AP, while the level of reabsorption remained unchanged. An increase in the infusion rate to 2.5 microg/kg/min, led to a decrease in the urine volume, the level of sodium excretion, and the rate of glomerular filtration. In this case, the AP level was higher than that in the first series of experiments, and the level of sodium reabsorption was increased.
The purpose of the work was to study correlation between blood Se levels and lipid fractions in patients with severe type I diabetes mellitus. Great individual variations of Se blood concentrations were noted in diabetic patients. There was no statistically significant difference from Se levels in healthy persons. Positive correlation of Se levels with the atherogenic factors and negative correlation with antiatherogenic factors were noted in the control group.
White non-inbred rats received rations with varying content of the test fish product. Animals given the ration with casein served as controls. The changes in the animals' body mass, the relative mass of the internal organs, as well as their morphology and parameters of protein and lipid metabolism were studied. The analysis of the results obtained has shown that the fish product investigated in the amounts comprising 1.8 and 4.5% of the total calorific value of the ration produces no changes in the animal's body.
Anaprilin pharmacodynamics was studied in thyrotoxicosis patients. The clinical therapeutic effect of anaprilin, mercazolyl and their combinations was studied. In anaprilin therapy the drug should be individually dosed out with regard to its basal concentration in the blood and the degree of pulse retardation at rest. An adequate anaprilin dose for most patients was 160 mg/day. Anaprilin-mercazolyl combined therapy resulted in more retarded pulse as compared to a single drug therapy with anaprilin. The effect of anaprilin was potentiated by mercazolyl doses which did not by themselves cause a positive cardiovascular effect in the first two weeks of therapy.
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The influences of the contrast-unloading week (CUW) on the changes in the anthropometric and lipid metabolism parameters was studied in 150 female patients with metabolic alimentary obesity of the II-III stages, aged from 20 to 40. On the basis of the analysis of the changes in lipid metabolism in relation to their initial level and the hyperlipoproteinemia type it is suggested that the developed CUW is mostly indicated in a combined therapy of patients with the IV type of hyperlipoproteinemia. In the II type it is recommended in combination with a dosaged physical loading. CUW can be used in out-patients, which is confirmed by the experience in the prophylactic examination of patients with metabolic alimentary obesity.
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The paper concerns the determination in rabbit experiments of tetracycline antibiotics in meat products and in half-finished meat products. Discusses the degree of chlortetracycline inactivation in meat products exposed to thermal treatment. Residual amounts of antibiotics detected both in meat samples and in half-finished products as well as the effect of thermal treatment on antibiotic inactivation in relation to their content in the products require that strict control should be exercised over the use of antibiotics in animal breeding.
Over a month a group of 65 practically healthy medical students, leading a usual life, received diets according to the apportionment elaborated in agreement with "Recommended Values of Food and Energy Physiological Requirements" (1968). From daily measurement of body weight it was established that normally the weight got stabilized after two weeks' elapse from the commencement of observation. The caloric value of the food taken was assessed in 16 subjects under test. The daily caloric value of the food amounted on the average to 2980.10 +/- 88.18 kcal. i.e. it was 10% less as compared to the recommended energy requirement rates of male students. From previously reported data on protein metabolism and parameters of working capacity recorded in the same persons under observation it is concluded that the caloric value of the food taken equal to 2980.10 +/- 88.18 kcal is quite enough to replace energy losses of the students.
A hypothesis is advanced, according to which substances containing an amino group can compete with glucose in binding with protein groups and inhibiting in this way glycosylation. Screening in vitro experiments with nicotinic acid, nicotinamide, piracetam, panangin, ascorbic acid, bucarban, betanase, and adebit in a concentration of 10(-3) M were performed. Bucarban, betanase, and adebit were found to be capable of inhibiting glycosylation. Daily oral administration of bucarban and adebit in therapeutic doses for one month reduced the blood fructosamine level in rats with alloxan diabetes without changing the level of glycemia.